Gene Information

Name : tpx (Mvan_2971)
Accession : YP_953782.1
Strain : Mycobacterium vanbaalenii PYR-1
Genome accession: NC_008726
Putative virulence/resistance : Virulence
Product : thiol peroxidase
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG2077
EC number : -
Position : 3142041 - 3142538 bp
Length : 498 bp
Strand : -
Note : antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein

DNA sequence : 
ATGGCACAGATAACTTTGCGTGGAAACCCGATCAACACCGTTGGCGAACTGCCCTCCGTCGGATCTGCCGCACCCGGCTT
CACACTCACCGGAACGGATCTCGGCACGGTCGGTGACGACCAGTTCCGCGGCAAACCGCTGCTGCTCAACATCTTCCCGT
CGATCGACACCCCGGTGTGCGCCGCCAGCGTTCGCAGGTTCAACGAGAGCGCCGCATCCGCAGGGGTGTCGGTGCTGTGC
GTGTCGAAGGATCTGCCGTTCGCGCAGAAGCGCTTCTGCGGCGCCGAGGGCATCGAGAACGTGACGACGGCATCGGCGTT
CCGCGACGGCTTCGGCGACGACTTCGGCGTCACGATCACCGACGGACCGATGGCCGGACTGCTGGCGCGCGCTGTCGTGG
TGGTCGGCGCTGACGGAAATGTCGCCTACACCGAGCTGGTGCCCGAGATCGGCCAGGAGCCGGATTACGACGCGGCCCTG
GCGGCGCTGCGCTCCTGA

Protein sequence : 
MAQITLRGNPINTVGELPSVGSAAPGFTLTGTDLGTVGDDQFRGKPLLLNIFPSIDTPVCAASVRRFNESAASAGVSVLC
VSKDLPFAQKRFCGAEGIENVTTASAFRDGFGDDFGVTITDGPMAGLLARAVVVVGADGNVAYTELVPEIGQEPDYDAAL
AALRS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tpx NP_230472.1 thiol peroxidase Virulence VPI-1 Protein 1e-22 46
tpx YP_001216305.1 thiol peroxidase Not tested VPI-1 Protein 1e-22 46
tagD AAK20781.1 toxR-activated gene D protein Virulence VPI Protein 9e-23 46
tagD AAK20751.1 toxR-activated gene D protein Virulence VPI Protein 7e-23 46

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
tpx YP_953782.1 thiol peroxidase VFG0087 Protein 4e-23 46