|
Name : ureC (Pden_1208) Accession : YP_915009.1 Strain : Genome accession: NC_008686 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : - Position : 1180388 - 1182076 bp Length : 1689 bp Strand : - Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGGGTCAGACGCTCTCGCGCGCCGATTACGCGGCGCTTTACGGCCCCACCACCGGCGACCGCATCCGGCTGGCCGATAC CGAACTGCTGATCGAGGTCGAGCGCGACCTGACCATCCCCGGCGAGGAGGTCCGCTTCGGCGGCGGCAAGGTCGTCCGCG ACGGCATGGGCCAGTCGCAAGTGACGCGCGAGGCCGGGGCGATGGATACGGTCATCACCGGCGCCGTGGTCTTCGACCAC CAAGGCATCACCAAGGCCGATGTCGGGCTGCGGGACGGGCGCATCGCCGGGATCGGCAAGGCCGGCAATCCCGACACCCA GCCCGGCGTGACCCTGATCATCGGGCCGGGGACCGAGATCATCGCGGGCGAGGGCCGCATCCTCACCCCCGGCGGCATGG ACTGCCATATCCACTTCATCTGCCCGCAACAGGTGGACCACGCGCTGCATTCCGGCGTCACCACGCTGCTGGGCGGCGGC ACCGGCCCCGCGCATGGCACGCTGGCCACCACCTGCACGCCGGGGCCCTGGCATATCGCCCGGATGCTGGAAGCCTGCGC CGAACTGCCGGTCAATATCGGCATCGCGGGCAAGGGCAACGCCTCGCTGCCCGCCGCGCTCGAGGAACAGGTCCGCGCGG GCGCCTGCGCGCTGAAGCTGCACGAGGACTGGGGCACCACCCCAGCCGCCATCGACTGCTGCCTGACCGTGGCCGATGCG ATGGACGTGCAGGTGATGATCCATACGGACACGCTGAACGAATCCGGCTTCGTCGAGGATACGATGGCCGCCATCGCCGG CCGCACCATCCACGCCTATCACACCGAGGGCGCGGGCGGCGGCCATGCCCCCGACATCATCCGCATGGTGGGGATGGGCA ACGTGCTGCCCTCATCGACCAACCCGACGCGGCCCTATACCGGCAACACCATCGAAGAGCATCTGGACATGCTGATGGTC TGCCATCATCTCGACCGCCGGGTGCCCGAGGACGTGGCCTTCGCGGAATCCCGCATCCGGCGCGAAACCATCGCGGCCGA GGACATCCTGCACGATCTGGGCGCGTTTTCCGTGATTTCCTCGGACAGCCAGGCGATGGGCCGGATCGGAGAGGTGATCA TCCGCACCTGGCAGACCGCCGACAAGATGCGCCGCCAGCGCGGGCGCCTGGCGGGCGAGACGGGCGAGAACGACAACCTG CGCGCCCGCCGCTATATCGCGAAATACACCATCAACCCGGCCATCGCGCATGGCATCAGCACCCATGTCGGCAGCATCGA GCCAGGCAAGCGCGCCGATCTGGTGCTGTGGTCGCCCGCCTTCTTCGGCGTCAAGCCCGAGATGGTGCTGGTCGGCGGCC GGATCAGCGTGGCGCAGATGGGCGATCCCAACGGCTCGATCCCGGTGCAGCCGATCTTCAGCCGCCCGATGTGGGGGCAT GCCGGCCGCGCATCGGCCCTGTTTCTCAGCCGGGCGGGGCTCGAAGCCGGGGCGGGCGACGGCTTGGGCAAGGCGTTGAT CGCGGTCGAGCAGACCCGCGGCATCGGCAAGGCGGACATGGTCCTGAACGATGCGATGCCGCAGATCGAGGTCGACCCCG AAACCTACGAGGTCCGCGCCGACGGCGAATTGCTGACCTGCGAACCCGCCACGGAACTGCCCATGGCGCAACGATATTTC CTGTTCTGA Protein sequence : MGQTLSRADYAALYGPTTGDRIRLADTELLIEVERDLTIPGEEVRFGGGKVVRDGMGQSQVTREAGAMDTVITGAVVFDH QGITKADVGLRDGRIAGIGKAGNPDTQPGVTLIIGPGTEIIAGEGRILTPGGMDCHIHFICPQQVDHALHSGVTTLLGGG TGPAHGTLATTCTPGPWHIARMLEACAELPVNIGIAGKGNASLPAALEEQVRAGACALKLHEDWGTTPAAIDCCLTVADA MDVQVMIHTDTLNESGFVEDTMAAIAGRTIHAYHTEGAGGGHAPDIIRMVGMGNVLPSSTNPTRPYTGNTIEEHLDMLMV CHHLDRRVPEDVAFAESRIRRETIAAEDILHDLGAFSVISSDSQAMGRIGEVIIRTWQTADKMRRQRGRLAGETGENDNL RARRYIAKYTINPAIAHGISTHVGSIEPGKRADLVLWSPAFFGVKPEMVLVGGRISVAQMGDPNGSIPVQPIFSRPMWGH AGRASALFLSRAGLEAGAGDGLGKALIAVEQTRGIGKADMVLNDAMPQIEVDPETYEVRADGELLTCEPATELPMAQRYF LF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 8e-161 | 66 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 8e-161 | 66 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-150 | 59 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-150 | 59 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 3e-150 | 59 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-150 | 59 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_915009.1 | urease subunit alpha | VFG0270 | Protein | 1e-139 | 59 |
