Gene Information

Name : tpx (MUL_2894)
Accession : YP_906643.1
Strain : Mycobacterium ulcerans Agy99
Genome accession: NC_008611
Putative virulence/resistance : Virulence
Product : thiol peroxidase
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG2077
EC number : -
Position : 3219685 - 3220182 bp
Length : 498 bp
Strand : -
Note : antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein

DNA sequence : 
ATGGCACAGATAACCCTGCGTGGAAATGCGATCAACACTGTCGGCGAACTGCCTGCCGTCGGATCTCCTGCCCCGGCATT
CGCCCTTACCGGTGATGACCTGGGAACGGTGAGCAGCGACCAGTTCCGCGGCAAGGCCGTCGTGCTGAATATCTTCCCGT
CCATCGATACACCGGTGTGCGCAACCAGTGTTCGGACCTTCAACGAGCGTGCCGCCGCCAGCGGAGTGAACGTGCTCTGC
GTGTCGAAAGACCTGCCGTTTGCGCAGAAGCGATTCTGTGGGGCGGAGGGGATCGAGAACGTGACAAACGCCTCGGCGTT
CCGTGACGGCTTCGGTGAGGCCTACGGCGTCACCATCACCGACGGCCCGATGGCCGGACTCCTTGCCCGGGCCATCGTGG
TCATCGGCGCCGACGGCAAAGTTTCCTACACCGAACTGGTGCCGGAAATCGCGCAAGAGCCCGACTACGAAGCGGCGCTG
GCAGCAGTCGGCACCTAG

Protein sequence : 
MAQITLRGNAINTVGELPAVGSPAPAFALTGDDLGTVSSDQFRGKAVVLNIFPSIDTPVCATSVRTFNERAAASGVNVLC
VSKDLPFAQKRFCGAEGIENVTNASAFRDGFGEAYGVTITDGPMAGLLARAIVVIGADGKVSYTELVPEIAQEPDYEAAL
AAVGT

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tpx NP_230472.1 thiol peroxidase Virulence VPI-1 Protein 5e-34 45
tagD AAK20781.1 toxR-activated gene D protein Virulence VPI Protein 4e-34 45
tpx YP_001216305.1 thiol peroxidase Not tested VPI-1 Protein 6e-34 44
tagD AAK20751.1 toxR-activated gene D protein Virulence VPI Protein 4e-34 44

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
tpx YP_906643.1 thiol peroxidase VFG0087 Protein 2e-34 45