Gene Information

Name : Mkms_3534 (Mkms_3534)
Accession : YP_939518.1
Strain : Mycobacterium sp. KMS
Genome accession: NC_008705
Putative virulence/resistance : Virulence
Product : AMP-dependent synthetase and ligase
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : -
Position : 3721273 - 3722922 bp
Length : 1650 bp
Strand : +
Note : PFAM: AMP-dependent synthetase and ligase; KEGG: mmc:Mmcs_3471 AMP-dependent synthetase and ligase

DNA sequence : 
ATGAGCACCGGATTCCAGCATGTGCACAGCGACCTGACCGATGGCTTCGTCCCATTCCCCGAAGACCGCGCCGAGCAGTA
CCGGCGGGCCGGGTACTGGACCGGGCGGCCCCTCGAGTCCCTTCTCCTTGACGCGGCACACCGACGGCCCGATCACCCGG
CCGTCGTCGACGTCGACGGATCCCTCACGTTCGCGGAGCTGACCGCGCGCGCCGACACCGTCGCCGCGGCGCTGGCCGGA
CTCGGGATCCGTCCTGGTGACCGGGTGCTGCTGCAACTACCCAACTCCGTGCGTTTCGCCGTCGCGTTCTTCGGTCTGCT
GCGGGCGGGCGCGGTGCCGGTGATGTGCCTGCCCGGCCACCGCACCGCCGAGCTGGGACACTTCGCCGACGTCAGCGGCG
CGGTGGCGCTGATCGTGCCCGACGAGGTCGGCGGCTTCGACTACCGCGAGATGGCCGCCCAGTTGGTGGCGGACCGGCCC
ACGCTGCGGCACGTGCTCGTCGACGGTGACCCGGGACCGTTCCTATCGTGGGCGGCACTGATCGACAGCGGCGGCGTGGC
ACCGGAGATCGGACCCGTCGACACCTCGCTGCCTGCCCTGCTGCTGGTCTCCGGCGGAACGACCGGACTGCCCAAGCTGA
TCCCCCGCACCCACGACGACTACGTCTACACCGCGGTGTCGAGCGCGCAGGCGTGCCACTTCACCCCCGACGACGTCTAC
CTGGTGGCGTTGCCGGCCGGCCACAACTTCCCGTTGGCGTGCCCCGGCATGCTGGGGGCAATGACCGTGGGGGCGACGAC
GGTGTTCACCGCCGATCCCAGCCCGGAGGAGGCGTTCGCGCTCATCGACAAACACCAGGTGACCGTCACCGGGCTGGTCA
ACGCGCTGGGCAAGCTGTGGGCGCAGGCGTGCGACTGGGAACCGGTGCTGCCGACGTCGCTGCGCCTGGTGCAGGTGGGC
GGTTCGCGGATGAGCCCGGAGGAGGCGCGGTTCATCCTCGATCGCCTGACCCCCGGGCTGTCCCAGATCTTCGGAATGGC
CGAGGGCATGCTGAATTTCACGCGGCCGGGAGATCCGCTCGACGTCGTGGTGCACACCCAGGGCAGGCCGGTCTCCCCGC
ACGACGAGATGCGGGTGGTCGACGAGTCCGGTGTCGAGGTCGCACCGGGTGAAGAGGGCGAACTGCTGGTGCGCGGTCCC
AACACACTCAACGGGTACTACCGGGCCGACGAGGCCAACGCCCGGTGCTTCAGCCCGGACGGCTTCTACCGCACCGGGGA
CCGGGTGCGGATCTTCGCCGACGGCCCGCTGGCCGGCAACGTCGAGGTGACCGGCCGGATCAAGGACGTCATCCACCGCG
GCGGTGAGACGGTTTCGGCGACCGACCTCGAGGACCATCTGCTGACCCACCCCGCGATCTATGCGGCGGCCGCCGTCGCG
CTACCCGACGACTATCTCGGTGAGAAGATCTGCGCCGCAGTGGTGTTCCGCGGCAAGCAGCTCACGCTCGCCGAACTCAA
CGCATTCCTCGACGAACGCGGGGCGTCCACTCACGCCCGGCCCGACGTGCTGGCTGCGATGCCGTCGCTGCCGCTGACCG
CGGTCGGCAAGGTCGACAAGAAGAAGCTCGTCGCCCAGCTGACGGGGTGA

Protein sequence : 
MSTGFQHVHSDLTDGFVPFPEDRAEQYRRAGYWTGRPLESLLLDAAHRRPDHPAVVDVDGSLTFAELTARADTVAAALAG
LGIRPGDRVLLQLPNSVRFAVAFFGLLRAGAVPVMCLPGHRTAELGHFADVSGAVALIVPDEVGGFDYREMAAQLVADRP
TLRHVLVDGDPGPFLSWAALIDSGGVAPEIGPVDTSLPALLLVSGGTTGLPKLIPRTHDDYVYTAVSSAQACHFTPDDVY
LVALPAGHNFPLACPGMLGAMTVGATTVFTADPSPEEAFALIDKHQVTVTGLVNALGKLWAQACDWEPVLPTSLRLVQVG
GSRMSPEEARFILDRLTPGLSQIFGMAEGMLNFTRPGDPLDVVVHTQGRPVSPHDEMRVVDESGVEVAPGEEGELLVRGP
NTLNGYYRADEANARCFSPDGFYRTGDRVRIFADGPLAGNVEVTGRIKDVIHRGGETVSATDLEDHLLTHPAIYAAAAVA
LPDDYLGEKICAAVVFRGKQLTLAELNAFLDERGASTHARPDVLAAMPSLPLTAVGKVDKKKLVAQLTG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 1e-91 44
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-91 44
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-91 44
ybtE CAA21394.1 - Virulence HPI Protein 1e-91 44
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 2e-91 44
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 1e-91 44
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 2e-91 44
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 2e-91 44
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-91 44

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Mkms_3534 YP_939518.1 AMP-dependent synthetase and ligase VFG1817 Protein 3e-172 67
Mkms_3534 YP_939518.1 AMP-dependent synthetase and ligase VFG0168 Protein 1e-85 42
Mkms_3534 YP_939518.1 AMP-dependent synthetase and ligase VFG0932 Protein 2e-80 41