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Name : leuS (Mkms_5478) Accession : YP_941453.1 Strain : Mycobacterium sp. KMS Genome accession: NC_008705 Putative virulence/resistance : Unknown Product : leucyl-tRNA synthetase Function : - COG functional category : J : Translation, ribosomal structure and biogenesis COG ID : COG0495 EC number : 6.1.1.4 Position : 5715271 - 5718186 bp Length : 2916 bp Strand : - Note : leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl DNA sequence : GTGTCCTCGAGGGCCGACGGACGGGCCCGAACTCGGCCGAAACGCTCCTTATACCCTGGTGAGGTGACCGAAACCCCGAC CGCCCAGCCCGACCGGGCCGCTGATGCCGACACCCCGCAGCACCGCTACACCGCTGAGCTCGCCGGGCAGATCGAGGGCG CGTGGCAGCAGACGTGGGCGGTCGAGGGCACCTTCAACGTGCCCAATCCGGTCGGTGAGCTGGCCCCGCCGGACGGCACG GTGCCCGCCGACAAGATGTTCGTCCAGGACATGTTCCCGTACCCGTCGGGGGAGGGTCTGCACGTCGGACATCCGCTGGG CTACATCGCCACCGACGTGTACGCGCGCTACTACCGGATGACGGGGCGCAACGTGTTGCACGCGTTGGGGTTCGACGCGT TCGGTCTGCCCGCCGAGCAGTACGCGGTGCAGACCGGCACCCATCCGCGGACCCGTACCGAGGCCAACATCGTCAACTTC CGCCGCCAGCTGGGCCGGCTGGGGCTCGGCCACGACACGCGACGCAGCTTCTCCACCACCGACGTCGACTTCTACACCTG GACGCAGTGGATCTTCCTGCAGATCTACAACGCCTGGTTCGACCGTGACGCGAACAGGGCGCGACCGATCGCCGAGCTGA TCGGCGAGTTCGAGTCCGGGGTCCGCACCCTCGACGACGGTAGGCCGTGGTCGGAGCTGAGCGCCGGCGAGCGCGCCGAC GTGGTCGACTCCTATCGGCTGGTCTACCGCGCCGACTCGATGGTCAACTGGTGCCCCGGGCTGGGCACCGTGCTGGCCAA CGAGGAGGTCACCGCCGACGGCCGCAGCGACCGCGGCAACTTCCCGGTGTTCCGGAAACGCCTGCGGCAGTGGATGATGC GCATCACCGCCTACTCCGACCGCCTGCTCGAAGACCTCGAGGTGCTGGACTGGCCGGACAAGGTCAAGACGATGCAGCGC AACTGGATCGGCCGCTCGACCGGCGCCAGCGTGCAGTTCGGCACGGACGCCGGCGACATCGAGGTGTTCACCACCCGTCC CGACACCCTTTTCGGCGCGACGTATCTGGTGCTGGCGCCCGAACATCCGCTCGTCGAGCAGTTGGCGGCCGAGCAGTGGC CCGACGATGTGGACGGCCGGTGGACGTTCGGTGCGACGACCCCGCGCGAGGCGGTCGCCGCCTACCGCGCGTCGATCGCC GCGAAGAGCGACCTGGAGCGCCAGGAGAACAAGACCAAGACCGGCGCGTTCCTGGGCGCGTACGCCACGAATCCCGCCAA CGGACAACAGGTTCCGATCTTCATCGCCGACTACGTGCTGATCGGCTACGGAACCGGCGCGATCATGGCGGTGCCCGGCC ACGACCAGCGGGACTGGGAGTTCGCGCACGAGTTCGGGCTGCCGGTCGTCGAGGTGATCTCCGGCGGAGACATCAGCGAG GCGGCCTACGCCGGTGACGGCCTGCTGGTGAACTCCGATTACCTCGACGGGCTGGACGTGGCGGCGGCGAAGGCGGCGAT CACCGATCGGCTGGTCGCCGACGGCCGCGGCCGGGCGCGCGTCGAATACAAGCTGCGCGACTGGCTTTTCGCGCGCCAGC GGTACTGGGGTGAGCCGTTCCCGATCGTCTACGACAGCGACGGTCGTCCGCATCCGCTGCCGGAGTCCGCACTGCCGGTG GAGCTTCCGGACGTCCCGGACTACTCGCCGGTGCTGTTCGACCCGGATGACGCGGACAGCGAACCGAATCCGCCGTTGAA