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Name : leuS (MUL_0056) Accession : YP_904302.1 Strain : Mycobacterium ulcerans Agy99 Genome accession: NC_008611 Putative virulence/resistance : Unknown Product : leucyl-tRNA synthetase Function : - COG functional category : J : Translation, ribosomal structure and biogenesis COG ID : COG0495 EC number : 6.1.1.4 Position : 51796 - 54726 bp Length : 2931 bp Strand : + Note : leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl DNA sequence : GTGACCGAATCGCCGACCACGACACCTGGCAGCACGTCCGGTGCCCCCTCTGGTGTCCCCTCCGGTGTTAACGACGCGGA ATCCGACGCTCCGCGGCATCGCTACACCGCCGAGCTAGCGGCCGGAGTGGAGCGGACCTGGCAGCAAAACTGGGCCCGCC TGGGCACGTTCAACGTGCCCAACCCGGTTGGATCGCTCGCACCGTCGGACGGTTCCCCGGTGCCCGAGGACAAGCTGTTC GTCCAGGACATGTTTCCCTATCCATCCGGGGAGGGCCTGCACGTCGGGCACCCGTTGGGCTACATCGCCACCGACGTGTT CGCCCGCTATCACCGGATGAAGGGCCGCAACGTGCTGCATGCGTTGGGGTTCGACGCCTTCGGTCTGCCGGCCGAGCAGT ATGCCGTGCAAACCGGCACCCACCCACGGACCAGGACCGAGGCCAACGTCGTCAACTTCCGGCGCCAGCTGGGCCGGCTG GGGCTGGGCCACGACAGCCGGCGGAGCTTCTCCACCACCGACGTCGAGTTCTACAAGTGGACCCAGTGGATCTTCCTGCA GATCTACAACGCGTGGTTCGACGCGGCAGCCAACAAGGCTCGCCCGATATCGGAGTTGGTCGCAGAGTTTGATTCCGGGG CCAGAAGTCTGGTCGACGGCCGGGACTGGTCCACGCTGTCGGCGGGGGAGCGGGCCGACGTGATCGATGACCACCGGTTG GTCTACCGGGCGGATTCGATGGTGAATTGGTGTCCTGGACTGGGCACGGTGCTGGCCAACGAGGAAGTGACATCCGATGG ACGCAGCGACCGCGGCAACTTCCCCGTATTTCGCAAGCGGCTTCGGCAATGGATGATGCGGATCACCGCATACTCCGATC GGCTGCTCGACGACCTCGATGTGCTGGACTGGCCGGACCAGGTCAAGACCATGCAGCGCAACTGGATCGGGCGCTCGACG GGTGCCTCCGCGCTCTTTACGGCAACCAGGTCCAACGGTGAGACGGTCGGCCTCGAAGTGTTCACCACTCGCCCCGACAC CCTGTTCGGTGCCACCTATCTGGTTCTGGCCCCCGAACACGACCTGGTCGACGATCTAGTTGGGGCCGGGTGGCCAGCCG GTGTGGACCCGTTGTGGACCGGTGGTGGTGCCACGCCGGCCGAGGCCGTGGCCGCCTACCGTCGCGCTATCGCGGTCAAG TCCGACCTCGAGCGTCAGGAAAGCAAAGAGAAGACCGGCGTCTTCCTGGGTAGCCACGCGATCAATCCTGCCACTGGCCA GCCGGTGCCGATATTCATCGCTGACTACGTGCTGGCGGGGTACGGCACCGGGGCCATCATGGCAGTTCCGGGCCATGATC AGCGGGACTGGGATTTCGCGAGAGCACTGGGACTTCCGGTCGTCGAAGTCATTGCCGGCGGCGACATTTCGCAGGCCGCC TACACCGGCGACGGCGTCCTGGTGAACTCGGGATTCCTCGACGGCATGAGCGTGGGGGAGGCAAAGCAGGCCATCACCGC TCGGCTAGAGTCCGACGGTTATGGCCAGGCCCGCATCGAATTCAAGCTGCGTGACTGGCTTTTCGCGCGTCAGCGGTATT GGGGTGAACCATTCCCGATCGTGTACGACGCGGATGGACGCCCGCACGCACTTGATGAGTCGGCGCTTCCCGTCGAACTG CCCGATGTGCCGGACTATTCGCCGGTGCTTTTCGACCCCGACGATGCGAACAGCGAGCCGTCGCCGCCGCTGGGCAAGGC