Gene Information

Name : hemC (NMC0478)
Accession : YP_974579.1
Strain : Neisseria meningitidis FAM18
Genome accession: NC_008767
Putative virulence/resistance : Unknown
Product : porphobilinogen deaminase
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0181
EC number : 2.5.1.61
Position : 501109 - 502044 bp
Length : 936 bp
Strand : +
Note : transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis

DNA sequence :
ATGAACCCGAAAAAACTCGTCATCGCCAGCCGCGAAAGCCTGCTTGCTATGTGGCAGGCAAAGCATATCCAAGGCCGTCT
GAAGGCTCTGTATCCCGATTGCGAAGTCGAGATTTTGGGCATGACCACGCGCGGCGATCAGATTTTGGACAAAACTTTGT
CAAAAGTCGGCGGTAAAGGCTTGTTTGTCAAAGAGTTGGAACAGGCTTTATATGACGGGCGCGCCGATTTGGCGGTGCAT
TCGATTAAGGACGTGCCGATGGATTTGCCTGAAGGTTTCGCGCTTGCCGCCATCGGCGAACGCGCCAATCCGTTTGACGC
GTTTGTGTCCAACCAATACGCGCGTTTGGAAGAAATGCCCAAAGGCGCTGTCGTCGGTACATCCAGCCTGCGCCGCGAAG
CCCAGTTGCGCGCGCGCTATCCGCATTTGCTTATCAAACCTTTGCGCGGCAATGTGCAAACCCGTTTGTCCAAACTCGAT
AACGGCGAATACGACGCAATTATTTTGGCCGCCGCCGGTTTGCAGCGTCTGAAATTGGACGGACGCATCCGCATGATTTT
GTCGGAATCCGACAGCCTGCCTGCCGCCGGACAAGGCGCATTGGGTATCGAAATTGCCGCGCACCGCGAAGATTTGTATG
AGGTTTTAAAACCGCTAAACCACGATACCACACACGCCTGCGTTACGGCCGAACGAGCTTTGGCGCGCGCTTTGGGCGGA
AGCTGCCAAGTGCCGCTGGCCGCATATTGCACGGAAGAAAACGGCTTGCTGACCTTGCGCGGACTGGTCGGACACCCCGA
CGGTTCGGTTGTGTTGCAGGCGGACGCGCAAGCCCCTGCCGAATATGCCGACGCGCTCGGACGCGCTGTCGCTAAGAAAT
TGGCGGACGACGGTGCGCGGGAATTGATTGGAGCAGTATTGAATACGGAAAATTGA

Protein sequence :
MNPKKLVIASRESLLAMWQAKHIQGRLKALYPDCEVEILGMTTRGDQILDKTLSKVGGKGLFVKELEQALYDGRADLAVH
SIKDVPMDLPEGFALAAIGERANPFDAFVSNQYARLEEMPKGAVVGTSSLRREAQLRARYPHLLIKPLRGNVQTRLSKLD
NGEYDAIILAAAGLQRLKLDGRIRMILSESDSLPAAGQGALGIEIAAHREDLYEVLKPLNHDTTHACVTAERALARALGG
SCQVPLAAYCTEENGLLTLRGLVGHPDGSVVLQADAQAPAEYADALGRAVAKKLADDGARELIGAVLNTEN

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00327 YP_008207792.1 Porphobilinogen deaminase Not tested AbaR25 Protein 4e-69 56
BJAB0868_00331 YP_008211657.1 Porphobilinogen deaminase Not tested AbaR26 Protein 4e-69 56