Gene Information

Name : murD (NMC1745)
Accession : YP_975691.1
Strain : Neisseria meningitidis FAM18
Genome accession: NC_008767
Putative virulence/resistance : Unknown
Product : UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG0771
EC number : 6.3.2.9
Position : 1779570 - 1780907 bp
Length : 1338 bp
Strand : -
Note : UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation

DNA sequence :
ATGACGCTTGAAAACAAAAAAATCCTCGTCGCCGGACTCGGCGGTACGGGTATTTCCATGATTGCCTATCTGCGCAAAAA
CGGCGCGGAGGTGGCCGCTTATGATGCGGAGTTGAAGCCCGAGCGCGTGTCGCAAATCGGTAAGATGTTTGACGGGCTGG
TGTTTTACACAGGCCGTCTGAAAGATGCGCTGGACAACGGTTTCGATATTTTGGCACTCAGCCCCGGCATCAGCGAGCGT
CAGCCGGATATTGAGGCGTTCAAGCAAAACGGCGGACGCGTGTTGGGCGACATCGAATTGCTGGCGGACATTGTGAACCG
CCGGGGCGACAAGGTAATTGCGATTACCGGCAGCAACGGCAAAACCACGGTAACGAGCCTGGTCGGCTATCTCTGTATCA
AGTGCGGGCTGGATACCGTTATCGCGGGCAATATCGGCACGCCGGTTTTGGAGGCGGAATGGCAGCGCGAAGGCAAAAAG
GCGGACGTGTGGGTGTTGGAGCTTTCCAGCTTCCAACTGGAAAACACCGAAAGCCTGCGCCCGACGGCGGCGACGGTACT
GAATATTTCCGAAGACCATCTCGACCGCTACGACGACTTGCTCGACTACGCGCATACCAAAGCCAAGATTTTCCGTGGCG
ACGGTGTGCAGGTTTTGAATGCGGACGATGCGTTCTGCCGTGCCATGAAACGTGCCGGGCGCGAGGTAAAATGGTTTTCG
TTGGAACACGAAGCCGATTTTTGGTTGGAACGTGAGACAGGCCGCCTGAAACAAGGCAATGAAGATTTGATTGCCACGAA
AGACATTCCGTTGCAAGGCTTGCACAACGCCGCCAACGTCATGGCTGCCGTGGCTTTGTGCGAAGCCGTCGGTTTGCCGC
GCGAAGCATTGCTTGAACACGTCAAAACCTTCCAAGGCCTGCCGCACCGCGTGGAAAAAATCGGCAAGAAAAACGGCGTG
GTATTCATTGATGACAGCAAAGGCACGAATGTCGGCGCGACCGCCGCCGCGATTGCCGGTTTGCAAAATCCGCTCTTCGT
GATTTTAGGCGGCATGGGCAAAGGGCAGGACTTCACGCCTCTGCGCGACGCGCTTGCCGGCAAGGCAAAAGGCGTGTTCC
TGATCGGCGTTGATGCGCCGCAAATCCGCCGCGATTTGGACGGCTGCGGTCTGAATATGACCGACTGCGCCACTTTGGAA
GAAGCCGTTCAGACGGCATATGCCCAAGCCGAAGCGTGCGATATCGTGCTGCTCAGCCCGGCTTGTGCGAGTTTTGATAT
GTTTAAAGGCTACGCGCACCGTTCGGAAGTGTTTATCGAAGCGTTTAAGGCTTTGTGA

Protein sequence :
MTLENKKILVAGLGGTGISMIAYLRKNGAEVAAYDAELKPERVSQIGKMFDGLVFYTGRLKDALDNGFDILALSPGISER
QPDIEAFKQNGGRVLGDIELLADIVNRRGDKVIAITGSNGKTTVTSLVGYLCIKCGLDTVIAGNIGTPVLEAEWQREGKK
ADVWVLELSSFQLENTESLRPTAATVLNISEDHLDRYDDLLDYAHTKAKIFRGDGVQVLNADDAFCRAMKRAGREVKWFS
LEHEADFWLERETGRLKQGNEDLIATKDIPLQGLHNAANVMAAVALCEAVGLPREALLEHVKTFQGLPHRVEKIGKKNGV
VFIDDSKGTNVGATAAAIAGLQNPLFVILGGMGKGQDFTPLRDALAGKAKGVFLIGVDAPQIRRDLDGCGLNMTDCATLE
EAVQTAYAQAEACDIVLLSPACASFDMFKGYAHRSEVFIEAFKAL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00311 YP_008207776.1 UDP-N-acetylmuramoylalanine-D-glutamate ligase Not tested AbaR25 Protein 1e-57 42
BJAB0868_00315 YP_008211641.1 UDP-N-acetylmuramoylalanine-D-glutamate ligase Not tested AbaR26 Protein 1e-57 42