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Name : mbtA (MUL_3641) Accession : YP_907245.1 Strain : Mycobacterium ulcerans Agy99 Genome accession: NC_008611 Putative virulence/resistance : Virulence Product : bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase Function : - COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism COG ID : COG1021 EC number : - Position : 4050636 - 4052249 bp Length : 1614 bp Strand : + Note : membrane protein; involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins (initiation step of mycobactin chain growth) activates the mycobactin ACP in two half-reactions: activates salicylic acid as acyladenylate (adeny DNA sequence : GTGGCCGGGTTCATTCCGTACCCACCCGAACGAGTGGCCAGCTACCGCGCCGCCGGTTATTGGACCGGTCGCAGCATCGG CTCGCTGTTGCGGCAAGCGGCCGCACGCTGGCCTGACCGAGTGGGTGTGGTCGACGCCGGCGCCAGCCATACGTTCTGCG AACTGGACAAACTGGCCGATCGAGTCGCCGCGGGCTTCGTTTCGCTGGGCATCGCACCGGGCGACCGGGTGCTGCTGCAG TTACCCAATTCGTGCCGGTTCGCGGTCGCCTTGTTCGGCCTGTTGCGCGCCGGAGCCATCCCGGTGATGTGCCTGCCCGG ACACCGGCTGGCAGAACTGCACCACTTCGCCGAGGTCAGCGGTGCGGTGGGTTTGATCGTCGCGCAGCACGCCGGCGGCT TCGACTACCGGTCGATGGCCGAGCGGTTGGTCGCCGCTCACCCCCAGTTGCGCCACGTCATCATCGACGGCGAGTCCGGG CCCTTTCTGCCGTGGTCGTCGCTGTCCGAAGGCGCCACACCCGACATCGATGTCGACACCACATCGCCCGCCTTGTTACT CGTCTCAGGTGGCACCACCGGCACTCCGAAACTGATCCCCCGAACACACGACGACTACGTTTACAACGCCACCGCGAGTG CGCAGTTGTGCCGGCTGACCGCTGACGACGTGTACCTCGTGTCGCTGCCGGCGGCGCACAACTTCCCGTTGGCATGTCCG GGCATACTCGGCTCGATGGCCGTCGGCGCCACCATCGTTTTCAGCACCGACCCCAGCCCGGAGGCCGCCTTCACCTTGAT CGAGCGCCACGGCGTCACCGTCACGGCGCTGGTACCCGCGCTGGCCAAACTGTGGACCCAGGCCTGTGATTGGGAGCCGG TAATCCCGAAGTCTTTGCGGCTATTGCAAGTTGGTGGCTCCAGATTGGAGCCCGAGGATGCTCGCCAGGCACGAGAGGCA TTGACCCCGGGGCTGCAACAGGTCTTCGGGATGGCCGAAGGACTGCTGAACTTCACCCGCCTCGAAGATCCGCCGGACCT CCTCGAGCACACCCAGGGCCGGCCCCTGTGCTCCGCTGACGAATTGCGCATTGTCGACGGCGCGGGCGCGCCGGTGGCTC CCGGCGCAGAGGGCGAGCTACTGGTGCGCGGTCCCTACACCATCAACGGCTACTTCTGCGCCGACCGAGACAACGAGCGC TGCTTCGATCCAGCCGGCTTCTATCGCAGCGGCGACTTGGTCCGACTCCGCGACGACGGCTACCTGCAGGTCACCGGGCG CGTCAAAGACGTCATCTGCCGCTGCGGTGAGACCATCTCGGCCCAGGACCTCGAAGAACAGTTGCTCAGCCACCCGGCGA TCCGCTCGGCCGCGGCGGTGCCACTGCCGGACCCGGATATGGGCGAGCTGATCTGCGCTGCAATTGTTTTCGCGGGGCCA CCGCAGACGCCGCAGACCTTGTCGGGACTCAATGACTATCTCGAGCAGCGTGGCGTGGCCGCACATATCCGCATCGATCG GCTGGTCGCGATGCCGTCGCTGCCGACCACACCGGTGGGAAAGATCGACAAGAAGGCGATCGCGAGCCAGATCCTGACAA CCACGGCGACCTGA Protein sequence : MAGFIPYPPERVASYRAAGYWTGRSIGSLLRQAAARWPDRVGVVDAGASHTFCELDKLADRVAAGFVSLGIAPGDRVLLQ LPNSCRFAVALFGLLRAGAIPVMCLPGHRLAELHHFAEVSGAVGLIVAQHAGGFDYRSMAERLVAAHPQLRHVIIDGESG PFLPWSSLSEGATPDIDVDTTSPALLLVSGGTTGTPKLIPRTHDDYVYNATASAQLCRLTADDVYLVSLPAAHNFPLACP GILGSMAVGATIVFSTDPSPEAAFTLIERHGVTVTALVPALAKLWTQACDWEPVIPKSLRLLQVGGSRLEPEDARQAREA LTPGLQQVFGMAEGLLNFTRLEDPPDLLEHTQGRPLCSADELRIVDGAGAPVAPGAEGELLVRGPYTINGYFCADRDNER CFDPAGFYRSGDLVRLRDDGYLQVTGRVKDVICRCGETISAQDLEEQLLSHPAIRSAAAVPLPDPDMGELICAAIVFAGP PQTPQTLSGLNDYLEQRGVAAHIRIDRLVAMPSLPTTPVGKIDKKAIASQILTTTAT |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ybtE | YP_070120.1 | yersiniabactin siderophore biosynthetic protein | Virulence | HPI | Protein | 6e-94 | 46 |
| ybtE | CAA21394.1 | - | Virulence | HPI | Protein | 6e-94 | 46 |
| irp5 | YP_001006819.1 | yersiniabactin siderophore biosynthetic protein | Virulence | HPI | Protein | 2e-94 | 46 |
| ybtE | AAA93464.1 | yersiniabactin 2,3-dihydoxybenzoate-AMP ligase | Virulence | HPI | Protein | 4e-94 | 46 |
| irp5 | CAA73130.1 | Irp5 protein | Virulence | HPI | Protein | 1e-94 | 46 |
| ybtE | YP_853079.1 | yersiniabactin siderophore biosynthetic protein | Virulence | PAI IV APEC-O1 | Protein | 6e-94 | 46 |
| irp5 | YP_002346898.1 | yersiniabactin siderophore biosynthetic protein | Virulence | HPI | Protein | 6e-94 | 46 |
| ybtE | NP_669710.1 | salicyl-AMP ligase | Virulence | HPI | Protein | 6e-94 | 46 |
| ybtE | NP_993003.1 | yersiniabactin siderophore biosynthetic protein | Virulence | HPI | Protein | 6e-94 | 46 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| mbtA | YP_907245.1 | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase | VFG1817 | Protein | 0.0 | 73 |
| mbtA | YP_907245.1 | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase | VFG0168 | Protein | 2e-87 | 44 |
