Gene Information

Name : metB (MUL_0201)
Accession : YP_904423.1
Strain : Mycobacterium ulcerans Agy99
Genome accession: NC_008611
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 203528 - 204694 bp
Length : 1167 bp
Strand : -
Note : catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine

DNA sequence :
ATGAAGGACGATCACAAGGCGCAGCACCGGTTCGCCGGACTCGCAACACGAGCCATTCATTCCGGCTATCGCCCGGACCC
GGCGACCGGAGCCGTCAACGCTCCGATCTATGCCAGCAGCACCTTCGCCCAGGATGGTGTCGGCGGGCTTCGGGGCGGCT
ATGAGTATGCGCGAACCGGCAATCCGACTCGCACCGCCTTGGAAGCCGCGCTTGCCGCGGTTGAAGACGCGGCGTTCGGG
CGTGCGTTCAGTTCCGGCATGGCCGCCGCCGACTGCGCGCTGCGGGCAATGCTGCGACCGGGTGACCATGTCGTCATCCC
CGACGACGCCTACGGCGGCACCTTCCGGTTGATTGACAAGGTCTTCACCGGGTGGAACGTCGAGTACACACCGGTAGCCC
TGGCGGATCTGGATGCGGTGCGTGCGGCGATAAGGCCAACCACCCGACTGATTTGGGTGGAAACACCGACCAATCCGCTG
CTGTCGATCGCCGACATCGCCGGCATCGCCCAGCTGGGTGCGGACAGCTCGGCGAAAGTTCTGGTGGACAACACCTTCGC
ATCTCCGGCGCTGCAGCAGCCGCTATCGCTGGGCGCCGACGTGGTGCTGCATTCCACCACCAAATACATCGGTGGTCACT
CCGATGTGGTGGGTGGCGCACTGGTGACCAATGACGAAGAGCTGGACCAGTCTTTTGCCTTCTTGCAGAACGGGGCGGGC
GCGGTGCCGGGCCCGTTCGACGCGTACCTGACCATGCGCGGCCTGAAAACCCTGGTCCTGCGCATGCAGCGGCATAGTGA
AAATGCCGCTGCCGTGGCGGAATTCCTCGCCGAACATCCCGCGATCAGCACCGTGTTGTACCCAGGGCTGCCCAGTCACC
CCGGCCATGCCGTGGCGGCGCGGCAGATGCGCGGGTTTGGCGGCATGGTTTCGGTGCGGATGCGAGCCGGCCGCACCGCC
GCCGAACAGCTGTGCGCCAAGACGAACATCTTCATCCTGGCCGAATCGCTAGGCAGTGTGGAGTCGCTGATCGAGCATCC
CAGCGCGATGACTCACGCGTCGACCGCGGGTTCGCAGCTGGAAGTGCCCGATGACCTGGTGCGGCTGTCGGTCGGTATCG
AAGACGTTGCCGATCTCCTCGACGACCTCAAACAGGCGCTGGGCTAA

Protein sequence :
MKDDHKAQHRFAGLATRAIHSGYRPDPATGAVNAPIYASSTFAQDGVGGLRGGYEYARTGNPTRTALEAALAAVEDAAFG
RAFSSGMAAADCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTGWNVEYTPVALADLDAVRAAIRPTTRLIWVETPTNPL
LSIADIAGIAQLGADSSAKVLVDNTFASPALQQPLSLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDQSFAFLQNGAG
AVPGPFDAYLTMRGLKTLVLRMQRHSENAAAVAEFLAEHPAISTVLYPGLPSHPGHAVAARQMRGFGGMVSVRMRAGRTA
AEQLCAKTNIFILAESLGSVESLIEHPSAMTHASTAGSQLEVPDDLVRLSVGIEDVADLLDDLKQALG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-70 47
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-71 47
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 2e-50 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
metB YP_904423.1 cystathionine gamma-synthase BAC0207 Protein 9e-60 43