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Name : ethA (MUL_5026) Accession : YP_908372.1 Strain : Mycobacterium ulcerans Agy99 Genome accession: NC_008611 Putative virulence/resistance : Unknown Product : monooxygenase EthA Function : - COG functional category : P : Inorganic ion transport and metabolism COG ID : COG2072 EC number : - Position : 5571318 - 5572787 bp Length : 1470 bp Strand : - Note : cytoplasmic protein; activates the pro-drug ethionamide (eth); induced eth sensitivity when overexpressed in mycobacterium tuberculosis. DNA sequence : ATGACTGAGCATCTTGACGTCGTGATCGTGGGGGCGGGTATCTCCGGCGTGAGTGCAGCCTGGCATCTTCAAGACCGCTG TCCGACCAAGTCCTACGCGATCCTGGAGAAGCGCGCCGCCATGGGTGGCACCTGGGAGCTGTTCCGCTACCCCGGCATCC GATCCGACTCCGATATGCACACGCTGGGCTTCCGCTTTCGTCCGTGGACCGAGCGCCAGGCCATCGCCGACGGCAAGCCG ATCCTCGAATACGTCAAAGGCACGGCGGCCATGTACGGCATCGACAAGCACATCCGGCTCAACCAGAAAGTCATCAGCGC GGACTGGTCGAACGCGCAGAACCGCTGGACGCTGCAGATCGAGAGCAACGGTGCCATGAGCGCCGTCACCTGTTCGTTCC TGTTTCTCTGCAGCGGCTACTACAACTACGACCAGGGCTACACCCCGAACTTCGCCGGCGCGCAGGACTTCGCCGGCTCG ATCATCCATCCGCAGCACTGGCCCGAAGACCTCGACTATGACGGCAAGAACGTCGTCGTGATCGGCAGCGGTGCCTCCGC GGTCACTCTGGTCCCGGCGCTGGCGAACTCGGGGGCAAAGCACGTCACGATGCTGCAGCGCTCGCCGACCTACATAGTCT CCCAGCCAGAACGGGACAGCATCGCTGAGCGCCTCAACCGCTGGCTTCCCGAGAACATGGCCTACGCCATGGTGCGGTGG AAGAACGTGCTGCGCCAGGCCGCCGTATACGGAGCCTGCCGCAAGTGGCCGCGGCGAATGCGGAAGAACTTCATGGGACT GGCCCAGCGTCAGTTGCCCGAAGGCTATGACGTGCGAAAGCATTTCGGCCCGCACTACAACCCATGGGATCAGCGGCTAT GCCTGGTGCCCAACGGCGACTTGTTCCGGGCCATTCGCCACGGACAGGTCGATGTGGTCACCGACACGATCGACCGGTTC ACGCCGACCGGCATCCGGCTCAACTCGGGCCAGCAGCTGCCGGCCGACATCATCGTCACCGCAACGGGTTTGAACCTGCA GCTCTTCGGCGGGGCGGCGGTCACCGTGGACGGAGAGTCGGTGGATCTCACCAAGGCGATGGCCTACAAGGGCATGATGC TTTCCGGCCTGCCCAACATGGCCTACACCGTTGGCTACACCAACGCGTCGTGGACACTGAAGGCGGATCTGGTGTCGGAG TTCGTTTGCCGTCTGCTCAACTACATGGACGCCAATGACTATGAGTCCGTCGTCGTCGAGCGCCCGGGTTCGGATGTGCA GGAATGTCCATTCATGGAGTTCACTCCGGGCTATGTGCTGCGCGTGATCGACGAACTTCCCAAGCAGGGTTCACGCAAGC CGTGGCGACTCAACCAGGACTATCTGCGCGATATTCATCTGATTCGCCGCGGCAAGATCGACGACGAGGGTTTGCGATTC GCCAAAAAGCCGGTCGCAGTGCCGGTTTAG Protein sequence : MTEHLDVVIVGAGISGVSAAWHLQDRCPTKSYAILEKRAAMGGTWELFRYPGIRSDSDMHTLGFRFRPWTERQAIADGKP ILEYVKGTAAMYGIDKHIRLNQKVISADWSNAQNRWTLQIESNGAMSAVTCSFLFLCSGYYNYDQGYTPNFAGAQDFAGS IIHPQHWPEDLDYDGKNVVVIGSGASAVTLVPALANSGAKHVTMLQRSPTYIVSQPERDSIAERLNRWLPENMAYAMVRW KNVLRQAAVYGACRKWPRRMRKNFMGLAQRQLPEGYDVRKHFGPHYNPWDQRLCLVPNGDLFRAIRHGQVDVVTDTIDRF TPTGIRLNSGQQLPADIIVTATGLNLQLFGGAAVTVDGESVDLTKAMAYKGMMLSGLPNMAYTVGYTNASWTLKADLVSE FVCRLLNYMDANDYESVVVERPGSDVQECPFMEFTPGYVLRVIDELPKQGSRKPWRLNQDYLRDIHLIRRGKIDDEGLRF AKKPVAVPV |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| unnamed | AAK01510.1 | aromatic-ring hyroxylase | Not tested | PAGI-1 | Protein | 9e-121 | 53 |
