Gene Information

Name : guaA (Mvan_1516)
Accession : YP_952354.1
Strain : Mycobacterium vanbaalenii PYR-1
Genome accession: NC_008726
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1603470 - 1605038 bp
Length : 1569 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
GTGGAATCTGCAACCCCCCGCCCGGTCCTGGTCGTCGACTTCGGCGCGCAGTACGCGCAGCTGATCGCCCGACGCGTGCG
CGAGGCGCGGGTGTTCTCCGAGGTCATCCCGCACACCACCTCCGTCGAGGAGATCAAGGCGCGCAACCCGCGCGCGGTCG
TGCTGTCGGGTGGGCCGGCCAGCGTGTATGCCGACGGCGCGCCCCAGCTCGATCCCGCTCTGTTCGACCTCGACGTCCCG
GTGTTCGGTATCTGCTACGGATTTCAGGCCATGGCGCAGGCGCTAGGCGGCACCGTCGCGCACACCGGCACCAGCGAGTA
CGGTCGCACCGAGCTGAAAGTCGCTGGCGGGCAACTGCATACCGATCTGCCCGAGACCCAGCCGGTGTGGATGAGCCACG
GCGACGCGGTGACGGCCGCACCCGAGGGCTTCGAGGTGGTCGCGACGAGTGCCGGCGCACCGGTCGCGGCGTTCGAGAAT
CGGGCCAGGCGGCTGGCCGGCGTGCAGTACCACCCCGAGGTGATGCACAGCCCGCACGGCCAGCAGGTGCTCAGCCGGTT
CCTGCACGAGTTCGCGGGCATCGACGCCACCTGGACGCCGGCCAACATCGCCGAGGCCCTCGTCGAGCAGGTGCGCACCC
AGATCGGTGACGGTCGCGCGATCTGCGGCCTCTCCGGTGGTGTCGACTCCGCGGTGGCGGCCGCGCTGGTGCAGCGTGCC
ATCGGCGACCGGCTCACCTGCGTGTTCGTCGACCACGGGCTGCTGCGCTCGGGCGAGCGGGCGCAGGTTCAGCGTGATTT
CGTCGCCGCCACCGGGGCCAACCTGGTGACCGTCGACGTGGCAGACCGGTTCCTGGAGGCGCTCTCGGGGGTCACCAACC
CCGAAGGCAAGCGCAAGATCATCGGTCGGGAGTTCATCCGTGCGTTCGAGGGCGCGGTGCGCGATGCGCTCGAGAGTCAG
GACGGCTCCGATGTGCCTGTCGAATTCCTGGTGCAGGGCACGCTGTACCCGGACGTGGTCGAGTCCGGTGGCGGTTCCGG
CACCGCCAATATCAAGAGTCACCACAACGTCGGCGGCCTTCCCGACGACCTGAAGTTCACCCTCGTCGAGCCGCTGCGGC
TGCTGTTCAAGGACGAGGTGCGTGCTGTCGGCCGCGAGCTCGGATTGCCCGAGGAAATCGTTGCGCGCCAACCGTTCCCG
GGTCCCGGTCTGGGCATCCGGATCGTCGGTGAGGTCACCGCCGAGCGGCTGGACACGCTGCGCCGGGCAGATGCCATCGC
CCGCGAGGAGCTGACCTCGGCAGGGTTGGATCACCAGATCTGGCAGTGCCCGGTGGTGCTGCTGGCCGACGTCCGGTCGG
TGGGTGTGCAGGGTGACGGGCGCACCTACGGCCACCCCATCGTGTTGCGTCCGGTGTCAAGCGAGGACGCGATGACGGCG
GACTGGACGCGGGTTCCTTACGAAGTGCTGGAACGGATTTCGACCCGGATCACCAACGAGGTGCGTGAGGTGAACCGGGT
GGTGCTCGACGTCACCAGCAAGCCGCCGGGCACCATCGAGTGGGAGTGA

Protein sequence :
MESATPRPVLVVDFGAQYAQLIARRVREARVFSEVIPHTTSVEEIKARNPRAVVLSGGPASVYADGAPQLDPALFDLDVP
VFGICYGFQAMAQALGGTVAHTGTSEYGRTELKVAGGQLHTDLPETQPVWMSHGDAVTAAPEGFEVVATSAGAPVAAFEN
RARRLAGVQYHPEVMHSPHGQQVLSRFLHEFAGIDATWTPANIAEALVEQVRTQIGDGRAICGLSGGVDSAVAAALVQRA
IGDRLTCVFVDHGLLRSGERAQVQRDFVAATGANLVTVDVADRFLEALSGVTNPEGKRKIIGREFIRAFEGAVRDALESQ
DGSDVPVEFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGLPEEIVARQPFP
GPGLGIRIVGEVTAERLDTLRRADAIAREELTSAGLDHQIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTA
DWTRVPYEVLERISTRITNEVREVNRVVLDVTSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA NP_938969.1 GMP synthase Not tested Not named Protein 0.0 78
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 3e-136 51
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 3e-136 51
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 5e-136 51