CAAGGCGACTGATTGGGTGCACGTCGAACTCGATCTCGGTGACGGTCTGCAGACCTACACCCGCGACACCAACGTGATGC CGCAGTGGGCGGGCAGCTCCTGGTACGAGCTGCGCTACACCGATCCGCTGAACAAAGAAGCGTTGTGCGCCAAGGAGAAC GAGGCCTACTGGATGGGGCCGCAGCCGGCCGAGCACGGCCCCGACGACCCCGGCGGCGTGGACCTCTACGTCGGCGGTGT CGAGCACGCCGTGCTGCACCTGCTGTACTCGCGGTTCTGGCACAAGGTGCTCTACGACCTGGGCCACGTCAGCTCGCGGG AGCCCTACCGGCGCCTGGTCAACCAGGGCTACATCCAGGCGTTCGCCTACACCGATTCGCGGGGGTCGTACGTGCCGGCC GCCGAGGTCGTCGAGCGGGACGGGAAGTTCTGGTTCGAAGGTGCGGAGGTCTTCCAGGAGTTCGGCAAGATCGGCAAGAG CCTGAAGAACTCGGTGTCGCCGGACGAGATCTGCGACAACTACGGCGCCGACACGCTGCGGGTGTACGAGATGTCGATGG GTCCGCTCGAGGCGTCGCGACCGTGGGCCACCAAGGACGTCGTCGGCGCGCACCGGTTCCTGCAGCGGGTGTGGCGACTG GTGGTCGACGAGCAGAGCGGTGCGGTGCGGGTGGCCAATCACGAGGCGCTCGACACCGACACCCTGCGCGCGCTGCACCG CACCGTCGCGGGGGTGTCGGAAGACTATGCGGCGCTTCGCAACAACACCGCGGCGGCCAAGCTGATCGAGTACACCAACC ACCTGACGAAGGAGGGGGTGACGGCTCGGGCGGCCATCGAACCGCTGGTGTTGATGGTCGCGCCGCTGGCGCCGCATCTG GCCGAGGAACTGTGGCGGCGGCTGGGGCACGACACGTCGCTGGCGCACGGTCCGTTCCCGGTGGCCGACCCGCAGTATCT GGTGACCGACACCGTCGAGTACCCGGTGCAGGTCAACGGGAAGGTGCGCAGCCGGATCACGGTCGACGCCGATGCCGGCA AGGACACGCTCGAGGCGGCGGCGCTGGCCGACGAGAAGGTGCAGGCGTTCCTCAACGGGGCGACGCCGAAGAAGGTGATC GTCGTCCCGGGCCGCCTGGTCAACCTCGTCGTGTAG Protein sequence : MSSRADGRARTRPKRSLYPGEVTETPTAQPDRAADADTPQHRYTAELAGQIEGAWQQTWAVEGTFNVPNPVGELAPPDGT VPADKMFVQDMFPYPSGEGLHVGHPLGYIATDVYARYYRMTGRNVLHALGFDAFGLPAEQYAVQTGTHPRTRTEANIVNF RRQLGRLGLGHDTRRSFSTTDVDFYTWTQWIFLQIYNAWFDRDANRARPIAELIGEFESGVRTLDDGRPWSELSAGERAD VVDSYRLVYRADSMVNWCPGLGTVLANEEVTADGRSDRGNFPVFRKRLRQWMMRITAYSDRLLEDLEVLDWPDKVKTMQR NWIGRSTGASVQFGTDAGDIEVFTTRPDTLFGATYLVLAPEHPLVEQLAAEQWPDDVDGRWTFGATTPREAVAAYRASIA AKSDLERQENKTKTGAFLGAYATNPANGQQVPIFIADYVLIGYGTGAIMAVPGHDQRDWEFAHEFGLPVVEVISGGDISE AAYAGDGLLVNSDYLDGLDVAAAKAAITDRLVADGRGRARVEYKLRDWLFARQRYWGEPFPIVYDSDGRPHPLPESALPV ELPDVPDYSPVLFDPDDADSEPNPPLNKATDWVHVELDLGDGLQTYTRDTNVMPQWAGSSWYELRYTDPLNKEALCAKEN EAYWMGPQPAEHGPDDPGGVDLYVGGVEHAVLHLLYSRFWHKVLYDLGHVSSREPYRRLVNQGYIQAFAYTDSRGSYVPA AEVVERDGKFWFEGAEVFQEFGKIGKSLKNSVSPDEICDNYGADTLRVYEMSMGPLEASRPWATKDVVGAHRFLQRVWRL VVDEQSGAVRVANHEALDTDTLRALHRTVAGVSEDYAALRNNTAAAKLIEYTNHLTKEGVTARAAIEPLVLMVAPLAPHL AEELWRRLGHDTSLAHGPFPVADPQYLVTDTVEYPVQVNGKVRSRITVDADAGKDTLEAAALADEKVQAFLNGATPKKVI VVPGRLVNLVV |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| leuS | YP_281511.2 | leucyl-tRNA synthetase | Not tested | Not named | Protein | 7e-157 | 49 |
