Gene Information

Name : Mkms_4221 (Mkms_4221)
Accession : YP_940203.1
Strain : Mycobacterium sp. KMS
Genome accession: NC_008705
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.1
Position : 4446994 - 4448172 bp
Length : 1179 bp
Strand : -
Note : catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine

DNA sequence :
ATGACTGAACAGCGCAGCGCCCACGGACCCGCCCACGGACTCGCCACTGGACTCGCCACGAAGGCCATCCACGCCGGGTA
CGCCCCCGACCCCCGCACCGGTGCGGTCAACACGCCGATCTACGCCAGCTCGACCTTCGCCCAGGACGGTGTCGGAGGGC
TGCGGGGCGGCTTCGAGTACGCCCGCACCGGCAACCCGACGCGGCAGTCCCTGGAGTCGGCGCTGGCCGCGGTGGAGGAA
GCCGGGTACGGCCGGGCCTTCGCCTCCGGGATGGCCGCCACCGACTGTGCGTTGCGCGCGGTGCTGCGCCCCGGTGACCA
TCTCGTCATCCCGGACGACGCCTACGGCGGCACGTTCCGGCTGATCGACAAGGTGTTCTCCCAGTGGGGCATCAGCTACA
CGGCGGTCGCGCTGTCGGACCTCGACGCCGTCCGGGCGGCGATCACCCCGCAGACCAAGATGATCTGGGTCGAGACGCCG
ACCAACCCGCTGCTGTCGATCGCCGACATCGCCGGTATCGCAGGCATCGCGGCCGAATCGGGGCTGAAGGTGTTGGTGGA
CAACACCTTTGCCTCGCCCGCGTTACAGCAGCCGTTGCTGCTCGGCGCGGACATCGTGTTGCACTCCACCACGAAGTACA
TCGGCGGACACTCCGACGTGGTCGGCGGCGCGCTGCTGACCAACGACGAGGAACTCGACACGGCGTTCGCCTTCCTGCAG
AACGGATCGGGCGCCGTCCCAGGACCGTTCGACGCCTACCTCACCCTGCGCGGACTCAAGACGCTGGTGGTGCGGATGCA
GCGACACAGCGAGAACGCTGCGGCGGTCGCCGAATTCCTCGACGGCCACCCGGCGATCGACACGGTGCTCTATCCCGGTC
TGCCCAGCCATCCCGGCCACGACGTGGCCGCCAAGCAGATGAGCGGGTTCGGCGGCATGGTGTCGGTGCGGCTACACGGC
GGGCCCAAGGCGGCTCGCGAATTCTGCGCCCGCACAGGCATTTTCATCCTCGCCGAATCGCTGGGCGGGGTGGAGTCGCT
GATCGAGCATCCGGGTGCGATGACGCACGCGTCCACCGCCGGATCCCAACTCGAGGTGCCCGAGGATCTGGTGCGGCTGT
CGGTCGGCATCGAGGACCGCGCGGATCTGATCGCCGACCTGGAGCAGGCGCTAGCCTAA

Protein sequence :
MTEQRSAHGPAHGLATGLATKAIHAGYAPDPRTGAVNTPIYASSTFAQDGVGGLRGGFEYARTGNPTRQSLESALAAVEE
AGYGRAFASGMAATDCALRAVLRPGDHLVIPDDAYGGTFRLIDKVFSQWGISYTAVALSDLDAVRAAITPQTKMIWVETP
TNPLLSIADIAGIAGIAAESGLKVLVDNTFASPALQQPLLLGADIVLHSTTKYIGGHSDVVGGALLTNDEELDTAFAFLQ
NGSGAVPGPFDAYLTLRGLKTLVVRMQRHSENAAAVAEFLDGHPAIDTVLYPGLPSHPGHDVAAKQMSGFGGMVSVRLHG
GPKAAREFCARTGIFILAESLGGVESLIEHPGAMTHASTAGSQLEVPEDLVRLSVGIEDRADLIADLEQALA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-70 48
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 3e-69 47
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 1e-51 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Mkms_4221 YP_940203.1 cystathionine gamma-synthase BAC0207 Protein 7e-58 44