Gene Information

Name : guaA (azo1581)
Accession : YP_933085.1
Strain : Azoarcus sp. BH72
Genome accession: NC_008702
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1738436 - 1740001 bp
Length : 1566 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGTCCCACCAGAAAATCCTCATTCTCGATTTCGGCTCCCAGGTTTCGCAGCTGATTGCACGGCGCGTGCGCGAACAACA
CGTGTATTGCGAACTGCACCCCTACGACGTGTCCGAAGCCTTCATCCGGGACTTCAAGCCGCAGGGCATCATCCTTTCCG
GTGGTCCGAATTCGGTGTACGAGGCGGTGGACTGGCGTGCGCCGCAGGTGGTCTTCGAACTCGGCGTGCCGGTGCTCGGT
ATCTGCTACGGCATGCAGACCATGGCCGAGCAACTCGGCGGCAAGGTCGAAAGCTCCGCCAAGCGCGAGTTCGGCTATGC
AGAACTGCGCGCCCGTGGCCATTCCAAGCTGTTCCAGGGCATCGAGGACCGGACCAACGCCGAAGGCCACGGCCTGCTCG
ACGTGTGGATGAGCCACGGCGACAAGGTCACTGAGCTGCCCGCCGGCTTCAAGGTGATCGGCAGCAACGAATCCTGCCCG
GTGGCGGCGATGGCGGACGAGGAGCGCGGCTTCTACGGCGTGCAGTTCCACCCGGAAGTCACCCACACGATCAAGGGCAA
GGAAATGCTCGCCCGCTTCGTGCACGAGATCTGCGGCTGCGGCAATGACTGGAACATGCCGGACTACATTTCGGAAGCGG
TCGAGAAGATCCGCGCCCAGGTTGGCGACGAGGAAGTCATCCTCGGCCTGTCGGGCGGGGTCGATTCCTCGGTGGCGGCG
GCGCTGATCCACCGTGCCATTGGCGACCAGCTCACCTGCGTGTTCGTCGACAACGGCTTGCTGCGCCTCAACGAAGGCGC
GCAGGTGATGGAAACCTTCAACCGCTCGCTCGGCGTCAAGGTCATCCACGTCGATGCCACCGAGCAGTTCATGGGCCATC
TGAAAGGCGTTTCGGACCCCGAGCAGAAACGCAAGATCATCGGCCGCGAATTCGTCGAGGTGTTCCAGGCCGAAGCGGCC
AAGCTGCCCAAGGCGCGCTGGCTGGCGCAGGGCACGATCTACCCGGACGTGATCGAGTCCGCTGGCGCCAAGACCGGCAA
GGCGCACGCGATCAAGAGCCACCACAACGTGGGCGGCCTGCCCGAAACGCTCAACCTCAAGCTGCTTGAGCCGCTGCGCG
ACCTCTTCAAGGACGAAGTGCGCGAACTCGGCGTCGCCCTCGGCCTGCCGCACGACATGGTCTATCGCCATCCCTTCCCC
GGCCCCGGCCTGGGCGTGCGCATCCTCGGCGAGGTCAAGAAGGAATTCGCCGACCTGCTGCGTCGCGCCGATGCGATCTT
CATCGACGAACTGCGCGCCGCGGACTGGTACGACAAGACCAGTCAGGCTTTTGCGGTCTTCCTGCCGGTAAAGAGCGTGG
GCGTAATGGGCGACGGCCGCACCTACGAATACGTGGTGGCGCTGCGCGCCGTGCAGACCCAGGACTTCATGACGGCGCAC
TGGGCGGAGCTGCCCCACAGCCTGCTGGGCAAGGTGAGTAACCGCATCATCAACGAAGTCCGCGGCATCAACCGGGTGGT
GTACGACATCTCGGGCAAACCGCCAGCGACAATCGAGTGGGAGTGA

Protein sequence :
MSHQKILILDFGSQVSQLIARRVREQHVYCELHPYDVSEAFIRDFKPQGIILSGGPNSVYEAVDWRAPQVVFELGVPVLG
ICYGMQTMAEQLGGKVESSAKREFGYAELRARGHSKLFQGIEDRTNAEGHGLLDVWMSHGDKVTELPAGFKVIGSNESCP
VAAMADEERGFYGVQFHPEVTHTIKGKEMLARFVHEICGCGNDWNMPDYISEAVEKIRAQVGDEEVILGLSGGVDSSVAA
ALIHRAIGDQLTCVFVDNGLLRLNEGAQVMETFNRSLGVKVIHVDATEQFMGHLKGVSDPEQKRKIIGREFVEVFQAEAA
KLPKARWLAQGTIYPDVIESAGAKTGKAHAIKSHHNVGGLPETLNLKLLEPLRDLFKDEVRELGVALGLPHDMVYRHPFP
GPGLGVRILGEVKKEFADLLRRADAIFIDELRAADWYDKTSQAFAVFLPVKSVGVMGDGRTYEYVVALRAVQTQDFMTAH
WAELPHSLLGKVSNRIINEVRGINRVVYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 5e-130 53
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 4e-130 53
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 4e-130 53
guaA NP_938969.1 GMP synthase Not tested Not named Protein 4e-113 49