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Name : leuS (NMC0326) Accession : YP_974439.1 Strain : Neisseria meningitidis FAM18 Genome accession: NC_008767 Putative virulence/resistance : Unknown Product : leucyl-tRNA synthetase Function : - COG functional category : J : Translation, ribosomal structure and biogenesis COG ID : COG0495 EC number : 6.1.1.4 Position : 327943 - 330573 bp Length : 2631 bp Strand : + Note : leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl DNA sequence : ATGCAAGAACATTACCAACCCGCCGCCATCGAGCCTGCGGCGCAGAAAAAATGGGACGACGCCCGTATTTTCAACGTCTC CGAAGACGCTTCCAAACCCAAATATTATTGCCTCTCCATGTTCCCCTATCCCAGCGGCAAGCTGCACATGGGGCATGTGC GCAACTACACCATCGGCGATGTATTGAGCCGCTTCAAACTTTTAAACGGCTTCAACGTCATGCAGCCTATGGGTTGGGAC GCGTTCGGCATGCCGGCGGAAAACGCGGCGATGAAAAACAACGTCGCCCCTGCCGCTTGGACGTACGATAACATCGAATA CATGAAAACCCAGCTCAAAAGCCTGGGTTTTGCGATTGACTGGGCGCGCGAAACCGCAACCTGCAAACCCGAATACTACC GCTGGGAACAATGGCTGTTTACCAAGCTGTTTGAAAAAGGCATCGTCTATCGCAAAAACGGCACGGTGAACTGGGACCCG GTCGACCAAACCGTCCTTGCCAACGAGCAAGTCATCGACGGACGCGGCTGGCGTTCGGGCGCGTTGATCGAAAAACGCGA AATCCCGATGTATTACTTCAAAATCACGGATTACGCCGAAGAGCTGCTCAACGACTTGGACAAGCTGGAACACTGGCCGG AACAAGTCAAAACCATGCAGCGCAACTGGATCGGCAAATCGCGCGGTATGACCGTGCGCTTCGCCGTTTCAGACGACAGC AAACAAGGCTTGGAAGGCGATTACGCGAAATTGCTGCAAGTTTATACCACCCGCCCCGACACGCTGATGGGTGCGACTTA TGTTGCCGTTGCCGCCGAGCATCCGCTGGCAGCCGCCGCAGCCGCCGACAAACCCGAATTGCAGGCATTTATTGCCGAAT GCAAAGCCGGTTCGGTTGCCGAAGCCGATATGGCGACGATGGAGAAAAAAGGCGTGCCGACCGGTCGCTACGTCGTCAAC CCGCTCAACGGCGACAAGCTGGAAGTGTGGATTGCCAACTATGTATTGTGGGGCTACGGCGACGGCGCAGTGATGGCGGT TCCGGCGCACGACGAACGCGATTTTGAGTTCGCCGCCAAATACAATCTGCCTAAAAAACAAGTCATTGCCGTCGGCGACA ACGCATTCGACGCAAACCGATGGCAAGAATGGTATGCCGACAAAGAAAACGGCGTATTGGTCAACAGCGGCGACTTGGAC GGCTTGGATTTTCAGACGGCATTCGATGCCGTTGCCGCCAAGCTGCAAAGCCAAGGCGCGGGCGAACCGAAAACCCAATA CCGCCTGCGCGACTGGGGCATTTCGCGCCAACGCTACTGGGGCTGCCCGATTCCCATCGTCCATTGCGAACAATGCGGCG ACGTACCCGTCCCTGCCGACCAATTGCCGGTCGTTTTGCCTGAAAACGTCGTACCCGACGGCATGGGTTCGCCGCTGGCA AAAATGCCCGAGTTTTACGAAACTGCCTGCCCATGCTGCGGCGGCGCGGCAAAACGCGAAACCGACACCATGGACACCTT CATGGAATCGAGCTGGTATTTCTTCCGCTATATGTCGCCAAAATTTTCAGACGGCATGGTCGATCCTGCCGCCGCGAAAT