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Name : MUL_0494 (MUL_0494) Accession : YP_904667.1 Strain : Mycobacterium ulcerans Agy99 Genome accession: NC_008611 Putative virulence/resistance : Virulence Product : aldehyde dehydrogenase Function : - COG functional category : C : Energy production and conversion COG ID : COG1012 EC number : - Position : 510843 - 512366 bp Length : 1524 bp Strand : + Note : Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; interconversion aldehyde and acid [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH] DNA sequence : ATGACCGTGTTCGCACGTCCGGGCGTGCACAGTTCATTGATGACTTTCGAGTCCCGCTACGACAACTTCATCGGCGGCGA GTGGGTCGCGCCGGCCGCAGGCGAGTACTTCGAGGACCTAACCCCGGTAACCGGCGCACCGTTCTGCGAGGTGCCACGCT CCACCGATGTCGATGTCGAAAAGGCACTCGACGCGGCCCACGCCGCGGCGCCCGCCTGGGGCAAGGCCGCACCCGCCGAG CGGGCAACGATTCTGCACAAGATCGCCGATCGGATGGAGGCGAACCTCGAAGCGCTCGCGCTGGCCGAGTCCTGGGACAA CGGCAAGCCGATCCGCGAGGCGCTCAACGCCGACATTCCGCTGGCGATCGACCACTTCCGGTACTTCGCCGGGGCCATCC GCGCCCAGGAAGGCTCGCTGAGCCAAATCGACTCCGACACCGTGGCCTATCACTTCCATGAACCGCTGGGCGTGGTGGGT CAGATCATCCCGTGGAACTTCCCGCTGTTGATGGCCACCTGGAAGCTGGCCCCCGCCCTGGCCGCCGGCAACGCCGTTGT GCTCAAGCCCGCCGAGCAGACCCCGGCCTCGATCCTGTACCTGATGAGTCTGATCGGTGACCTGCTACCCGCCGGTGTGG TCAACGTGGTCAACGGATTTGGGGTCGAGGCCGGCAAGCCGCTGGCATCGAGCAACCGGATCGCCAAGATCGCCTTCACC GGAGAGACCACCACCGGACGGCTGATTATGCAATATGCCAGCCAGAACCTGATCCCGGTGACGCTGGAGCTGGGCGGCAA GAGCCCCAACATCTTCTTCCCCGACGTGCTGGCCGCCCACGACGACTACCAGGACAAGGCGCTGGAGGGCTTCACCATGT TCGCCCTCAACCAGGGCGAGGTGTGCACCTGCCCGTCCCGCGGCCTGATTCAGGCCGACATCTACGACCGGTTCCTGGAA CTGGCGGCGATCCGCACCAAGGCCGTGCGCCAGGGGGATCCACTCGACACCGAGACCATGATCGGCGCGCAGGCCTCCAA CGACCAGCTGCAAAAGATCTTGTCCTACATCGAGATCGGCAAAGAGGAGGGTGCGCGGGTGGTCACCGGGGGTGAGCGCT GCGAACTGGGCGGCGACCTCAACGGCGGCTACTACGTGCAGCCCACCATCTTCGAAGGCACCAACAACATGCGCATCTTC CAAGAGGAGATCTTCGGCCCGGTGGTCTCGGTCACCTTGTTCACCGATTACGACGACGCGATCCGCATCGCCAACGACAC CCTCTACGGGCTGGGCGCGGGTGTGTGGAGCCGTGACGGCAACACCGCGTATCGGGCCGGGCGTGACATCAAGGCCGGCC GCGTCTGGACGAACTGCTACCACGCCTATCCCGCCCACGCGGCGTTCGGCGGCTACAAGCAGTCCGGCATCGGACGCGAG AACCACAAGATGATGCTCGACCACTACCAGCAGACCAAGAACCTGCTGGTGTCCTACGGCAGCAAGGCCCAGGGCTTCTT CTGA Protein sequence : MTVFARPGVHSSLMTFESRYDNFIGGEWVAPAAGEYFEDLTPVTGAPFCEVPRSTDVDVEKALDAAHAAAPAWGKAAPAE RATILHKIADRMEANLEALALAESWDNGKPIREALNADIPLAIDHFRYFAGAIRAQEGSLSQIDSDTVAYHFHEPLGVVG QIIPWNFPLLMATWKLAPALAAGNAVVLKPAEQTPASILYLMSLIGDLLPAGVVNVVNGFGVEAGKPLASSNRIAKIAFT GETTTGRLIMQYASQNLIPVTLELGGKSPNIFFPDVLAAHDDYQDKALEGFTMFALNQGEVCTCPSRGLIQADIYDRFLE LAAIRTKAVRQGDPLDTETMIGAQASNDQLQKILSYIEIGKEEGARVVTGGERCELGGDLNGGYYVQPTIFEGTNNMRIF QEEIFGPVVSVTLFTDYDDAIRIANDTLYGLGAGVWSRDGNTAYRAGRDIKAGRVWTNCYHAYPAHAAFGGYKQSGIGRE NHKMMLDHYQQTKNLLVSYGSKAQGFF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| VC0819 | NP_230467.2 | aldehyde dehydrogenase | Not tested | VPI-1 | Protein | 2e-133 | 63 |
| aldA | AAC12273.1 | aldehyde dehydrogenase | Virulence | VPI | Protein | 2e-140 | 61 |
| aldA | AAK20747.1 | aldehyde dehydrogenase | Virulence | VPI | Protein | 2e-140 | 61 |
| aldA | AAK20776.1 | aldehyde dehydrogenase | Virulence | VPI | Protein | 2e-140 | 61 |
| aldA-1 | YP_001216300.1 | aldehyde dehydrogenase | Not tested | VPI-1 | Protein | 7e-140 | 61 |
| ORF SG19 | AAN62241.1 | putative aldehyde dehydrogenase | Not tested | PAGI-3(SG) | Protein | 3e-62 | 44 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| MUL_0494 | YP_904667.1 | aldehyde dehydrogenase | VFG0082 | Protein | 9e-134 | 63 |
