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Name : ureC (YE0953) Accession : YP_001005287.1 Strain : Yersinia enterocolitica 8081 Genome accession: NC_008800 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : 3.5.1.5 Position : 1076597 - 1078315 bp Length : 1719 bp Strand : + Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC DNA sequence : ATGCCTCAAATTTCTCGGCAAGAATACGCGGGTCTATTTGGCCCAACGACTGGCGATAAAATCCGTTTGGGTGACACCAA TCTATTTATCGAAATCGAAAAAGACCTGCGTGGATATGGTGAAGAGTCGGTTTACGGTGGGGGCAAGTCATTGCGTGACG GGATGGGCGCGAATAACCATCTGACCCGCGATAACGGTGTACTGGATTTAGTCATAACCAACGTCACTATTGTTGATGCT CGTTTAGGGGTTATCAAAGCCGACGTCGGTATCCGTGATGGTAAAATTGCCGGTATCGGTAAAAGTGGTAACCCTGGGGT GATGGATGGTGTCACTCCCGGCATGGTGGTAGGCGTTAGCACCGATGCTATTTCCGGTGAACATTTGATTCTCACTGCCG CCGGTATTGATAGCCACATTCACTTAATCTCCCCACAACAGGCTTACCATGCGCTCTCTAATGGCGTGGCAACCTTCTTC GGTGGCGGGATTGGCCCAACCGATGGCACTAACGGAACCACCGTTACCCCTGGCCCTTGGAATATTCGCCAGATGCTGCG CTCAGTTGAAGGGCTGCCGGTCAACGTGGGTATTCTGGGTAAAGGTAACTCTTACGGCCGTGGCCCGCTGTTGGAACAGG CGATTGCCGGTGTTGTCGGCTATAAAGTCCACGAAGACTGGGGCGCGACAGCCAATGCCCTGCGCCATTCATTACGGATG GCGGATGAAATGGATATTCAGGTTTCCGTACATACCGACAGTTTGAACGAATGTGGTTATGTAGAAGACACCATTGATGC CTTCGAAGGCCGCACCATCCACACTTTCCACACCGAGGGGGCGGGCGGGGGGCATGCGCCGGATATCATCCGTGTTGCCA GTCAGCCTAACGTACTACCAAGTTCGACTAACCCAACCCTGCCATACGGGGTGAACAGCCAAGCCGAACTGTTCGACATG ATCATGGTGTGTCATAACCTCAACCCGAATGTACCTGCTGACGTCTCCTTTGCTGAAAGCCGTGTGCGCCCGGAAACCAT CGCGGCAGAAAACGTTCTGCACGATATGGGGGTTATCTCCATGTTCTCCAGTGACTCACAAGCCATGGGGCGTGTGGGGG AAAACTGGCTACGTGTGATGCAAACGGCTAACGCAATGAAAGCATCACGCGGCAAATTGCCAGAAGATGCGCCGGGTAAC GATAACTTCCGCGTCCTGCGCTATGTGGCAAAAATCACCATTAACCCAGCGATTGCACAAGGTGTCAGCCATGTCATCGG TTCAGTTGAAGTGGGCAAAATGGCCGATCTGGTGCTGTGGGATCCGCGTTTCTTTGGTGCGAAACCTAAGATGGTTATCA AAGGCGGCATGATCAACTGGGCGGCAATGGGTGATCCGAACGCCTCATTACCAACCCCACAACCGGTGTTCTATCGTCCA ATGTTTGGCGCAATGGGTAAAACCATGCAAGACACCTGCGTCACCTTCGTTTCTCAGGCCGCGCTGGATGATGGCGTGAA AGAGAAAGCCGGGCTGGATCGCCAGGTTATTGCGGTTAAAAACTGCCGTACCATCTCTAAACATGACTTGGTGCGTAATG ACCAAACACCAAACATTGAAGTGGATCCTGAAACCTTTGCGGTGAAAGTGGATGGCGTACATGCCACCTGTGAACCTATA GATACAGCAGCAATGAACCAGCGCTATTTCTTTGGTTGA Protein sequence : MPQISRQEYAGLFGPTTGDKIRLGDTNLFIEIEKDLRGYGEESVYGGGKSLRDGMGANNHLTRDNGVLDLVITNVTIVDA RLGVIKADVGIRDGKIAGIGKSGNPGVMDGVTPGMVVGVSTDAISGEHLILTAAGIDSHIHLISPQQAYHALSNGVATFF GGGIGPTDGTNGTTVTPGPWNIRQMLRSVEGLPVNVGILGKGNSYGRGPLLEQAIAGVVGYKVHEDWGATANALRHSLRM ADEMDIQVSVHTDSLNECGYVEDTIDAFEGRTIHTFHTEGAGGGHAPDIIRVASQPNVLPSSTNPTLPYGVNSQAELFDM IMVCHNLNPNVPADVSFAESRVRPETIAAENVLHDMGVISMFSSDSQAMGRVGENWLRVMQTANAMKASRGKLPEDAPGN DNFRVLRYVAKITINPAIAQGVSHVIGSVEVGKMADLVLWDPRFFGAKPKMVIKGGMINWAAMGDPNASLPTPQPVFYRP MFGAMGKTMQDTCVTFVSQAALDDGVKEKAGLDRQVIAVKNCRTISKHDLVRNDQTPNIEVDPETFAVKVDGVHATCEPI DTAAMNQRYFFG |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 2e-153 | 58 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 2e-153 | 58 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 5e-141 | 57 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-141 | 57 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-141 | 57 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 3e-141 | 57 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_001005287.1 | urease subunit alpha | VFG0270 | Protein | 3e-147 | 58 |
