Gene Information

Name : guaA (Pden_3696)
Accession : YP_917459.1
Strain :
Genome accession: NC_008687
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 844552 - 846111 bp
Length : 1560 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACCCAGCATCAGCGCCTTCTCATCATCGATTTCGGCTCCCAGGTCACGCAGTTGATTGCGCGCCGCCTGCGCGAGTT
GAACGTCTATTGCGAAATCCACCCGTTCAACGCGGTCGACGACGCCTTCCTGAAAGACTTCGCCCCGCAGGCCGTGATCC
TGTCGGGCGGTCCCGCCTCGGTCACCCAGGCGGATTCGCCGCGCGCGCCGCAGAGCCTCTTCGACATGCAGGTGCCGGTC
TTCGGCATCTGCTATGGCCAGCAGGTGATGATGGAGCAGTTGGGCGGCCGCGTCGAATCGGGCCATCACGCCGAATACGG
CCGCGCCTTCATCGCACCCGCCGATGGGCACAAGGGCGATGGCATCTTCGCCGGCCTGTTCGATACCGGCCGCGAGGAAG
TCTGGATGAGCCATGGCGACCGCGTCACCCGGCTTGCGCCGGGCTTCGAGGTGATCGGCACCTCGCCCAATGCCCCCTTC
GCCATGATCGCGGACGAGGCACGCAAGTTCTTTGCCGTGCAATTCCATCCCGAGGTCCATCACACCCCGAACGGCCGCCG
GATGCTGGAGAATTTCGTCCGCATGGCGGGCTTTGCCGGCGACTGGACCATGGCATCCTATCGCCAGGAGGCGATCCGCA
AGATTCGCGAGCAGGTCGGAAGCAAGCGGGTGATCTGCGGGCTGTCGGGCGGCGTCGACAGTTCGGTCGCCGCCGTGCTG
ATCCACGAGGCGATCGGCGACCAGTTGACCTGCGTCTTCGTCGATCACGGGCTTTTGCGGCTGAACGAGGCCGAGGAAGT
CGTGACCATGTTCCGCGACAACTACAACATCCCGCTGATCCATGCCGACGAGAGCGAGTTGTTCCTGTCGGCGCTGGAGG
GCGTCAGCGACCCCGAGGTCAAGCGCAAGACCATCGGCAAGCTCTTCATCGACGTGTTCCAGAAATACGCGAGCGAAATC
GAGGGCGCGGAATTCCTGGCCCAGGGTACGCTTTACCCGGACGTGATCGAATCGGTCAGCTTCTCGGGCGGCCCCTCGGT
CACGATCAAGAGCCACCACAATGTCGGCGGCCTGCCCGAGAAGATGGGGCTGAAGCTGGTCGAACCGCTGCGCGAGCTTT
TCAAGGACGAGGTCCGCGCCCTGGGCCGCGAGCTTGGCCTGCCCGAGAAATTCATCGGCCGCCATCCCTTTCCCGGCCCC
GGCCTTGCCATCCGCTGCCCGGGCGAGATCACCCGCGACAAGCTGGAGATCCTGCGCAAGGCCGATGCGGTCTTCATCGA
CCAGATCCGCAAGCACGGGCTTTATGACGAGATCTGGCAGGCCTTCGTCGCCATCCTGCCGGTGCGCACCGTGGGCGTGA
TGGGCGACGGGCGCACCTACGATTATGCCTGCGCGTTGCGCGCCGTGACCTCGGTCGATGGCATGACGGCGGATTACTAT
CCCTTCAGCCACGAGTTCCTGGGCGAGACCGCGACGCGGATCATCAACGAGGTCAAGGGCATCAACCGCTGCACCTATGA
CATCACCTCGAAGCCGCCGGGCACGATCGAGTGGGAATGA

Protein sequence :
MTQHQRLLIIDFGSQVTQLIARRLRELNVYCEIHPFNAVDDAFLKDFAPQAVILSGGPASVTQADSPRAPQSLFDMQVPV
FGICYGQQVMMEQLGGRVESGHHAEYGRAFIAPADGHKGDGIFAGLFDTGREEVWMSHGDRVTRLAPGFEVIGTSPNAPF
AMIADEARKFFAVQFHPEVHHTPNGRRMLENFVRMAGFAGDWTMASYRQEAIRKIREQVGSKRVICGLSGGVDSSVAAVL
IHEAIGDQLTCVFVDHGLLRLNEAEEVVTMFRDNYNIPLIHADESELFLSALEGVSDPEVKRKTIGKLFIDVFQKYASEI
EGAEFLAQGTLYPDVIESVSFSGGPSVTIKSHHNVGGLPEKMGLKLVEPLRELFKDEVRALGRELGLPEKFIGRHPFPGP
GLAIRCPGEITRDKLEILRKADAVFIDQIRKHGLYDEIWQAFVAILPVRTVGVMGDGRTYDYACALRAVTSVDGMTADYY
PFSHEFLGETATRIINEVKGINRCTYDITSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-129 52
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-129 52
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-129 52
guaA NP_938969.1 GMP synthase Not tested Not named Protein 3e-113 49