Gene Information

Name : guaA (Noca_3631)
Accession : YP_924818.1
Strain : Nocardioides sp. JS614
Genome accession: NC_008699
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 3849134 - 3850717 bp
Length : 1584 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACGCAGCCCGCGGAGCACGATCTGGTCCTGGTGGTCGACTTCGGGGCGCAGTACGCCCAGCTGATCGCCCGGCGGGT
CCGCGAGGCGCGGGTCTACTCCGAGATCGTGCCGCACACGACCCCGGTGGCCGAGATCCTGGCCCGCGAGCCGAAGGCGA
TCATCCTCTCCGGCGGCCCGTCCTCGGTCTACGAGCCCGACGCCCCGAGCATCGACCCCGCGATCTTCACCTCCGGCACC
CCGGTGTTCGGGATGTGCTACGGCTTCCAGCTGATGGCCCAGGGCCTCGGGGGCGAGGTGGCCCACACCGGCGCCCGGGA
GTACGGGCGTACGGCGGTCGCCGTGGCCCGACCCGGGACGCTGCTGGCGGACATCCCCGCGCACCACACCGTGTGGATGT
CGCACGGCGACTCGGTGGCGGCCGCCCCGTCCGGCTTCGACGTGCTGGCCTCGACGGCCACGACGCCGGTGGCGGCGTTC
GAGGACGTCGACCGCGGCCTGGCCGGCGTCCAGTGGCACCCCGAGGTGCTGCACACCGAGCACGGCCAGAAGGTGCTCGA
GCACTTCCTGGTCCAGATCGCCCACTGCCGCCAGACCTGGACCATGGTCAACATCGTCGAGGAGCAGATCGAGGCCATCC
GCGCGCAGATCGGCGATCGCGGCCAGGCGATCTGCGGGCTGTCCGGCGGCGTCGACTCCGCGGTCGCGGCCGCGATCGTG
CAGCGGGCGATCGGCGACCGGCTCACCTGTGTGTACGTCGACCACGGGCTGATGCGCCAGGGCGAGACCGAGCAGGTCGA
GCGCGACTTCGTGGCCGCGACCGGCGTCGACCTCAAGGTCGTCGACGCCGAGAAGCAGTTCCTCGACGCACTCGCGGGCG
TCACCGACCCCGAGGAGAAGCGCAAGATCATCGGCCGCGAGTTCATCCGGGTCTTCGAGGCCGCGGAGGCGGACATCCTC
GGCGGGAGTCTGCCGGACGATGGGGGGAGCAAGGTCGCGTTCCTCGTCCAGGGCACGCTCTACCCCGACGTGGTCGAGTC
CGGCGGGGGAGCGGGGACCTCCAACATCAAGTCACACCACAACGTCGGCGGCCTGCCCGACGACCTCGAGTTCGAGCTGG
TCGAGCCGCTGCGCACCCTGTTCAAGGACGAGGTCCGGCTGGTCGGCGAGCAGCTCGGCCTGCCGGCCGAGATCGTGTGG
CGCCAGCCGTTCCCGGGCCCCGGGCTCGGCATCCGGATCATCGGCGAGGTCACCCGCGAGCGGCTCGACATCCTCCGCGA
GGCCGACGCCATCGCCCGGGAGGAGCTCACCCGCGCCGGCCTGGACCGCGACATCTGGCAGTTCCCCGTCGTGCTCCTCG
CCGACGTCCGCTCGGTCGGCGTCCAGGGTGACCACCGCACCTACGGACACCCCGTCGTGCTCCGTCCGGTCACCTCCGAG
GACGCGATGACCGCCGACTGGGCGCGGCTGCCGTACGACGTGCTCGAGCGGATCTCGACCCGGATCACCAACGAGGTGCG
GGAGATCAACCGGGTGACGGTCGACATCACCTCCAAGCCCCCGGGCACCATCGAGTGGGAGTGA

Protein sequence :
MTQPAEHDLVLVVDFGAQYAQLIARRVREARVYSEIVPHTTPVAEILAREPKAIILSGGPSSVYEPDAPSIDPAIFTSGT
PVFGMCYGFQLMAQGLGGEVAHTGAREYGRTAVAVARPGTLLADIPAHHTVWMSHGDSVAAAPSGFDVLASTATTPVAAF
EDVDRGLAGVQWHPEVLHTEHGQKVLEHFLVQIAHCRQTWTMVNIVEEQIEAIRAQIGDRGQAICGLSGGVDSAVAAAIV
QRAIGDRLTCVYVDHGLMRQGETEQVERDFVAATGVDLKVVDAEKQFLDALAGVTDPEEKRKIIGREFIRVFEAAEADIL
GGSLPDDGGSKVAFLVQGTLYPDVVESGGGAGTSNIKSHHNVGGLPDDLEFELVEPLRTLFKDEVRLVGEQLGLPAEIVW
RQPFPGPGLGIRIIGEVTRERLDILREADAIAREELTRAGLDRDIWQFPVVLLADVRSVGVQGDHRTYGHPVVLRPVTSE
DAMTADWARLPYDVLERISTRITNEVREINRVTVDITSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-177 71
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-142 53
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-142 52
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-142 52