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Name : lysS (MUL_1626) Accession : YP_905597.1 Strain : Mycobacterium ulcerans Agy99 Genome accession: NC_008611 Putative virulence/resistance : Unknown Product : lysyl-tRNA synthetase Function : - COG functional category : J : Translation, ribosomal structure and biogenesis COG ID : COG1190 EC number : 6.1.1.6 Position : 1767497 - 1770790 bp Length : 3294 bp Strand : - Note : catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA DNA sequence : GTGCAGAGTAGGCACATCTCTCGGTATGACTGGGTTCCGGCCGCCGCTGGCTGGGCCGTCGGGGTCATCGCGACCCTGTC ACTGCTGGCCAGCATTTCGCCGCTGGTTCGGTGGATCATCAAGGTTCCCCGAGAATTCATTAACAGTTATCTGTTCAATT TTCCCGACACCAGCTTCGCCTGGTCTTTTGTGCTGGCACTGCTGGCGGCGGCCCTGGCCGCGCGTAAACGGATCGCCTGG CTACTGCTGCTGACCAACGTCGTCTTGGCGGCTTTCCTCAATGCCGCCGACATCGCCGCGGGCGGCAACACCGCGGCCCA GAACTTCGGCGAAAACCTCGGGTTCGAAGTACACGTGGTGGCGATCGTCGTGCTGGTGCTGGGATATCGGCAGTTCTGGA CCAAGGTCCGCAGGGGTGCACTGTTCAAGGCGGCCGCGGTGCTCGTGGCCGGTGGTGCGATCGGAATCCTGGTGTCCTGG GGCCTGGTCGACCTGTTTCCGGGATCCCTCGCGCCGCACGACCGTTTGCCCTACGTGGCCAACCGGGTGATCGGCTTCGC CCTGGCCGATCCCGACCTGTTCACCGGCCGGCCGCACGTCTTCCTCAACGCCATGTTCGGCTTGTTCGGCGCTCTCGCCC TAATTGCGGCCACCATCGTGCTGTTTCAGTCCCAGCGTGCCGACAACGCGTTGACCGGCGAGGACGAGTCGGCCATCCGG GGGTTGCTCGAGCTGTACGGCAACAGCGACTCGCTGGGCTACTTCGCGACCCGTCGCGACAAGTCGGTGATATTCGCCTC CAGCGGCCGTGCCGCCATCACCTATCGGGTCGAAATCGGTGTCTGCCTGGCCAGTGGCGATCCGGTAGGCGACCCGCGGT CGTGGCAGCAAGCGATCGACGCATGGCTACGGCTGTGCCAGACCTATGGTTGGTCGCCCGGTGTGATGGGGGCCAGTTCA CAAGGGGCCAAGGCATATCGCGAGGCGGGTTTGAACGCGCTTGAACTCGGCGACGAGGCGATCTTGGTGCCCGCCGATTT CACGCTGTCCGGCCCCGACATGCGCGGCGTGCGCCAAGCCGTGACCAGGGCACGTCGCGCCGGTCTGACGGTGCGCATCC GGCGTCACCGGGATATCTCCGGCGCCGAAATGGAACAGACGATCGATCGCGCCGACGGCTGGCGCGACACCGAATCCGAG CGCGGCTTCTCGATGGCGCTCGGCCGCCTCGGCGACCCGGCCGACACCGACTGCTTGTTGGTCGAGGCGCTTGACCCCGA CGACCTGGTAGTGGCGATGTTGTCGCTGGTGCCTTGGGGTACCAGCGGGGTCTCCCTGGACCTGATGAGACGTTCTCCGC AATCGCCCAACGGCACCATCGAGCTGATGGTCAGCGAACTGGCGCTGCGCGCCGAAGGCCTCGGCATCAGCCGCATCTCG CTGAACTTCGCGATGTTCCGGTCGGCTTTCGAGCAAGGCGCCCAATTGGGCGCCGGGCCGGTGGCCCGCTTGTGGCGTTG GCTGCTGGTCTTCTTTTCCCGGTGGTGGCAGATCGAGACGCTGTACCGATCCAACCAGAAGTATCAGCCGCAATGGGTGC CCCGCTACGCCTGCTATGAGGACGCGCGGGTGATCCCCAAGGTGGGTGTCGCCTCCGTGATCGCCGAGGGGTTCCTGGTA TTGCCATTCAGCCGGCGCAACAAGGTGCACACCGGTCACCATCCCGCGGTCCCCGAACGGCTGGCGGCCACCGGTTTGTT GCACCATGACGGATCGGCGCCCGACGTCAGCGGGCTGCGGCAATCGGCAATTGCCGACGGCGACGACCCCCAACGTCGGC TGCCCGAGCAAGTCCGGGTGCGGCTGAACAAGTTGAAGAAATTGCGCAGCAGCGGCATTGACGCCTATCCGGTGGGCGAA CCGCCCACTCATACAGTCGCGCAAGCGATGGACGCCGACGACCAGGCGAGCGTGTCGGTATCCGGGCGGATCTTGCGGGT ACGCAACTACGGTGGAGTGCTGTTCGCGCACTTGCGCGACTGGAGCGGCGAGATTCAGGTGCTGCTGGACAACTCGCGAC TGGGGCAGGGCCGCGCCGCGGATTTCAACGCGGCCATAGACCTTGGTGACCTGGTCGAGATGACCGGGCAGATGGGTTCG