Gene Information

Name : nrdE (MUL_1878)
Accession : YP_905811.1
Strain : Mycobacterium ulcerans Agy99
Genome accession: NC_008611
Putative virulence/resistance : Unknown
Product : ribonucleotide-diphosphate reductase subunit alpha
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0209
EC number : 1.17.4.1
Position : 2078270 - 2080351 bp
Length : 2082 bp
Strand : +
Note : Catalyzes the rate-limiting step in dNTP synthesis

DNA sequence :
ATGCTGAATCTGTACGACGCGGACGGCAAGATTCAGTTCGACAGGGACGTTCTTGCCGCACGTCAGTTTTTCCTGCAGCA
CGTCAACCAGAACACGGTCTTCTTCCATAACCAGGACGAGAAGCTCGACTATCTGATCCGCGAGAACTACTACGAGCGTG
AGGTGCTCGATCAGTACTCGCGCAACTTCGTCAAGGCGCTGCTCGATCGCGCCTATGCAAAGAAGTTCCGGTTCCCGACG
TTCTTGGGGGCGTTCAAGTACTACACCTCCTACACGTTGAAGACCTTCGACGGCAAGCGCTACCTGGAACGCTTCGAGGA
CCGCGTGGTCATGGTGGCGCTGACGCTGGCCTCCGGTGACGCGACGTTGGCCGAGAAGCTCGTCGACGAAATCATCGACG
GTCGGTTCCAGCCGGCCACGCCGACCTTTTTGAACTCCGGCAAGAAGCAGCGCGGCGAGCCGGTGAGCTGCTTTCTGCTG
CGCATCGAGGACAACATGGAGTCGATCGGACGATCGATCAACTCCGCGTTGCAGCTGTCCAAGCGGGGTGGGGGAGTAGC
GCTGCTGCTGACCAACATCCGCGAGCATGGTGCGCCGATCAAAAACATCGAGAATCAGTCGTCGGGCGTCATCCCGATCA
TGAAGCTGCTCGAGGACTCGTTCTCCTACGCCAATCAGTTGGGGGCGCGTCAGGGTGCCGGCGCGGTGTACCTGCACGCG
CACCATCCCGACATCTACCGCTTCCTGGACACCAAGCGCGAGAACGCCGACGAGAAGATCCGGATCAAGACCCTGAGCCT
GGGGGTGGTGATCCCGGACATCACCTTCGAGTTGGCCAAGCGCAACGACGACATGTACCTCTTCTCGCCCTACGACGTCG
AACGCGTCTACGGTGTGCCGTTCGCCGACATCTCGGTGACCGAGAAGTACTACGAGATGGTCGACGACTCGCGCATCCGC
AAGACCAAGATCAAAGCGCGAGAGTTCTTTCAGACGCTGGCCGAGCTGCAGTTCGAGTCCGGCTACCCCTACATCATGTT
CGAAGACACGGTGAACCGGGCCAACCCCATTGAGGGCAAGATCACCCACAGCAACCTGTGCTCGGAGATCCTGCAGGTGT
CCACGCCGTCGTTGTTCAACGACGACTTGTCGTACGCCAAGGTGGGCAAGGACATTTCCTGCAACCTGGGCTCACTGAAC
ATCGCCAGGACCATGGATTCCCCGGACTTCGCCCAGACCATCGAGGTGGCGATCCGGGCGCTGACGGCGGTCAGCGACCA
GACGCACATCACCTCGGTGCCCTCAATCGAGCAGGGGAACAACGACTCCCACGCCATCGGTCTGGGACAGATGAACCTGC
ATGGCTACCTGGCCCGCGAACACATCTTCTACGGCTCCGAAGAAGGCGTTGACTTCACCAACATCTACTTCTATGCGGTG
CTCTACCACGCGCTGCGGGCGTCCAACCGAATCGCGGTCGAACGCGGCACGCGCTTCAAGGGTTTCGACCAATCCAAGTA
CGCATCGGGGGAGTTCTTCGACAAGTACACCGAACGGGTTTGGGAGCCGAAAACCGAGAAGGTGCGCCAGCTCTTCGCCG
ACGCGGGCATCCGCATTCCCAACCAGGACGACTGGCAGCGGTTGAAGGAGTCCGTGCAAGCTCACGGCATCTACAACCAG
AACCTGCAAGCGGTGCCGCCGACCGGGTCGATTTCCTACATCAACCACTCGACCTCGTCGATCCACCCCATCGTCTCCAA
GGTCGAGATCCGCAAAGAAGGCAAGATCGGTCGCGTCTACTACCCGGCGCCCTACATGACCAACGAGAACCTGGACTACT
ACCAGGATGCCTATGAAATCGGCTACGAGAAGATCATCGACACCTATGCGGCCGCCACTGAGCATGTGGACCAAGGGCTT
TCGTTGACGTTGTTCTTCAAGGACACCGCCACCACCCGCGACGTCAACAAGGCGCAGATTTACGCCTGGCGCAAAGGGAT
CAAAACCCTGTACTACATCAGGCTGCGGCAGATGGCGCTGGAGGGAACCGAGGTCGCCGGCTGCGTGTCCTGCATGCTCT
AG

Protein sequence :
MLNLYDADGKIQFDRDVLAARQFFLQHVNQNTVFFHNQDEKLDYLIRENYYEREVLDQYSRNFVKALLDRAYAKKFRFPT
FLGAFKYYTSYTLKTFDGKRYLERFEDRVVMVALTLASGDATLAEKLVDEIIDGRFQPATPTFLNSGKKQRGEPVSCFLL
RIEDNMESIGRSINSALQLSKRGGGVALLLTNIREHGAPIKNIENQSSGVIPIMKLLEDSFSYANQLGARQGAGAVYLHA
HHPDIYRFLDTKRENADEKIRIKTLSLGVVIPDITFELAKRNDDMYLFSPYDVERVYGVPFADISVTEKYYEMVDDSRIR
KTKIKAREFFQTLAELQFESGYPYIMFEDTVNRANPIEGKITHSNLCSEILQVSTPSLFNDDLSYAKVGKDISCNLGSLN
IARTMDSPDFAQTIEVAIRALTAVSDQTHITSVPSIEQGNNDSHAIGLGQMNLHGYLAREHIFYGSEEGVDFTNIYFYAV
LYHALRASNRIAVERGTRFKGFDQSKYASGEFFDKYTERVWEPKTEKVRQLFADAGIRIPNQDDWQRLKESVQAHGIYNQ
NLQAVPPTGSISYINHSTSSIHPIVSKVEIRKEGKIGRVYYPAPYMTNENLDYYQDAYEIGYEKIIDTYAAATEHVDQGL
SLTLFFKDTATTRDVNKAQIYAWRKGIKTLYYIRLRQMALEGTEVAGCVSCML

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cur_1481 YP_001800875.1 ribonucleotide-diphosphate reductase subunit alpha Not tested Not named Protein 0.0 79