Gene Information

Name : guaA (Maqu_1727)
Accession : YP_958998.1
Strain : Marinobacter aquaeolei VT8
Genome accession: NC_008740
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1929082 - 1930659 bp
Length : 1578 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGGCCCAGAACATTCACGACCACCGTATCCTGATTCTCGATTTCGGTTCCCAGTACACCCAGTTGATCGCTCGTCGCGT
TCGTGAAATCGGGGTTTACTGCGAGATCAAGGCATTCGATATCACCGATGACGAACTTAACGAGTTCAATCCCAAGGGTA
TTATTCTGGCGGGCGGCCCGGAATCGGTCACCCAGCTCGGTGGCCCGCGTGCCCCGGAAGGTCTGTTCGATCGTGGTATT
CCGGTGCTGGGTATCTGCTACGGCATGCAGACCATGGCAGAGCAGCTTGGCGGTCGGGTTGCCAGTTCCGAGAAGCGGGA
GTTCGGTTATGCCCAGGTGAAGGTTCGTGCCAAGGGCCCGCTGCTGGCAGACATTACCGACCACCTGACGCCGGCTGGTG
ATTCCCTGCTGGACGTCTGGATGAGCCACGGCGACAAAGTGGTCGCCATGCCGGAAGGCTTCGAGCTGTTGGCCTCCACT
GAGAGCGCGCCGATTGCTGCCATGCAGGACCTGAGCCGCAACCTGTACGGCGTTCAGTTCCACCCGGAAGTGACTCACAC
CCTGCAGGGCAAGCGCATCCTCGAGCACTTTGTCCTGACCATCTCCGGCTGTGAGGCTCTGTGGACCCCGGCCAAGATCG
TCGACGATGCCGTTCGGCAGATTCGCGAGCAGGTGGGTTCCGACAAGGTGCTGTTGGGCCTGTCCGGTGGTGTGGATTCT
TCGGTTACGGCGGCGTTGTTGCATAAAGCCATCGGTGACCAGCTTACCTGCGTGTTCGTGGACAACGGCCTGCTGCGCCT
GCACGAAGGCGATCAGGTGATGGACATGTTTGCCAGTAACATGGGCGTTAAGGTTATCCGTGTAGACGCTGAAGACTTGT
TCCTGTCCAAGCTCAAGGGCGTGAACGATCCGGAGCAGAAGCGCAAGATCATCGGTAATACCTTCATTGACGTGTTCGAC
GACGAAGCGGCCAATATCAAAGACGTGAACTGGCTTGCCCAGGGCACCATCTATCCGGACGTGATTGAATCCGCTGCGTC
CAAAACCGGTAAAGCCCATGTCATCAAGTCCCACCATAATGTGGGTGGCTTGCCGGAAACCATGAAGATGAAACTGGTAG
AGCCGCTGCGCGAGCTGTTCAAGGACGAAGTCCGCAAGATCGGCCTCGAGCTTGGCCTGCCGTACGACATGGTCTACCGC
CACCCGTTCCCGGGGCCGGGGCTGGGGGTTCGTATCCTCGGCGAGGTCAAGAAAGAGTATGCGGACATTCTGCGTCGTGC
CGACGCGATCTTCCTGGAAGAACTGCATCGTGCTGACCTGTACCACAAGACCAGCCAGGCCTTTGCCGTGTTCCTGCCGG
TGAAATCCGTGGGTGTAGTGGGTGATGCCCGCCGCTACGAATACGTGATCGCGATCCGTGCCGTGGAAACCGTGGACTTT
ATGACCGCACGCTGGGCGCGGCTCCCGTACGAACTGCTGGAAACCGTATCCAACCGGATTATCAACGAGATTTCCGGTGT
ATCACGGGTGACCTACGATATTTCGTCCAAGCCGCCCGCAACCATTGAATGGGAGTGA

Protein sequence :
MAQNIHDHRILILDFGSQYTQLIARRVREIGVYCEIKAFDITDDELNEFNPKGIILAGGPESVTQLGGPRAPEGLFDRGI
PVLGICYGMQTMAEQLGGRVASSEKREFGYAQVKVRAKGPLLADITDHLTPAGDSLLDVWMSHGDKVVAMPEGFELLAST
ESAPIAAMQDLSRNLYGVQFHPEVTHTLQGKRILEHFVLTISGCEALWTPAKIVDDAVRQIREQVGSDKVLLGLSGGVDS
SVTAALLHKAIGDQLTCVFVDNGLLRLHEGDQVMDMFASNMGVKVIRVDAEDLFLSKLKGVNDPEQKRKIIGNTFIDVFD
DEAANIKDVNWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPETMKMKLVEPLRELFKDEVRKIGLELGLPYDMVYR
HPFPGPGLGVRILGEVKKEYADILRRADAIFLEELHRADLYHKTSQAFAVFLPVKSVGVVGDARRYEYVIAIRAVETVDF
MTARWARLPYELLETVSNRIINEISGVSRVTYDISSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 4e-131 53
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 3e-131 53
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-131 52
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-116 49