Gene Information

Name : thyA (AAur_2992)
Accession : YP_948699.1
Strain : Arthrobacter aurescens TC1
Genome accession: NC_008711
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 3271040 - 3271843 bp
Length : 804 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
GTGAGCATCCCCACCCCTTATGAAGACCTTCTGCGCGACGTCATGGCTAACGGCACGCACAAGTCGGACCGCACCGGAAC
CGGAACGCGCAGCGTTTTCGGCCGCCAGTTGCGGTTCGATCTTGCCGAAAGCTTCCCCCTGATCACCACCAAGCGGGTCC
ACTTCAAGTCCGTGGCGGTGGAGCTCCTGTGGTTCCTGCGCGGCGATTCGAACGTGAAGTGGATGCAGGACCAGGGCGTC
TCCATCTGGGACGAATGGGCGGATGCCGACGGCGAGCTCGGTCCCGTCTATGGCGTGCAGTGGCGAAGCTGGCCCACCCC
CGACGGTGGACACATCGACCAGATCTCCGAGCTCATGACCAATCTGGCAGCCAACCCGGATTCCCGCAGGCACATCGTGT
CCGCATGGAACGTCTCCGAACTCAAGGACATGGCATTGCCGCCGTGCCATGCGTTCTTCCAGTTCTATGTTGCGGACGGC
AAATTGTCCTGCCAGCTGTACCAGCGCTCCGCGGACACCTTCCTGGGCGTCCCCTTCAACATTGCCTCCTACGCCCTGCT
CACCCGCATGGTGGCGCAGCAGCTGGGGCTCGAGCCGGGCGAATTCGTCTGGACCGGCGGAGACGTCCACGTCTATGACA
ACCACGTGGACCAGGTTGCCGAGCAACTCAGCCGGGAACCGTATGAATACCCGCAGCTGAAAATCCTCCGCAAGCCGGAC
TCCATCTTCGACTACACGCTGGATGACTTCGAGGTTGTGGACTACCGCCACCACCCCACCATCAAGGCTCCGATCGCGGT
ATGA

Protein sequence :
MSIPTPYEDLLRDVMANGTHKSDRTGTGTRSVFGRQLRFDLAESFPLITTKRVHFKSVAVELLWFLRGDSNVKWMQDQGV
SIWDEWADADGELGPVYGVQWRSWPTPDGGHIDQISELMTNLAANPDSRRHIVSAWNVSELKDMALPPCHAFFQFYVADG
KLSCQLYQRSADTFLGVPFNIASYALLTRMVAQQLGLEPGEFVWTGGDVHVYDNHVDQVAEQLSREPYEYPQLKILRKPD
SIFDYTLDDFEVVDYRHHPTIKAPIAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 1e-91 72
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 2e-53 43