Gene Information

Name : pykA (MUL_1598)
Accession : YP_905574.1
Strain : Mycobacterium ulcerans Agy99
Genome accession: NC_008611
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 1731548 - 1732966 bp
Length : 1419 bp
Strand : +
Note : catalyzes the formation of phosphoenolpyruvate from pyruvate

DNA sequence :
GTGACTAGACGCGGAAAGATCGTCTGCACCCTCGGGCCGGCTACGCAACAGGACGACTTGGTCAAAGAGCTGGTCGAAGC
CGGAATGGACGTCGCCCGAATGAACTTCAGCCACGGCGACTACGCGGATCACGAAGCCGCATATGAACGCGTGCGTGCTG
CCTCTGACGCCACGGGGCGTGCGGTCGGCGTGCTCGCCGATCTGCAAGGCCCGAAGATCAGGTTGGGCCGCTTCGCTGAT
GGGCCGACCTATTGGGCTGACGGGGACACGGTCCGGATCACGGTCGAGGAGTGTGAAGGGTGCCGTGACCGGGTATCCAC
CACCTACAAGAGGCTGGCCCAGGATGCGGTAGCCGGTGACCGAGTGCTCGTTGATGACGGCAAGGTCGGATTGATCGTCG
ATCACATCGACGGCAACGACGTGGTCTGCACAGTCGTAGAAGGCGGCCCGGTCAGCAACAACAAGGGAATCTCCCTGCCG
GGGATGAATGTATCTGCGCCGGCGCTATCGGAGAAAGACATCGACGACCTCACGTTCGCGCTCAACCTGGGTGTCGACAT
GGTCGCGCTGTCCTTCGTGCGGTCGCCTTCGGACGTGGAACTCGTGCATGAGGTGATGGACCGGATCGGCCGGCGAGTTC
CGGTGATCGCGAAGCTGGAAAAGCCCGAAGCGATCGACAATCTCGAAGCCATCGTGTTGGCATTCGACGCCGTCATGGTG
GCCCGCGGCGACCTGGGGGTAGAGCTGCCGCTGGAAGAGGTCCCGCTGGTACAGAAGCGGGCCATCCAGATCGCCCGGGA
GAACGCCAAACCGGTGATCGTGGCGACCCAGATGCTCGACTCGATGATCGAGAACTCGCGGCCCACCCGTGCCGAGGCCT
CTGACGTCGCCAACGCCGTGCTTGACGGCGCCGATGCCCTGATGCTGTCCGGTGAGACCTCGGTGGGCAAGTACCCACTT
GCTGCGGTCCGGACGATGTCGCGCATCGTCTGCGCGGTTGAAGAGAACTCGACGGCGGCCCCGCCGTTGACCCATGTGCC
GCGCACCAAGCGGGGAGTGATCTCCTATGCGGCCCGCGACATCGGTGAACGACTCGACGCCAAGGCGTTGGTCGCCTTCA
CTCAGTCCGGCGATACCGTGCGACGGCTTGCTCGGCTGCATACCCCATTGCCGCTGCTGGCCTTCACCGCTTGGCCCGAG
GTGCGCAGTCAGCTCGCGATGACCTGGGGCACCGAGACTTTCATCGTCCCGGAGATGGACTCGACTGACGGCATGATTCG
GCAGGTCGACAAATCGCTGCTAGAACTCGGCCGCTACAAGCGTGGTGATCTGGTGGTCATCGTCGCGGGTGCACCGCCGG
GGACCGTGGGTTCGACCAATCTGATTCACGTGCACCGGATCGGTGAGGACGACGTCTAA

Protein sequence :
MTRRGKIVCTLGPATQQDDLVKELVEAGMDVARMNFSHGDYADHEAAYERVRAASDATGRAVGVLADLQGPKIRLGRFAD
GPTYWADGDTVRITVEECEGCRDRVSTTYKRLAQDAVAGDRVLVDDGKVGLIVDHIDGNDVVCTVVEGGPVSNNKGISLP
GMNVSAPALSEKDIDDLTFALNLGVDMVALSFVRSPSDVELVHEVMDRIGRRVPVIAKLEKPEAIDNLEAIVLAFDAVMV
ARGDLGVELPLEEVPLVQKRAIQIARENAKPVIVATQMLDSMIENSRPTRAEASDVANAVLDGADALMLSGETSVGKYPL
AAVRTMSRIVCAVEENSTAAPPLTHVPRTKRGVISYAARDIGERLDAKALVAFTQSGDTVRRLARLHTPLPLLAFTAWPE
VRSQLAMTWGTETFIVPEMDSTDGMIRQVDKSLLELGRYKRGDLVVIVAGAPPGTVGSTNLIHVHRIGEDDV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 2e-70 41
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 1e-70 41
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 1e-70 41
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 3e-70 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
pykA YP_905574.1 pyruvate kinase VFG0479 Protein 5e-71 41