Gene Information

Name : Mvan_3850 (Mvan_3850)
Accession : YP_954637.1
Strain : Mycobacterium vanbaalenii PYR-1
Genome accession: NC_008726
Putative virulence/resistance : Virulence
Product : AMP-dependent synthetase and ligase
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : -
Position : 4113062 - 4114714 bp
Length : 1653 bp
Strand : +
Note : PFAM: AMP-dependent synthetase and ligase; KEGG: mmc:Mmcs_3471 AMP-dependent synthetase and ligase

DNA sequence : 
ATGAACACTGGATTACCGGCCGATCAAGGCAATGACCTGACCCGCGGCTTCGTCCCCTTCCCCCCGGACAGAGCCGAGGT
GTACCGCCGGGCCGGCTACTGGACGGGCCGTCCGCTCGACTCGATCCTCACCGAGGCGGCTGCGACGTGGCCCGACAAAC
CGGCGGTCATCGACTCCGCACAGACGTACACGTTCAGAGAACTCGACGCGGCGGCCGACCGGGTGGCCGCCGGGCTGGCC
GCCCTGGGGATCCGCCCCGGCGACCGGGTGCTGCTGCAGCTGCCGAACTCCTGCCAGTTCGCGATCGCCCTGTTCGGGCT
GCTCCGCGCGGCAGCGGTTCCGGTGATGTGCCTGCCCGGGCACCGGACCGCCGAGCTCGGCCACTTCGCCGAGGTCAGCG
GAGCGGTCGCGCTCATCGTCCCCGACGAGGCGGGCGGCTTCGACTACCGCGACATGGCCGGCCGACTCGCCGCCGAGCAC
CCGTCGCTGCAGCACGTGATCGTCGACGGCGAGAACGGACCGTTCGTCGCATGGTCGTCGATCCGCGATTTCGACGGACC
TGCCGTCGAGCGTGCGGCGGTGGACCCGGGTCTTCCCGCGCTACTGCTGGTCTCCGGCGGGACCACCGGTCTGCCGAAGC
TGATCGCGCGCACTCACGACGATTACGTCTACAACGCCGTCGCGTCCGCACAGGCCTGCGAGATGACCGCCGAAGACGCG
TACCTCGTCGCCCTGCCCGCCGGCCACAACTTCCCGCTGGCGTGCCCGGGGATGCTCGGCTCGATGACCGTCGGCGCCCC
CACCGTCTTCACCGCGGATCCCAGCCCGGAGAACGCCTTCGCGCTGATCGACAAGTTCAGGATCACCGTCACCGGGCTGG
TCAACGCGCTGGCGAAGTTGTGGGCGCAGGCCTGCGAATGGGAACCGGTGCTGCCGACCTCGCTGCGGTTCGTGCAGGTC
GGCGGATCCCGGATGAGCCCCGAGGAGGCCCGTTTCATTCTCGAGCGGCTGACGCCCGGCATGTCGCAGATCTTCGGCAT
GGCCGAGGGAATGCTGAACTTCACCAGGCCCGGCGACCCCGAGGACGTGGTGGTGCACACGCAGGGCCGTCCCATGTCCC
CGCACGACGAGGTGCGGGTGGTCGACGAGAGCGGCGACGGGGTGCCGCCCGGGGAGGAGGGAGAGCTGTTGGTGCGCGGG
CCCTACACCCTCTACGGCTACTACCGCGACGACGACGCGAACGCCCGCTCGTTCTCCCCGGACGGCTTCTACCGCACGGG
CGATCGGGTGCGAATCTTCGCCGACGGTCCACGGGCCGGGTATGTGGAAGTGGTCGGCCGCATCAAGGACGTCATCCACC
GCGGGGGCGAAACCGTGTCCGCGACGGATCTGGAAGACCATCTGCACACCCATCCGGCGATCTACGCGGCGGCCGCCGTG
GCCCTACCTGATGAGTACCTCGGTGAGAAGATCTGCGCCGCAGTCGTTTTCCGTGGTAAGCCGATCACGCTGGCCGAGTT
GAACGCCTTTCTCGACGAGCGTGGGGCATCCAAGCACGCACGTCCCGACGTGCTGATGCCGGTGCGGTCGCTGCCGACGA
CGGCGGTGGGCAAGGTGGACAAGAAGCAGTTGGGGGCACAGCTGACGTCGTGA

Protein sequence : 
MNTGLPADQGNDLTRGFVPFPPDRAEVYRRAGYWTGRPLDSILTEAAATWPDKPAVIDSAQTYTFRELDAAADRVAAGLA
ALGIRPGDRVLLQLPNSCQFAIALFGLLRAAAVPVMCLPGHRTAELGHFAEVSGAVALIVPDEAGGFDYRDMAGRLAAEH
PSLQHVIVDGENGPFVAWSSIRDFDGPAVERAAVDPGLPALLLVSGGTTGLPKLIARTHDDYVYNAVASAQACEMTAEDA
YLVALPAGHNFPLACPGMLGSMTVGAPTVFTADPSPENAFALIDKFRITVTGLVNALAKLWAQACEWEPVLPTSLRFVQV
GGSRMSPEEARFILERLTPGMSQIFGMAEGMLNFTRPGDPEDVVVHTQGRPMSPHDEVRVVDESGDGVPPGEEGELLVRG
PYTLYGYYRDDDANARSFSPDGFYRTGDRVRIFADGPRAGYVEVVGRIKDVIHRGGETVSATDLEDHLHTHPAIYAAAAV
ALPDEYLGEKICAAVVFRGKPITLAELNAFLDERGASKHARPDVLMPVRSLPTTAVGKVDKKQLGAQLTS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 1e-86 43
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-86 43
ybtE CAA21394.1 - Virulence HPI Protein 3e-87 43
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 3e-87 43
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 3e-87 43
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 3e-87 43
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 3e-87 43
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 3e-87 43
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 4e-87 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Mvan_3850 YP_954637.1 AMP-dependent synthetase and ligase VFG1817 Protein 1e-165 64
Mvan_3850 YP_954637.1 AMP-dependent synthetase and ligase VFG0168 Protein 2e-82 42
Mvan_3850 YP_954637.1 AMP-dependent synthetase and ligase VFG0932 Protein 2e-78 41