Gene Information

Name : guaA (BAD_0686)
Accession : YP_909549.1
Strain : Bifidobacterium adolescentis ATCC 15703
Genome accession: NC_008618
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 859064 - 860626 bp
Length : 1563 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGGCTGCAGGTCCTGTGCTCGTTGTCGATTTCGGAGCCCAGTACGCCCAGCTGATCGCACGTCGCGTGCGTGAGGCCAA
TGTTTATTCGGAGCTCGTGCCGCATTCCATGCCGGTCGATGAGATGCTGGCCAAGGATCCGCAGGCCATCATCCTGTCCG
GTGGCCCCGCTTCCGTGTTCGAACCGGGCGCTCCGCGCGTCGACAAGAAGCTGTTCGACGCGGGCGTTCCGGTGCTCGGC
ATCTGCTACGGCTTCCAAGCCATGGCATACGCGTTGGGCGCGGATGTCGACAAGGCCGCCCTGGGCGAATACGGCAAAAC
GGAAACCACCATCGACAAGGCGGAGGGTCTGCTCGACGGCTCTCCCGCAGAGCAAAGCACGTGGATGAGCCATGGCGTGG
CCGTCAAGACCGCGCCGGAAGGCTTCGAAGTGCTCGCCCACACCGAAGGCGCACCGGTCGCCGCCATGCAGGACGAGTCC
CGCAAACTGTACGGCGTGCAGTGGCATCCGGAAGTCAAGCACACTCCGATGGGCCAGAAGCTCATCGAGAACTTCCTGCA
CAAGTGCGCCGGCCTCGGCGATAACTGGAACGCGTCCAACATCATCGAGGACCAGGTCAAGAAAATCCGCGAGAAGGTCG
GCGACGCCCAGGTGATTTGCGGCCTGTCCGGCGGCGTCGACTCCGCCGTCGCGGCGGCTCTGGTGCATAAGGCCATCGGC
GAGCAGCTCACCTGCGTGTTCGTGGACCACGGTCTGCTGCGCAAGGGCGAGGCCGAGCAGGTCAAACATGATTTCGTCGA
GGCCACCGGCATCAAGCTCATCGCCGTGGACGCCTCCGAAGACTTCCTCACCGCCCTGAAGGGTGTGAGCGAGCCGGAGA
AGAAGCGCAAGATCATCGGAGAGAAGTTCATCCGCACGTTCGAGAAGGCCCAGCGTCAGGTCATCGAAGAGGCCGGTGCC
TCCGGCAAGGAAGTCAAATTCCTCGTGCAGGGCACGCTGTATCCGGACGTCGTAGAGTCCGGCGGCGGCGATGGCGCGGC
CAACATCAAATCGCACCACAATGTGGGCGGCCTGCCGAAGGACATCAAATTCCAGCTCATCGAGCCACTGCGCACCCTGT
TCAAGGATGAGGTGCGCGCCATTGGCACCGAACTCGGTCTGCCGGATGAGATTGTCTGGCGTCAGCCATTCCCGGGTCCG
GGTCTCGGCATCCGCATCATCGGCGAAATCACCAAGGAACGTCTTGACTTGCTGCGCGAAGCTGATGCCATCGCACGTGA
GGAGCTTTCCAAGGCCGGCCTCGACCGCGACATCTGGCAGTGCCCGGTCGTGCTGCTTGCCGACGTGCATTCCGTGGGCG
TGCAGGGTGACGAACGCACCTACGGCTCGCCAATCGTGTTGCGTCCGGTGTCGTCCGAAGACGCCATGACCGCCGACTGG
TCGCGTATCCCGTACGACGTGCTCGCCACCATCTCGACGCGTATTACCAACGAATGCCGTCAGATCAACCGCGTGGTGCT
TGACTGCACTTCCAAGCCGCCGGCAACCATCGAATGGGAGTGA

Protein sequence :
MAAGPVLVVDFGAQYAQLIARRVREANVYSELVPHSMPVDEMLAKDPQAIILSGGPASVFEPGAPRVDKKLFDAGVPVLG
ICYGFQAMAYALGADVDKAALGEYGKTETTIDKAEGLLDGSPAEQSTWMSHGVAVKTAPEGFEVLAHTEGAPVAAMQDES
RKLYGVQWHPEVKHTPMGQKLIENFLHKCAGLGDNWNASNIIEDQVKKIREKVGDAQVICGLSGGVDSAVAAALVHKAIG
EQLTCVFVDHGLLRKGEAEQVKHDFVEATGIKLIAVDASEDFLTALKGVSEPEKKRKIIGEKFIRTFEKAQRQVIEEAGA
SGKEVKFLVQGTLYPDVVESGGGDGAANIKSHHNVGGLPKDIKFQLIEPLRTLFKDEVRAIGTELGLPDEIVWRQPFPGP
GLGIRIIGEITKERLDLLREADAIAREELSKAGLDRDIWQCPVVLLADVHSVGVQGDERTYGSPIVLRPVSSEDAMTADW
SRIPYDVLATISTRITNECRQINRVVLDCTSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-171 68
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 9e-140 53
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 9e-140 53
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 8e-140 53