Gene Information

Name : lysS (NMC1361)
Accession : YP_975360.1
Strain : Neisseria meningitidis FAM18
Genome accession: NC_008767
Putative virulence/resistance : Virulence
Product : lysyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG1190
EC number : 6.1.1.6
Position : 1350587 - 1352098 bp
Length : 1512 bp
Strand : -
Note : class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA

DNA sequence :
ATGAGCGAACAAAACCATCCGCAAACCGAGCCGCAGTTGGACGAAAACCAAATCATCGCCCTGCGCCGCGAAAAACTGCA
CAACATCCGCCAACAGCGCAACGCCTATCCCAACGACTTCAAACGCGACAGCTTCGCCGCCGATTTGCACGCCCAATACG
GCGAAATCGGCAAAGAAGAACTCGATCCGCAAGGCATTCCCGTCAAAGTGGCCGGCCGCATGATGCTGAAGCGTCAAATG
GGCAAGGCGAGCTTTGCCACCATTCAAGACGTGTCCGGGCAAATCCAGCTTTATCTGAACAACAAAGGCGTGAGCCAAGA
AGTTTTGGACGACTTCAACCATTGGGATTTGGGCGACATCGTCGGCGCGGAAGGCACTTTGTTCAAAACCAACCACGGCG
AACTGACCGTACGCGTGTCCGACATCCGCCTGTTGTCCAAATCCTTGCGTCCGCTGCCGGACAAACACAAAGGCTTGAGC
GATCAGGAAACCAAATACCGCCAACGCTATGTCGATTTGATTGCCAACGAAGAATCGCGCAATACCTTTATCAAACGCAG
CCAAATCATCCAATCCGTGCGTAATTTTATGGTGGGCGAGCATTATCTCGAAGTCGAAACCCCGATGATGCACCCGATTC
CCGGCGGCGCGACGGCAAAACCCTTCGTTACTCATCACAATGCCTTAGATATTCCGCTTTACCTGCGTATCGCGCCTGAG
CTGTATTTGAAACGCCTGGTTGTCGGCGGCTTGGAACGCGTGTTTGAAATCAACCGCAGCTTCCGCAACGAAGGCATGTC
CGTGCGCCACAACCCCGAATTTACGATGATTGAATTTTACGAAGCCTTCTCCGACTACGAACGTATGATGCAGATGGCGG
AAGACATCATCCGCAACGCATCGCGCACAGTAAACGGTACGGCAAACATCACTTACAATGGCAAAGAAGTCGATTTGGAA
AGCCCGTTCGAGCGTCTGACCATCCTCGAAGCCATCAAAAAATACAATCCGCACTACACCGACGAGCAGTTGAACGATGC
GGAATGGCTGAAAAAAGAAATCGTCAAACACGGTGAAAGCCTGCCGCCGTCCCCGGGCATCGGCAGCCTGCAACTCGCGC
TGTTTGAAGGTTGCGCCGAGGGCAAGCTGTGGAACCCGACTTTCATCATCGATTACCCGGTCGAAGTTTCCCCGTTGGCG
CGCGCTTCGGATACCAAACAAGGTCTGACCGAACGTTTCGAATTGTTCGTTGTCGGCCGCGAACTGGCAAACGGCTATTC
CGAGTTGAACGACCCCGAAGACCAAGCCGAACGCTTCAAAGCGCAAGTGGCGCAAAAAGACGCGGGCGACGACGAAGCGA
TGCACTACGATGCCGACTACATCCGCGCGATGGAGTTCGGTCTGCCGCCGACTGGCGGTTGCGGTATCGGCATCGACCGC
TTGGTAATGTTGCTGACCGATTCGCAAACCATCCGTGACGTGATTCTGTTCCCGCAGATGCGCCCCGAGTAA

Protein sequence :
MSEQNHPQTEPQLDENQIIALRREKLHNIRQQRNAYPNDFKRDSFAADLHAQYGEIGKEELDPQGIPVKVAGRMMLKRQM
GKASFATIQDVSGQIQLYLNNKGVSQEVLDDFNHWDLGDIVGAEGTLFKTNHGELTVRVSDIRLLSKSLRPLPDKHKGLS
DQETKYRQRYVDLIANEESRNTFIKRSQIIQSVRNFMVGEHYLEVETPMMHPIPGGATAKPFVTHHNALDIPLYLRIAPE
LYLKRLVVGGLERVFEINRSFRNEGMSVRHNPEFTMIEFYEAFSDYERMMQMAEDIIRNASRTVNGTANITYNGKEVDLE
SPFERLTILEAIKKYNPHYTDEQLNDAEWLKKEIVKHGESLPPSPGIGSLQLALFEGCAEGKLWNPTFIIDYPVEVSPLA
RASDTKQGLTERFELFVVGRELANGYSELNDPEDQAERFKAQVAQKDAGDDEAMHYDADYIRAMEFGLPPTGGCGIGIDR
LVMLLTDSQTIRDVILFPQMRPE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed CAD66193.1 putative lysil-tRNA synthetase LysU Not tested PAI III 536 Protein 1e-125 52

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
lysS YP_975360.1 lysyl-tRNA synthetase VFG1668 Protein 6e-126 52