Gene Information

Name : merA (AAur_pTC10241)
Accession : YP_950110.1
Strain :
Genome accession: NC_008712
Putative virulence/resistance : Resistance
Product : mercuric reductase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1249
EC number : 1.16.1.1
Position : 253969 - 255411 bp
Length : 1443 bp
Strand : +
Note : identified by similarity to GB:AAS20018.1; match to protein family HMM PF00070; match to protein family HMM PF01266; match to protein family HMM PF02852; match to protein family HMM PF07992; match to protein family HMM TIGR02053

DNA sequence : 
ATGCCTGAGGCAGCACCGGATTTTGATTTGGCCGTAATCGGTTCCGGCGGTGGTGCCTTCGCCGCCGCCATCCGGGCCAC
GAATCTGGGCAAGCGGGTGGTCATGATCGAACGCTCCACGGTGGGCGGGACCTGTGTGAACACCGGGTGTGTTCCTTCCA
AGGCCCTGCTGGCCGCCGCCGACGCCAGACATGTGGCTTTGGACGGGACAGGAAGGTTCCCCGGGATCAGCACCACCGCC
GCACCAGTGGATATGGGTGCGCTCATTGACGGGAAACGCTCTCTGGTCGAAGGTATGCGCTCGGATAAGTACGTGGATCT
GGCCGCCGAGTATGGATGGGACCTGCGTCAGGGTAGCGCGGTGTTCGCTGGCACCCCCCAGGAACCGGCTTTGGAGATCA
CCCGGCCTGACGGCGGCCGCGACTCCCTAACCGCTGCCCATTATCTGGTTGCGACTGGTTCGGCTCCGTGGGCACCCCCG
GTGCCTGGACTGGAGGAGGTTGACTACCTGACCTCGACCACAGCCATGGAACTGGGCGAAGTGCCCGAGTCCCTGATCGT
CTTCGGCGGCGGATACGTCGCGCTAGAACAAGCTCAGCTTTTTGCCCGCCTCGGATCTAAAGTGACCTTGCTGGCCCGCT
CCCGGCTTGCCTCGCACGAGGAACCCGAAGCATCCCGTGCCCTGATGGGCGTCTTCGCCGATGAGGGCATCCGCGTGATC
CGCCGCGCCACCGTGACATCGATCCGCGCTAACGCGTCAGGGGAAGAAGTGACTGTCACCGCCACGGTGGCCGGGGGCCA
CGAGGAATTCCGTGCCGCGAAGCTGTTGGTTGCCACCGGGCGTCGTGCCGTCACCAACGGGCTTAATCTGGATGCCGTCG
GCGTTAAAACCGGTAACACCGGCCAGATTCTGGTTGAGAACACGCTGGCAAGCTCCAACCCCAGGATCTGGGCCGCCGGG
GATGTGACCGGGCACAGGGAATTCGTCTACGTCGCGTCCGCTCACGGGACCCTGATGGTGGAGAACGCGTTCAACGACGC
CGGGCGCGAGGTCGACTACCGGCACCTTCCCCGCGTGACGTTCACCAGCCCGGCTCTGGCCGCCGTCGGTATGACCGATA
AGGAAGCGAATGAAGCGGGGATCCGGTGTGAGTGCAGGGTCCTGCCACTGGAGTATGTTCCGCGGGCGCTGGTGAACCGG
GACACCCGCGGGTTCATCAAAATCGTCGCTAATAACAGCACAGGCCGAATCGTCGGGATCACCGCGGTCGGCAAGGAGGC
CGGGGACCTGGCCGCGGCCGGCGTGTACATCCTTGAGGCGGGCATGACCGTGGACCAGGTGGCGAACCTCTGGTCCCCGT
ACCTGACCATGGCCGAAGGTATCAAAATCGCCGCACAGTCTTTCACCACAGACGTCTCCAAACTCTCCTGCTGCGCCTCC
TAA

Protein sequence : 
MPEAAPDFDLAVIGSGGGAFAAAIRATNLGKRVVMIERSTVGGTCVNTGCVPSKALLAAADARHVALDGTGRFPGISTTA
APVDMGALIDGKRSLVEGMRSDKYVDLAAEYGWDLRQGSAVFAGTPQEPALEITRPDGGRDSLTAAHYLVATGSAPWAPP
VPGLEEVDYLTSTTAMELGEVPESLIVFGGGYVALEQAQLFARLGSKVTLLARSRLASHEEPEASRALMGVFADEGIRVI
RRATVTSIRANASGEEVTVTATVAGGHEEFRAAKLLVATGRRAVTNGLNLDAVGVKTGNTGQILVENTLASSNPRIWAAG
DVTGHREFVYVASAHGTLMVENAFNDAGREVDYRHLPRVTFTSPALAAVGMTDKEANEAGIRCECRVLPLEYVPRALVNR
DTRGFIKIVANNSTGRIVGITAVGKEAGDLAAAGVYILEAGMTVDQVANLWSPYLTMAEGIKIAAQSFTTDVSKLSCCAS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SE0085 NP_763640.1 dihydrolipoamide dehydrogenase Not tested SCCpbp4 Protein 2e-88 44
merA BAB47642.1 mercuric reductase Not tested Type-III SCCmec Protein 2e-88 44
merA ABQ57371.1 MerA Not tested SGI1 Protein 3e-73 43
merA AGK07021.1 MerA Not tested SGI1 Protein 3e-73 43
merA AGK07079.1 MerA Not tested SGI1 Protein 3e-73 43
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 5e-71 43
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 1e-70 42
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 9e-71 42
merA AFG30120.1 MerA Not tested PAGI-2 Protein 9e-71 42
merA ACN81005.1 MerA Hg(II) mercuric ion reductase Not tested AbaR5 Protein 9e-72 42
merA CAJ77060.1 Mercuric ion reductase Not tested AbaR1 Protein 1e-71 42
unnamed ABR13401.1 mercuric reductase Not tested PAGI-5 Protein 2e-68 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
merA YP_950110.1 mercuric reductase BAC0651 Protein 1e-88 44
merA YP_950110.1 mercuric reductase BAC0224 Protein 7e-86 44
merA YP_950110.1 mercuric reductase BAC0652 Protein 1e-73 43
merA YP_950110.1 mercuric reductase BAC0653 Protein 4e-69 41