Gene Information

Name : guaA (Veis_1245)
Accession : YP_996031.1
Strain : Verminephrobacter eiseniae EF01-2
Genome accession: NC_008786
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1381683 - 1383302 bp
Length : 1620 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGCAACACCAGAAAATCCTGATCCTCGACTTCGGCTCACAGCTCACCCAACTCATCGCCCGCCGCGTGCGCGAGGCCCA
TGTGTACTGCGAGGTGCAGCCCTGCGACGTGAGCGACGAGTGGCTGCGTGCGTATGCCCAAGACGGCTCGCTCAAGGGCG
TGATCCTGTCCGGCAGCCACGCCAGCGTGTATGAAGACAGCACCGACAAGGCGCCCCAGGCGGTGTTCGCGCTGGGCCTG
CCAGTGCTGGGCATCTGCTACGGCATGCAAACCATGGCGCATCAGCTCGGCGGCAAGGTCGAGAGCGGCCGACAGCGCGA
ATTCGGCATGGCCGCCGTGCGCGCACGCGGCCACACCGCGCTGCTGGCCGACATTGCCGACTTCACCTCCCCCGAAGGCC
ACGGCATGCTCGAGGTGTGGATGAGCCACGGCGACAAAGTCACCGAGTTGCCCCCGGGCTTTACGCTCATGGCCAGCACC
GACAGTTGCCCGATTGCCGGCATGGCCGACGAGAAACGGCGCTTTTATGCCGTGCAGTTCCACCCCGAAGTCACGCACAC
GGTGCAGGGCCGGGCGCTGCTGGAGCGCTTTGTGCTGGGCATCTGTGGCGCCAGGCCCGACTGGGTGATGCGCGACCACA
TTGCCGAGGCGCTGGTGCAGATCCGCCAGCAGGTCGGCGTCGAGCAGGTGATCCTGGGCCTTTCGGGCGGCGTGGACTCC
TCCGTGGCCGCAGCGCTGATACAGCGCGCCATCGGCGCGCAACTCACCTGCGTGTTCGTCGATCACGGCCTGCTGCGCCT
GAACGAAGGCGACATGGTCATGGACATGTTCGCAGGCCGGCTGCAAGCCCGGGTGATCCGGGTCGACGCCAGCGAGTCAT
TCCTGTCCCGGCTGGCGGGCGTGAGCGACCCGGAAGCCAAGCGCAAGATCATCGGTGGCCTGTTCATCGAGGTATTCAAG
ACCGAGGCCGCCAAGCTCAAAGCCAACAACGCCGAGCACCGGGGCGCCACTTTCCTCGCACAGGGCACCATCTATCCCGA
CGTGATCGAATCGGGCGGCGCCAAGAGCAAAAAGGCCGTCACCATCAAGAGCCACCACAACGTCGGTGGCCTGCCCGAGC
AACTGGGCCTGAAACTGCTGGAACCATTGCGCGACCTGTTCAAGGACGAAGTGCGCGAGTTGGGCCTGGCCCTGGGCCTG
CCGCCCGAGATGGTCTACCGCCACCCATTCCCCGGCCCCGGCTTGGGCGTGCGCATCCTGGGCGAGGTGAAGAAGGAATT
CGCCGACCTGCTGCGCCAAGCCGACGCGATCTTCATCGAAGAACTGCACAACTTCACCGACCCCGCCACAGGCAAGACTT
GGTACCAACTGACCAGCCAGGCCTTCGCCGTGTTCCTGCCGGTCAAGAGCGTGGGCGTGATGGGCGACGGCCGCACCTAC
GACTACGTTGTGGCGCTGCGCGCCGTGCAGACCAGCGACTTCATGACAGCCGACCAGGCCGAACTGCCCTACGCCCTGCT
CAAGAAAGTGTCGAGCCGCATCATCAACGAAGTGCGTGGCATCAACCGCGTGACCTACGACATATCGAGCAAGCCACCGG
CGACCATCGAGTGGGAATGA

Protein sequence :
MQHQKILILDFGSQLTQLIARRVREAHVYCEVQPCDVSDEWLRAYAQDGSLKGVILSGSHASVYEDSTDKAPQAVFALGL
PVLGICYGMQTMAHQLGGKVESGRQREFGMAAVRARGHTALLADIADFTSPEGHGMLEVWMSHGDKVTELPPGFTLMAST
DSCPIAGMADEKRRFYAVQFHPEVTHTVQGRALLERFVLGICGARPDWVMRDHIAEALVQIRQQVGVEQVILGLSGGVDS
SVAAALIQRAIGAQLTCVFVDHGLLRLNEGDMVMDMFAGRLQARVIRVDASESFLSRLAGVSDPEAKRKIIGGLFIEVFK
TEAAKLKANNAEHRGATFLAQGTIYPDVIESGGAKSKKAVTIKSHHNVGGLPEQLGLKLLEPLRDLFKDEVRELGLALGL
PPEMVYRHPFPGPGLGVRILGEVKKEFADLLRQADAIFIEELHNFTDPATGKTWYQLTSQAFAVFLPVKSVGVMGDGRTY
DYVVALRAVQTSDFMTADQAELPYALLKKVSSRIINEVRGINRVTYDISSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 9e-124 50
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-123 50
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-123 50
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-111 48