Gene Information

Name : guaA (YE1082)
Accession : YP_001005414.1
Strain : Yersinia enterocolitica 8081
Genome accession: NC_008800
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1211788 - 1213365 bp
Length : 1578 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACAAAAAATATCCATAAACATCGCATTCTTATCCTCGATTTCGGTTCGCAATACACCCAACTGGTGGCGCGCCGTGT
TCGTGAAATTGGTGTCTATTGCGAACTTTGGGCGTGGGATGTGACCGAAGACCAGATCCGCGAATTTAATCCAAGCGGCA
TCATTCTCTCCGGCGGCCCTGAAAGCACCACTGAACATGACAGCCCACGTGCGCCTGATTATGTGTTCACTGCTGGGGTT
CCGGTGCTGGGTGTGTGCTATGGCATGCAAACCATGGCAATGCAGCTGGGCGGTAAAGTAGAAGGGTCAAACCAACGTGA
ATTCGGTTATGCGCAGGTTGAAATTAAAACTGACAGCGCGCTTATCCGTGATATCAAAGATGCCATCAATCCAGCCGGTG
AAGCGGTGTTGGATGTTTGGATGAGTCATGGCGACAAGGTTACCGCGATCCCGTCTGACTTTGTCACCGTAGCCAGTACT
GATACCTGCCCGTTTGCCATTATGGCTAACGAAGAAAAACGTTTTTATGGCGTGCAGTTCCACCCTGAAGTGACGCACAC
CAAGCAAGGTCAACGCCTGCTGGAGCGCTTTGTTCTGGATATCTGTGCTTGTGAAGCACTGTGGACCCCGGCCACCATTA
TTGAAGATGCTATCGTGCGTTTGCGTGAGCAAATTGGTGAAGACCACGTCATTCTTGGTCTGTCCGGTGGTGTTGACTCA
TCCGTGACCGCAATGCTGTTGCATCGTGCTATTGGTAAACGTCTGACTTGTGTGTTTGTTGATAACGGCCTGCTGCGTTT
GAATGAAGCGGATCAGGTGTTGGAAATGTTCGGCGATAAATTCGGCCTGAACATTGTTCATGTGGCGGCAGAAGATCGTT
TCCTGGCGGCACTGGCTGGTGTTGATGAACCAGAAGCCAAGCGTAAAATCATTGGTCGCGTGTTTGTTGAGTTATTTGAC
GAAGAAGCCTGTAAACAAGAACAGGTTAAATGGCTGGCGCAGGGCACTATCTACCCAGACGTGATTGAATCCGCTGCATC
TGCCACCGGTAAAGCGCATGTGATTAAATCGCATCACAATGTGGGCGGCTTGCCTAAAGAGATGAAACTGGGCTTGGTTG
AACCGCTGAAAGAGCTGTTTAAAGACGAAGTGCGTAAAATCGGCCTCGAACTTGGCCTGCCATACGACATGCTATATCGT
CATCCATTCCCAGGCCCAGGTTTGGGTGTGCGCGTTCTCGGCGAAGTGAAAAAGGAATATTGTGATTTACTGCGCCGCGC
GGATGCTATCTTTATCGAAGAGCTGCATAAAGCAGATCTGTACAATAAAGTCAGCCAGGCCTTTACCGTGTTCCTGCCAG
TTCGTTCCGTCGGTGTGATGGGCGATGGTCGTAAATATGACTGGGTTGTCTCTCTGCGTGCGGTTGAAACTATTGATTTC
ATGACAGCACATTGGGCGCATTTGCCATATGACTTCCTGGGTCGTGTTTCAAACCGCATCATTAATGAAGTCAATGGTAT
TTCCCGAGTAGTTTACGATATTAGTGGTAAACCACCTGCAACAATTGAGTGGGAATAA

Protein sequence :
MTKNIHKHRILILDFGSQYTQLVARRVREIGVYCELWAWDVTEDQIREFNPSGIILSGGPESTTEHDSPRAPDYVFTAGV
PVLGVCYGMQTMAMQLGGKVEGSNQREFGYAQVEIKTDSALIRDIKDAINPAGEAVLDVWMSHGDKVTAIPSDFVTVAST
DTCPFAIMANEEKRFYGVQFHPEVTHTKQGQRLLERFVLDICACEALWTPATIIEDAIVRLREQIGEDHVILGLSGGVDS
SVTAMLLHRAIGKRLTCVFVDNGLLRLNEADQVLEMFGDKFGLNIVHVAAEDRFLAALAGVDEPEAKRKIIGRVFVELFD
EEACKQEQVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKLGLVEPLKELFKDEVRKIGLELGLPYDMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
MTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 7e-127 50
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 5e-127 50
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 5e-127 50
guaA NP_938969.1 GMP synthase Not tested Not named Protein 4e-111 47