Gene Information

Name : Mkms_0640 (Mkms_0640)
Accession : YP_936646.1
Strain : Mycobacterium sp. KMS
Genome accession: NC_008705
Putative virulence/resistance : Virulence
Product : aldehyde dehydrogenase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1012
EC number : 1.2.1.3
Position : 699315 - 700838 bp
Length : 1524 bp
Strand : +
Note : PFAM: aldehyde dehydrogenase; KEGG: mmc:Mmcs_0627 aldehyde dehydrogenase (NAD+)

DNA sequence :
ATGACTGTCTACGCACGCCCCGGTGCCGCGGATGCATTGATGGCTTTCGAGTCGCGGTACGGCAACTTCATCGGCGGCGA
GTGGGTCGCGCCCGCGGGCGGGGAGTACTTCGAGAACCTGACACCGGTGACGGGACAGACGTTCTGCGAGATCCCGCGCT
CGACGGAGGCCGACATCGACAAGGCGCTCGACGCGGCGCACGGCGCGGCGACGGCGTGGGGCAAGACCTCGCCGGGGGAG
CGGGCGCAGATCCTGATCAAGATCGCCGACCGGTTGGAGGCCAACCTCGAATCGCTCGCGCTCGCCGAATCGTGGGACAA
CGGCAAGCCGATCCGCGAGACGCTGAACGCCGACATCCCGTTGGCGATCGACCACTTCCGCTACTTCGCCGGTGCGATCC
GCGCCCAGGAGGGTGCGCTGTCGCAGATCGACGAGGACACCGTGGCCTACCACTTCCACGAACCGCTGGGTGTGGTCGGC
CAGATCATCCCCTGGAACTTCCCGATCCTGATGGCGACCTGGAAGCTGGCGCCCGCCCTGGCCGCGGGCAACGCCGTCGT
CCTCAAACCGGCCGAGCAGACACCGGCGTCGATCCTCTACCTGATGTCGTTGATCGCCGACCTGCTCCCGGCCGGTGTGG
TCAACGTGGTCAACGGATTCGGTGTCGAGGCGGGTAAACCGCTGGCGTCGTCGAACCGGATCGCCAAGATCGCGTTCACC
GGGGAGACCACCACGGGCCGGCTGATCATGCAGTACGCCAGCCAGAACCTGATCCCGGTCACCCTCGAACTCGGCGGCAA
GAGCCCGAACATCTTCTTCTCCGATGTGATGGCCGCCAACGACGACTACCAGGACAAGGCGCTCGAGGGCTTCACGATGT
TCGCCCTCAACCAGGGTGAGGTGTGCACGTGTCCGTCGCGCAGCCTGGTCCAGGCCGACATCTACGACGAGTTCCTCGAG
TTGGCGGCGATCCGCACCAAGGCCGTCCGCCAAGGGGATCCGCTCGACACCGAGACGATGATCGGGTCGCAGGCGTCCAA
CGATCAGCTCGAAAAGGTGTTGTCCTACATCGAGATCGGCAAGGACGAGGGTGCGCGCGTGGTCACCGGCGGTGAACGCG
CCGAGTTGGGCGGCGACCTCAACGGCGGATTCTACGTACAGCCCACGATCTTCGAGGGCAAGAACTCGATGCGCGTGTTC
CAGGAGGAGATCTTCGGCCCGGTCGTCGCGGTCACCTCGTTCAAGGACTACGACGATGCGATCTCGATGGCCAACGACAC
GCTCTACGGTCTGGGCGCCGGGGTGTGGAGCCGCGACGGCAACACCGCCTACCGGGCCGGACGTGACATCAAGGCCGGCC
GGGTGTGGACGAACTGCTATCACATGTACCCCGCGCACGCGGCGTTCGGCGGCTACAAGCAGTCCGGCATCGGGCGCGAG
AACCACAAGATGATGCTCGACCACTACCAGCAGACGAAGAACCTCCTGGTGTCGTACAGCAACAAGGCGCAGGGCTTCTT
CTAG

Protein sequence :
MTVYARPGAADALMAFESRYGNFIGGEWVAPAGGEYFENLTPVTGQTFCEIPRSTEADIDKALDAAHGAATAWGKTSPGE
RAQILIKIADRLEANLESLALAESWDNGKPIRETLNADIPLAIDHFRYFAGAIRAQEGALSQIDEDTVAYHFHEPLGVVG
QIIPWNFPILMATWKLAPALAAGNAVVLKPAEQTPASILYLMSLIADLLPAGVVNVVNGFGVEAGKPLASSNRIAKIAFT
GETTTGRLIMQYASQNLIPVTLELGGKSPNIFFSDVMAANDDYQDKALEGFTMFALNQGEVCTCPSRSLVQADIYDEFLE
LAAIRTKAVRQGDPLDTETMIGSQASNDQLEKVLSYIEIGKDEGARVVTGGERAELGGDLNGGFYVQPTIFEGKNSMRVF
QEEIFGPVVAVTSFKDYDDAISMANDTLYGLGAGVWSRDGNTAYRAGRDIKAGRVWTNCYHMYPAHAAFGGYKQSGIGRE
NHKMMLDHYQQTKNLLVSYSNKAQGFF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
VC0819 NP_230467.2 aldehyde dehydrogenase Not tested VPI-1 Protein 3e-142 62
aldA AAC12273.1 aldehyde dehydrogenase Virulence VPI Protein 4e-149 60
aldA AAK20747.1 aldehyde dehydrogenase Virulence VPI Protein 4e-149 60
aldA AAK20776.1 aldehyde dehydrogenase Virulence VPI Protein 4e-149 60
aldA-1 YP_001216300.1 aldehyde dehydrogenase Not tested VPI-1 Protein 1e-148 60
ORF SG19 AAN62241.1 putative aldehyde dehydrogenase Not tested PAGI-3(SG) Protein 2e-66 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Mkms_0640 YP_936646.1 aldehyde dehydrogenase VFG0082 Protein 1e-142 62