Gene Information

Name : thyA (NMC1624)
Accession : YP_975590.1
Strain : Neisseria meningitidis FAM18
Genome accession: NC_008767
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 1656566 - 1657360 bp
Length : 795 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGAAAGCCTATTTGGACTTGATGCGCCACGTCCTCGACAACGGTACGGACAAATCAGACCGCACCGGTACGGGCACGCG
CTCCGTATTCGGTTATCAGATGCGTTTTGACTTGGGCAAAGGTTTTCCGCTGCTGACGACCAAAAAGCTGCATCTGCGTT
CGATTATCCACGAGCTGCTTTGGTTTCTCAAAGGCGATACCAATATCAAATACCTAAAGGACAACAATGTTTCCATTTGG
GACGAGTGGGCGGACGAAAACGGCGACTTGGGCCCGGTTTACGGCTACCAGTGGCGTAACTGGCCCGCGCCCGACGGCAG
GCATATCGACCAAATCGCCAATGTGGTGGAACAAATTAAGAAAAACCCCGACTCGCGCCGCCTGATTGTATCGGCGTGGA
ATCCGGCTTTGGTCGACGAAATGGCCTTGCCGCCCTGCCACGCGCTGTTTCAGTTTTACGTTGCCGACGGCAAACTGTCC
TGCCAGCTTTACCAGCGTAGTGCAGATATTTTCCTTGGTGTGCCGTTTAATATTGCCAGCTACGCATTGTTGACCATGAT
GATGGCGCAAGTGTGCGGATTGGAGGCGGGCGAGTTTGTCCATACGTTTGGCGACGCGCATTTGTACCGCAACCATTTCG
AGCAGGCCGCATTGCAGTTGGAACGCGAACCGCGCGCCTTGCCAGTGATGAAAATCAATCCTGAAGTCAAAGATTTGTTT
TCCTTCAAGTTTGAAGATTTCGAGTTGGAAGGTTACGACCCCCATCCGCACATCAAGGCGGCAGTGTCGGTTTAG

Protein sequence :
MKAYLDLMRHVLDNGTDKSDRTGTGTRSVFGYQMRFDLGKGFPLLTTKKLHLRSIIHELLWFLKGDTNIKYLKDNNVSIW
DEWADENGDLGPVYGYQWRNWPAPDGRHIDQIANVVEQIKKNPDSRRLIVSAWNPALVDEMALPPCHALFQFYVADGKLS
CQLYQRSADIFLGVPFNIASYALLTMMMAQVCGLEAGEFVHTFGDAHLYRNHFEQAALQLEREPRALPVMKINPEVKDLF
SFKFEDFELEGYDPHPHIKAAVSV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 1e-82 64