AGCAAGACCGGAACGCGATCACTGATCGTGCGCCGCTGGCGTCTGATCGGTAAGTGCCTGCGCCCCTTGCCCAACAAGTG GAACGGGTTGACCGATCCCGAAGCCCGAGTGCGGACCCGCTACGTAGACCTCGCTGTCAACGCCGAGTCGCGCACCCTCA TCACGGCCCGCAGCGCGGTGCTGCGCTCCGTCCGAGAAACCCTGTCCGCCAAGGGGTTCATCGAGGTCGAGACACCCATC CTGCAACAGGTACACGGCGGCGCAACGGCCCGCCCGTTCATCACCCACATAAACACCTACTCCATGGACCTGTTCTTGCG CATCGCGCCGGAGCTGTATCTCAAGCGGCTGTGCGTCGGCGGGGTGGAACGGGTCTTCGAACTCGGCCGGGCCTTTCGGA ATGAGGGCGTCGACTTCAGCCACAACCCGGAGTTCACCCTGTTGGAGGCCTATCAAGCGCACGCCGACTACCGGGTATGG ATCGACAGCTGCCGCGAGCTGATCCAAAACGCCGCCCAGGCCGCCAACGGTGCACCCGTCGCGATGCGCCCGGCCGGCGG CGGCCGCCTCGAACCGGTGGGCATCTCGGGGGTCTGGGCGGTCAAGACCGTGCACGACGCGGTGTCAGAGGCCCTCGGTG AGCAGATCGACGCCGATACCGACTTGGCCACCCTGCGCAGGCTGGCTGACGCCGCACGCATCCCCTATCGGGCGCAGTGG GATGCCGGCGCGGTGGTGCTGGAGCTCTACGAACACCTGGTGGAGAGCCGCACCGAGCAGCCGACGTTCTACCTCGACTT CCCGACCTCGGTGTCCCCGCTGACCCGGCCGCATCGCAGCAAGCCCGGAATCGCCGAACGTTGGGACCTGGTAGCCTGGG GCGTCGAGCTTGGTACCGCCTACAGCGAGCTCACCGACCCCGTCGAACAGCGGCTCCGCTTGGAGGAGCAGTCTTTGCTC GCCGCCGGCGGGGATCCCGAAGCGATGCAGCTCGACGAAGACTTCCTGCAGGCCATGGAATACGCGATGCCGCCCACCGG GGGCCTCGGCATGGGCGTCGACCGGGTCGTCATGCTGATCACCGGGCGCAGCATCCGTGAAACGCTCCCGTTCCCGCTGG CCAAGCCGCACTAA Protein sequence : MQSRHISRYDWVPAAAGWAVGVIATLSLLASISPLVRWIIKVPREFINSYLFNFPDTSFAWSFVLALLAAALAARKRIAW LLLLTNVVLAAFLNAADIAAGGNTAAQNFGENLGFEVHVVAIVVLVLGYRQFWTKVRRGALFKAAAVLVAGGAIGILVSW GLVDLFPGSLAPHDRLPYVANRVIGFALADPDLFTGRPHVFLNAMFGLFGALALIAATIVLFQSQRADNALTGEDESAIR GLLELYGNSDSLGYFATRRDKSVIFASSGRAAITYRVEIGVCLASGDPVGDPRSWQQAIDAWLRLCQTYGWSPGVMGASS QGAKAYREAGLNALELGDEAILVPADFTLSGPDMRGVRQAVTRARRAGLTVRIRRHRDISGAEMEQTIDRADGWRDTESE RGFSMALGRLGDPADTDCLLVEALDPDDLVVAMLSLVPWGTSGVSLDLMRRSPQSPNGTIELMVSELALRAEGLGISRIS LNFAMFRSAFEQGAQLGAGPVARLWRWLLVFFSRWWQIETLYRSNQKYQPQWVPRYACYEDARVIPKVGVASVIAEGFLV LPFSRRNKVHTGHHPAVPERLAATGLLHHDGSAPDVSGLRQSAIADGDDPQRRLPEQVRVRLNKLKKLRSSGIDAYPVGE PPTHTVAQAMDADDQASVSVSGRILRVRNYGGVLFAHLRDWSGEIQVLLDNSRLGQGRAADFNAAIDLGDLVEMTGQMGS SKTGTRSLIVRRWRLIGKCLRPLPNKWNGLTDPEARVRTRYVDLAVNAESRTLITARSAVLRSVRETLSAKGFIEVETPI LQQVHGGATARPFITHINTYSMDLFLRIAPELYLKRLCVGGVERVFELGRAFRNEGVDFSHNPEFTLLEAYQAHADYRVW IDSCRELIQNAAQAANGAPVAMRPAGGGRLEPVGISGVWAVKTVHDAVSEALGEQIDADTDLATLRRLADAARIPYRAQW DAGAVVLELYEHLVESRTEQPTFYLDFPTSVSPLTRPHRSKPGIAERWDLVAWGVELGTAYSELTDPVEQRLRLEEQSLL AAGGDPEAMQLDEDFLQAMEYAMPPTGGLGMGVDRVVMLITGRSIRETLPFPLAKPH |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| lysX | YP_003784331.1 | lysyl-tRNA synthetase | Not tested | PiCp 7 | Protein | 3e-153 | 44 |
| lysS1 | YP_005686365.1 | lysyl-tRNA synthetase | Not tested | PiCp 7 | Protein | 3e-153 | 44 |
| lysS1 | YP_005682181.1 | lysyl-tRNA synthetase | Not tested | PiCp 7 | Protein | 5e-153 | 44 |
| lysS1 | YP_005684273.1 | lysyl-tRNA synthetase | Not tested | PiCp 7 | Protein | 3e-153 | 44 |
