Gene Information

Name : guaA (Pisl_0600)
Accession : YP_930121.1
Strain : Pyrobaculum islandicum DSM 4184
Genome accession: NC_008701
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : -
Position : 549242 - 550759 bp
Length : 1518 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
GTGGAGAGAATAGTAGTTGTAAATTTCGGCGGGCAATATGCCCATTTAATTGCCAGACGTCTCAGAGAAAGGGGGGTGTA
TACGGAGATTGTTACGCCTGAAGACGCCGTTGAAATAGCCAAAGCGCCAGATGTAAAAGCAATAATTCTCTCTGGAGGCC
CTAGTTCTGTTTATCAAGAAGGTGCGCCTGACGTACCAGATGAGTTATTTGCTATTGGTAAGCCTATACTTGGCATATGC
TATGGACACCAATTGATTGCAAAAAAGTTGGGGGGTTTGGTAAGGCGGGGTAAGGGTGAATATGGTAAGACGTTGGTAAG
GGTGTTGGTAAACGACCATATTTTCGACACATGGGAAAGCGAAGAGATAGTTTGGATGAGCCATAGCGACTATGTAGCGC
AACCTCCAGAAGGGTTTACCATTTTGGCAGTAAGCGAGAATGGGTACGTGGCTGCTATGAAGAAGGATTATATCTACGGT
GTACAATTCCACCCAGAGGTTGTCCATACGCCAAAAGGCGGTGTATTGTTGGAGAATTTTGCTAGGAAAATAGCCGGGGT
AAAGCATGTGTGGAAACCAGAGGATCAGATAGGCAAACTCATTGAGGAGATTAGAAAGGAGGTAAAAGATGGCGATATAA
TTATCGGCGTAAGCGGTGGCGTTGATAGTACTGTAGTTGCTGTACTTGTACATATGGCAGTTGGAGAGAGGGCAAAGGCT
GTGTTTATAGACCATGGGTTGTTTAGAGAGGGAGAGCCTGAGCAAGTTGTGAAACTATTAAATTCGCTTGGCATAAAAGT
TTACTACGTTGACGCGCGTGAGCGATTTCTAAAGCGGCTAGAGGGCGTCTCTGACTGTGAAGAAAAACGTAGAATAATAG
GGGAGACATTTGCAGAAGTATTTACAGAGACTTTATCCAAGTTCCCAGAGGTGAAATATTTAGCTCAAGGCACTCTGTAC
CCTGACGTTATAGAAAGCGGAGCGGTAAAGGGAGCAGATAAAATAAAGAGTCATCATAACGTAGGCGGTTTACCAAGGTG
GTTTAACTTAAAACTTATCGAGCCGCTTCGCGAGTTCTACAAAGATGAAGTAAGAAAATTGGCAAGGGCCCTAGGCTTGC
CAGACGAGGTGGTATACAGACACCCATTTCCAGGCCCTGGTTTAGCAGTACGTATAATCGGGCCGTTTACCAGAGAGAAG
TTGGAAATTGTGAGAAAGGCTACTAAAATTATAGAAGAGGAGTTGGAGAAAGGAGGTATTTTGAGAAAGGTGTGGCAAGC
TTTTGCAGTAGTTGGCGATGACAAATGGGTGGGTGTGAAGGGTGATAGACGTACTGTCGGTTATATTGTAACTATAAGGG
TTGTAGAGAGTGAAGACGCGATGACGGCAGATTGGTCGCGTTTACCCTATGAAGTCATAGAGAGAATCTCAACACGTATA
ACTTCCGAAATCCCCCAAGTGACTATGGTTACATATGCCGTCACTACAAAACCGCCGTCAACTATAGAACCCTGTTAA

Protein sequence :
MERIVVVNFGGQYAHLIARRLRERGVYTEIVTPEDAVEIAKAPDVKAIILSGGPSSVYQEGAPDVPDELFAIGKPILGIC
YGHQLIAKKLGGLVRRGKGEYGKTLVRVLVNDHIFDTWESEEIVWMSHSDYVAQPPEGFTILAVSENGYVAAMKKDYIYG
VQFHPEVVHTPKGGVLLENFARKIAGVKHVWKPEDQIGKLIEEIRKEVKDGDIIIGVSGGVDSTVVAVLVHMAVGERAKA
VFIDHGLFREGEPEQVVKLLNSLGIKVYYVDARERFLKRLEGVSDCEEKRRIIGETFAEVFTETLSKFPEVKYLAQGTLY
PDVIESGAVKGADKIKSHHNVGGLPRWFNLKLIEPLREFYKDEVRKLARALGLPDEVVYRHPFPGPGLAVRIIGPFTREK
LEIVRKATKIIEEELEKGGILRKVWQAFAVVGDDKWVGVKGDRRTVGYIVTIRVVESEDAMTADWSRLPYEVIERISTRI
TSEIPQVTMVTYAVTTKPPSTIEPC

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-97 49
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-97 49
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 4e-97 48
guaA NP_938969.1 GMP synthase Not tested Not named Protein 9e-96 47