Gene Information

Name : Mvan_4670 (Mvan_4670)
Accession : YP_955451.1
Strain : Mycobacterium vanbaalenii PYR-1
Genome accession: NC_008726
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 5009176 - 5010357 bp
Length : 1182 bp
Strand : -
Note : catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine

DNA sequence :
ATGAGTGAGCAGCGCAGCGCCTCGGACCACTATCGGGCCTTCGGCCCGGCGACCAGGGCCATTCACGCGGGGTACCGGCC
CGATCCCGCGACGGGGGTCGTCAACCCCCCGATCTACGCCAGCTCGACGTTCGCCCAGGACGGTGTCGGCGGGCTGCGCG
GCGGCTTCGAGTACTCGCGCACCGGCAACCCCACCCGCTCCGTACTGGAGGGTGCACTGGCGGCGATGGAGGGGGCGTCC
CACGGACGCGCGTTCAGCTCCGGCATGGCGGCCACCGACTGCGTGCTGCGGGCCGTGCTGCGCCCCGGCGACCACCTGGT
GATCCCCGACGATGCCTACGGCGGCACCTTCCGGCTGATCGACAAGGTGTTCAGCCTGTGGGGCATCAGCTACACCGCGG
TGGCGCTGGGGGACCTCGACCGGGTGCGCGCGGCCGTCACCGACCGCACCAAGCTGATCTGGATCGAGACCCCGACCAAC
CCGCTGCTGTCCATCGCCGACATCGCCGCCATCGCCGAGGTGGGCGCCGCCACCGGCGCGAAGGTGCTGGTGGACAACAC
GTTTGCCTCACCGGCGCTGCAGCAGCCACTGGCCCTGGGCGCCGACATCGTGCTGCACTCGACGACCAAGTACATCGGCG
GGCACTCCGACGTCGTCGGCGGCGCGCTGCTGACCAACGACGAAGCCCTCGATGACGCGTTCGCATTCCTGCAGAACGGC
GCCGGTGCGGTACCGGGACCGTTCGACGCGTACCTGACCATTCGTGGACTCAAGACCCTGCCCCTGCGGATGCAGCGGCA
CAGCGAGAACGCCGCCGCGATCGCCGAGTTCCTCGACGGACACCCCGCCGTCACGACGGTGCTGTACCCGGGCCTGCCCA
GCCACCCCAACCACGACGTCGCCGCCCGGCAGATGAGCGGATTCGGCGGAATGGTGTCGGTACGGCTGCGCGGTGGCCCG
CAGGCCGCGCGCGACTTCTGCGCCCGCACCGAGATCTTCATCCTCGCCGAGTCGCTGGGCGGCGTGGAGTCGCTGATCGA
GTATCCGGGCGCGATGACGCACGCCTCCACCGCCGGTTCGCAGCTGGAGGTGCCCGACGACCTGGTGCGGCTGTCCGTCG
GCATCGAGGACGTCGCCGACCTGCTCGGAGATGTCGAGCAGGCGCTGGGCGCGCCCGGCTGA

Protein sequence :
MSEQRSASDHYRAFGPATRAIHAGYRPDPATGVVNPPIYASSTFAQDGVGGLRGGFEYSRTGNPTRSVLEGALAAMEGAS
HGRAFSSGMAATDCVLRAVLRPGDHLVIPDDAYGGTFRLIDKVFSLWGISYTAVALGDLDRVRAAVTDRTKLIWIETPTN
PLLSIADIAAIAEVGAATGAKVLVDNTFASPALQQPLALGADIVLHSTTKYIGGHSDVVGGALLTNDEALDDAFAFLQNG
AGAVPGPFDAYLTIRGLKTLPLRMQRHSENAAAIAEFLDGHPAVTTVLYPGLPSHPNHDVAARQMSGFGGMVSVRLRGGP
QAARDFCARTEIFILAESLGGVESLIEYPGAMTHASTAGSQLEVPDDLVRLSVGIEDVADLLGDVEQALGAPG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 5e-72 47
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 7e-71 46
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 4e-53 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Mvan_4670 YP_955451.1 cystathionine gamma-synthase BAC0207 Protein 2e-62 44