Gene Information

Name : drrA (MUL_2014)
Accession : YP_905924.1
Strain : Mycobacterium ulcerans Agy99
Genome accession: NC_008611
Putative virulence/resistance : Unknown
Product : daunorubicin-DIM-transport ATP-binding protein ABC transporter DrrA
Function : -
COG functional category : V : Defense mechanisms
COG ID : COG1131
EC number : -
Position : 2239645 - 2240640 bp
Length : 996 bp
Strand : -
Note : Detected in the membrane fraction by proteomics; membrane protein; probably involved in active transport of antibiotic and phthiocerol dimycocerosate (DIM) across the membrane (export) DrrA, DrrB and DrrC may act jointly to confer daunorubicin and doxorub

DNA sequence :
ATGCGTAACAACGACTTGGCGGTAGAGGTTCGCGGGGTTCGCAAGGCCTTTGGCGACGTCGTGGCTCTCAACGACATCAG
TTTCGAGGTTGGCCGCGGCGAGGTCATCGGTCTACTCGGCCCGAACGGGGCGGGCAAGACGACCATGGTGGACATCTTGT
CCACCTTGACCCGCCCGGATGCCGGCTCGGCCCACGTCGCCGGCTACGACGTCGTCGCCCAGCCGGCCGGAGTGCGGCGC
TCGATCATGGTCACCGGGCAACAAGTGGCCGTCGACGACGGGCTGACCGGGGAGCAGAACCTGGTGTTGTTCGGCCGCCT
CTACGGGCTGCGCAAGTCCCGTGCTCGCCAGCGGGCGCAGGAACTCCTCGATCAATTTGGCCTCACCTATGCCGGCAAGC
GGCTGGTGCGCACCTACTCAGGCGGGATGCGTCGACGCATCGACATCGCGTGCGGACTGGTGGTCGAGCCGCAAGTGGCG
TTCTTGGACGAGCCGACCACGGGGCTGGATCCCAGAAGCCGACAAGCCATTTGGGACCTGGTCACCAGTTTCAAGAAGCT
TGGCATCGCCACCCTGCTGACCACGCAGTATCTCGAGGAGGCGGACGCGCTCAGCGACCGGATCATCCTGATCGATCACG
GCAAGATCATTGCCGACGGTACTGCCAATGAGCTCAAGCACCGCGCCGGCGACACCTTCTGCGAGATTGTGCCGCGGCAT
CTGAAAGATCTGGACGCTACCGTCGCCGCCCTCGGCTCGCTGTTGCCCGAGCACAACAGGGCCATGGTGACCTCGGAATC
GGACCGCATCACGATGCCGGCTCCCGATGGCACCCGCACCCTCATCGAAGCAGCCCGAAAGATCGATGAGGCCAATATCG
AGCTGGCCGACATCGCGCTGCGCCGGCCGTCTCTTGATGACGTATTCCTTTCCATGACAACCGATCCCAGCGAGGCCCAC
GTGCTGAGTCACGTGGCGTCGGGGGCCATGCTGTGA

Protein sequence :
MRNNDLAVEVRGVRKAFGDVVALNDISFEVGRGEVIGLLGPNGAGKTTMVDILSTLTRPDAGSAHVAGYDVVAQPAGVRR
SIMVTGQQVAVDDGLTGEQNLVLFGRLYGLRKSRARQRAQELLDQFGLTYAGKRLVRTYSGGMRRRIDIACGLVVEPQVA
FLDEPTTGLDPRSRQAIWDLVTSFKKLGIATLLTTQYLEEADALSDRIILIDHGKIIADGTANELKHRAGDTFCEIVPRH
LKDLDATVAALGSLLPEHNRAMVTSESDRITMPAPDGTRTLIEAARKIDEANIELADIALRRPSLDDVFLSMTTDPSEAH
VLSHVASGAML

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
CDC7B_2054 YP_005163495.1 methionine import ATP-binding protein Not tested Not named Protein 2e-60 44
CDCE8392_1976 YP_005134507.1 methionine import ATP-binding protein Not tested Not named Protein 2e-60 44