Gene Information

Name : guaA (CJJ81176_1264)
Accession : YP_001000924.1
Strain : Campylobacter jejuni 81-176
Genome accession: NC_008787
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1178122 - 1179657 bp
Length : 1536 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGAAAAAAGCAGATATTTTAGTTTTAGACTTTGGTTCTCAATACACTCAGCTTATAGCAAGACGCTTAAGGGAACAAGG
AGTTTATGCAGAAATTTTACCTTTTAATGTAAGCTTAGCTGATATTAAGGCGAAAGAACCAAAAGGTATTATTTTAAGCG
GAGGTCCAGCAAGCGTATATGCAACTGATGCGTATTTTTGCGATAAAGGCATATTTGACTTGGGTTTACCTGTTCTTGGA
ATTTGTTACGGTATGCAGCTTATGGCACATCATTACAAAGCCACAGTTGCACCTGCAGGACATAAAGAATACGGTAAAGC
AAATATAGAGATCAAAAAAGACAGTGCTTTATTTAAAAATCTTCCAAAAAAGCAAACCGTTTGGATGAGTCATTCTGATA
AAGTAGAAAATTTACCTGATGGTTTTGAAGTTTTAGCCACAAGTGAAAATAGCCCTTTTTGTGTTTTTGGCAACGAAGAT
AAGAAATTTTTTGCCTTACAATTTCACCCAGAAGTACAACACAGTGAATTTGGCAAAAATATCTTAAAAAATTTTGCTAA
ATACGCTTGTAATTGCGAAAGTGTTTGGAATATGGGCTCTTTTGCAAAAACTCAAGCAGAAAAAATCCGTGAAGAAGTAG
GCAATGATAAAGTGCTTTGTGCAGTAAGTGGCGGAGTAGATAGTAGCGTAGTTGCTGCACTTTTAGCTAGTGCTATAAAA
GAACAAGTTATAGTAGTTTTTGTAGATAATGGACTTTTAAGAAGTGGAGAAAAAGAACAAGTTGAATTTATGTTTAAAAA
TACCTTAGGTATCGATCTTATCAGCATTGATGCAAGTGAAATTTTCCTAAGTCGCTTGGCTAATGTTAGAGATCCTGAGC
AAAAAAGAAAAATCATAGGAAATACCTTTATAGAAGTTTTTGAAGAAGAAGCAAAAAAACATAAAGATGTAAAATATCTC
GCTCAAGGCACACTTTATACTGATATCATAGAAAGTTCTGTTGTAGGTGCAAGCAAAACCATTAAAAGCCATCATAATGT
AGGGGGCTTACCTGAAAAAATGAATCTTAAACTCATAGAGCCTTTAAAAGAAATTTTTAAAGATGAAGTGCGTGCCTTAG
GACTTGAGCTTGGACTTAGCAAAGAAGTAGTTTATCGTCATCCTTTCCCTGGGCCAGGGCTTGCTATACGCATTATGGGA
GAAGTAAATCGCCCTAGCTTAGAACTATTACGCAAGGTTGATGTAATTTTACTCGAAGAACTTAAAAGTACAGGTTGGTA
TGATAAAACTTGGCAAGCATTTTGCGTGCTTTTAAATGTTAAAAGCGTTGGGGTTATGGGGGATAACCGCACTTATGATA
ATGCAGTTTGCATACGTGTTGTAGATGCAAGTGATGGTATGACAGCTACTTTCTCGCATTTACCTTACGAAGTTTTAGAA
AACATAAGTCGCCGTATCATCAATGAAGTAGAAGGTATAAATCGCGTTGTTTATGATATCTCAAGCAAACCACCTGCAAC
CATAGAATGGGAATAA

Protein sequence :
MKKADILVLDFGSQYTQLIARRLREQGVYAEILPFNVSLADIKAKEPKGIILSGGPASVYATDAYFCDKGIFDLGLPVLG
ICYGMQLMAHHYKATVAPAGHKEYGKANIEIKKDSALFKNLPKKQTVWMSHSDKVENLPDGFEVLATSENSPFCVFGNED
KKFFALQFHPEVQHSEFGKNILKNFAKYACNCESVWNMGSFAKTQAEKIREEVGNDKVLCAVSGGVDSSVVAALLASAIK
EQVIVVFVDNGLLRSGEKEQVEFMFKNTLGIDLISIDASEIFLSRLANVRDPEQKRKIIGNTFIEVFEEEAKKHKDVKYL
AQGTLYTDIIESSVVGASKTIKSHHNVGGLPEKMNLKLIEPLKEIFKDEVRALGLELGLSKEVVYRHPFPGPGLAIRIMG
EVNRPSLELLRKVDVILLEELKSTGWYDKTWQAFCVLLNVKSVGVMGDNRTYDNAVCIRVVDASDGMTATFSHLPYEVLE
NISRRIINEVEGINRVVYDISSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 9e-136 55
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-135 55
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-135 55
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-116 48