ACTGGGGCGCGGTCGACCAATACATCGGCGGCATCGAACACGCGATTTTGCACCTCTTGTACGCGCGTTTCTTCACCAAA CTGATGCGCGACGAAGGTCTAGTCAATGTTGACGAACCGTTTGAACGCCTGCTGACGCAAGGCATGGTCGTTTGCGAAAC CTACTACCGCGAAAACGACAAAGGCGGCAAAGATTGGATCAACCCCGCCGATGTCGAGCTGACGTTCGACGACAAAGGCC GCCCCATTTCCGCCGTCCTCAAAGCCGACGGGCTGCCCGTCGTCATCAGCGGCACGGAAAAAATGTCCAAGTCCAAAAAC AACGGCGTCGATCCGCAAGAACTGATTAACGCCTACGGCGCGGACACCGCCCGCCTGTTTATGATGTTCGCCGCACCGCC CGAACAGTCCCTCGAATGGAGCGACAGCGGCGTCGAAGGCGCACACCGCTTCCTGCGCCGCCTGTGGCGTACCGTTTACG AATACTTGAAGCAAGGCGAAGCGGTCAAAGCGTTCGCAGGCAGCCAAGACGGTTTGTCTAAAGAACTCAAAGACCTGCGC CACAAACTGCACGCGACCACTGCCAAAGTCAGCGACGACTACGGCCGCCGCCAGCAGTTCAACACCGCCATCGCCGCCGT GATGGAATTGCTCAACCAATACGACAAAACCGACACCGGCGGCGAACAAGGACGCGCCGTCGCCCAAGAAGTATTGGAAA CCGCCGTACGCCTGTTGTGGCCCATCGTGCCGCACATCTGCGAAACCCTGTGGAGCGAATTGAACGGCGCGAAACTGTGG GAAGCAGGCTGGCCGACAGTCGACGAAGCCGCCTTGGTCAAATCCGAAATCGAAGTGATGGTTCAAGTCAACGGCAAACT GCGCGGCAAAATCACTGTTGCCGCCGACGCATCCAAAGCCGACCTCGAAGCCGCCGCACTCGCCACCGAAGGCGCGGTGA AATTCATGGAAGGCAAACCGGCGAAGAAAATCATCGTCGTTCCCGGACGCTTGGTGAATATCGTCGTCTAA Protein sequence : MQEHYQPAAIEPAAQKKWDDARIFNVSEDASKPKYYCLSMFPYPSGKLHMGHVRNYTIGDVLSRFKLLNGFNVMQPMGWD AFGMPAENAAMKNNVAPAAWTYDNIEYMKTQLKSLGFAIDWARETATCKPEYYRWEQWLFTKLFEKGIVYRKNGTVNWDP VDQTVLANEQVIDGRGWRSGALIEKREIPMYYFKITDYAEELLNDLDKLEHWPEQVKTMQRNWIGKSRGMTVRFAVSDDS KQGLEGDYAKLLQVYTTRPDTLMGATYVAVAAEHPLAAAAAADKPELQAFIAECKAGSVAEADMATMEKKGVPTGRYVVN PLNGDKLEVWIANYVLWGYGDGAVMAVPAHDERDFEFAAKYNLPKKQVIAVGDNAFDANRWQEWYADKENGVLVNSGDLD GLDFQTAFDAVAAKLQSQGAGEPKTQYRLRDWGISRQRYWGCPIPIVHCEQCGDVPVPADQLPVVLPENVVPDGMGSPLA KMPEFYETACPCCGGAAKRETDTMDTFMESSWYFFRYMSPKFSDGMVDPAAAKYWGAVDQYIGGIEHAILHLLYARFFTK LMRDEGLVNVDEPFERLLTQGMVVCETYYRENDKGGKDWINPADVELTFDDKGRPISAVLKADGLPVVISGTEKMSKSKN NGVDPQELINAYGADTARLFMMFAAPPEQSLEWSDSGVEGAHRFLRRLWRTVYEYLKQGEAVKAFAGSQDGLSKELKDLR HKLHATTAKVSDDYGRRQQFNTAIAAVMELLNQYDKTDTGGEQGRAVAQEVLETAVRLLWPIVPHICETLWSELNGAKLW EAGWPTVDEAALVKSEIEVMVQVNGKLRGKITVAADASKADLEAAALATEGAVKFMEGKPAKKIIVVPGRLVNIVV |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| leuS | YP_281511.2 | leucyl-tRNA synthetase | Not tested | Not named | Protein | 3e-138 | 41 |