GACCGAGTGGCTGCACGTCGAGTTGGATCTCGGCGATGGGCTCAAGCCATACAGCCGCGACACCAACGTGATGCCGCAGT GGGCGGGCAGCTCCTGGTACGAGCTGCGCTATACCGATCCGCACAACGCAGATCGGTTCTGCGCCAAGGAAAATGAGACG TACTGGATGGGGCCGAGGCCGGCCGAACACGGCCCGGACGACCCGGGTGGCGTCGACTTGTACGTCGGTGGCGCCGAGCA CGCGGTGCTGCATCTGCTCTATGCCAGGTTCTGGCACAAGGTGTTGTACGACTTGGGCCACGTCAGCTCTCGCGAGCCCT ACCGCAAGCTGATCAACCAGGGCTACATTCAGGCCTTCGCCTATACCGACGCGCGGGGATCCTACGTACCTGCCGAAGAG GTCATCGAACGTGACGGCGGGTTTGTGTATCCCGGTGCCGACGGCGAGATCGAGGTCTTTCAGGAATTCGGGAAAATCGG TAAGAGCCTGAAGAATTCGATATCGCCCGACGAGATCTGCGACGACTATGGCGCGGACACCCTGCGGGTGTACGAGATGT CGATGGGCCCTATCGAGGCTTCACGCCCGTGGGCGACCAAAGACGTTATCGGCGCGCATCGCTTCTTGCAGCGGGTGTGG CGGCTGGTGATCGACGAAAACACGGGCGAGATCCTGGTGGCCGATACGCCCGCTGAGTTGGACACCGACACGCTGCGGGC GCTGCACCGCGCTATCGCCGGGGTGGCTGAAGACTATGCGGCACTGAGAAATAACACCGCGGTCGCCAAGCTGATCGAGT ACACCAACTTCCTCACCAAGCGCCATCGCGATGCCGTGCCCCGAGCTGTCATCGAGCCGCTGGTGCTGATGGTGGCCCCG CTGGCCCCGCACCTGGCCGAAGAGTTGTGGCAGCGGCTGGGTCACACCACTTCGTTGGCGCACGGACCATTCCCGGCGGC CGATCCGGCCTATCTGATCGACGACACCGTCGAATATCCGGTTCAGGTCAACGGCAAGGTGCGGGGCCGGGTTGTGGTGG CCGCCGACGCGGATGACGATGCGGTCAAAGCCGCTGCCCTAGCCGATCAGAAGGTGCAGGCGTTCCTGGCGGGCGCAAGC CCGCGGAAGGTGATTGTGGTCGCCGGCCGTCTGGTTAATCTTGTTGTTTGA Protein sequence : MTESPTTTPGSTSGAPSGVPSGVNDAESDAPRHRYTAELAAGVERTWQQNWARLGTFNVPNPVGSLAPSDGSPVPEDKLF VQDMFPYPSGEGLHVGHPLGYIATDVFARYHRMKGRNVLHALGFDAFGLPAEQYAVQTGTHPRTRTEANVVNFRRQLGRL GLGHDSRRSFSTTDVEFYKWTQWIFLQIYNAWFDAAANKARPISELVAEFDSGARSLVDGRDWSTLSAGERADVIDDHRL VYRADSMVNWCPGLGTVLANEEVTSDGRSDRGNFPVFRKRLRQWMMRITAYSDRLLDDLDVLDWPDQVKTMQRNWIGRST GASALFTATRSNGETVGLEVFTTRPDTLFGATYLVLAPEHDLVDDLVGAGWPAGVDPLWTGGGATPAEAVAAYRRAIAVK SDLERQESKEKTGVFLGSHAINPATGQPVPIFIADYVLAGYGTGAIMAVPGHDQRDWDFARALGLPVVEVIAGGDISQAA YTGDGVLVNSGFLDGMSVGEAKQAITARLESDGYGQARIEFKLRDWLFARQRYWGEPFPIVYDADGRPHALDESALPVEL PDVPDYSPVLFDPDDANSEPSPPLGKATEWLHVELDLGDGLKPYSRDTNVMPQWAGSSWYELRYTDPHNADRFCAKENET YWMGPRPAEHGPDDPGGVDLYVGGAEHAVLHLLYARFWHKVLYDLGHVSSREPYRKLINQGYIQAFAYTDARGSYVPAEE VIERDGGFVYPGADGEIEVFQEFGKIGKSLKNSISPDEICDDYGADTLRVYEMSMGPIEASRPWATKDVIGAHRFLQRVW RLVIDENTGEILVADTPAELDTDTLRALHRAIAGVAEDYAALRNNTAVAKLIEYTNFLTKRHRDAVPRAVIEPLVLMVAP LAPHLAEELWQRLGHTTSLAHGPFPAADPAYLIDDTVEYPVQVNGKVRGRVVVAADADDDAVKAAALADQKVQAFLAGAS PRKVIVVAGRLVNLVV |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| leuS | YP_281511.2 | leucyl-tRNA synthetase | Not tested | Not named | Protein | 3e-137 | 46 |
