Gene Information

Name : guaA (Rmag_0914)
Accession : YP_904098.1
Strain : Candidatus Ruthia magnifica Cm
Genome accession: NC_008610
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 979196 - 980761 bp
Length : 1566 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGATGAACAATATTCACCTTGATAAAATCCTTATTCTTGATTTTGGTTCTCAATATACCCAGCTTATTGCCCGTCGTGT
GCGTGAAATTGGTGTTTATTGTGAATTATTTCCCTATGATGTAGATAGTGAATTTATTAAAAAGCTCAATCCTAAAGGTA
TCATTCTTTCAGGTGGTCCTGACACAGTCACACTTGATAATGCTGCCAAAGCACCAAGTATTATATTTGATCTCAACATA
CCGATACTGGGTATTTGTTATGGCATGCAAACTATGGCGATACAACTTGGTGGTCGTGCCACTTCAGCCAACAAACATGA
ATATGGTTTTGCCAAAGTTCGTGTTCGCAACCACTCACCATTACTAAGTGACATTAGTGATGAAGGTCATGGTTTATTAG
ATGTATGGATGAGTCACGGAATTGAGGTAGAACAATTGCCAAATGGATTTAAACTAATTGCTTCTACAGATAACTGTAAT
ATAGCAGGGTTTGCTAATGTAGAAAAACATTATTATGGCTTACAATTTCACCCAGAGGTTACTCATACCAAACAAGGTGA
ACGCATTTTAGAACGCTTTATCAGCGGTATTTGTCAATGTGAAAAAAACTGGACAACGGACAATATCATCGCTAAATTAG
TACAAAACCTTAAAGATCAAATTGGCAATGCTAATATTTTATTAGGACTATCTGGTGGTGTAGATTCCTTAGTAGTTGCC
GTACTTTTGCAACAAGCAGTGGGTAAGCAACTCACTTGTGTATTTGTTGATAATGGCCTTTTACGTTTCAATGAAGGAAA
TGAAGTAATGCAAATCTTTGCACAAAATATGGACATGAAAGTCATACGTGCTAATGCTCATAAAAAATTCTATGACGCAT
TATTAAATGAAAATGAGCCTGAGGCAAAACGCAAAATTATTGGCCGTGCATTTATTGAAGTGTTTGAAGAAGAAGCTAAA
AAACTCGATAACATCCAGTTTTTAGCTCAAGGTACGATTTATCCAGATGTTATTGAATCAGCAGACGCAAAATATGGCAA
AGCTAAACTTATTAAATCACACCATAATGTTGGTGGCTTACCAAACGATTTACAATTCAAATTAGTGGAACCTCTAAAAG
AATTATTCAAAGACGAAGTGCGTAAAATTAGCGTTAAACTAAGTATCCCACCACATATTATTTATCGCCATCCATTCCCA
GGTCCTGGCCTAGGTGTACGTATTCTAGGGCAAGTGAAACAAGAATACGCCAATATTTTAAGACAAGCTGATGCTATTTT
CATGGATGAGTTACATAAAAACAATTTATACGACACAGTCAATCAAGCCTTTGCTGTATTCCTACCTATTAAATCAGTTG
GCATTACTGGAGATGAGCGTCGTTATGACTACGTTATTGCATTACGTGCTGTTGAAACCATTGATTTTATGACAGCTCGC
TGGGCAAGATTGCCGTATGATTTTCTAGATTTAGTATCTAACCGAATCATGAATGAAATCTCTCGTATTTCACGTGTAGT
TTATGACGTTTCTGGGAAACCACCAGCAACCATTGAATGGGAATAA

Protein sequence :
MMNNIHLDKILILDFGSQYTQLIARRVREIGVYCELFPYDVDSEFIKKLNPKGIILSGGPDTVTLDNAAKAPSIIFDLNI
PILGICYGMQTMAIQLGGRATSANKHEYGFAKVRVRNHSPLLSDISDEGHGLLDVWMSHGIEVEQLPNGFKLIASTDNCN
IAGFANVEKHYYGLQFHPEVTHTKQGERILERFISGICQCEKNWTTDNIIAKLVQNLKDQIGNANILLGLSGGVDSLVVA
VLLQQAVGKQLTCVFVDNGLLRFNEGNEVMQIFAQNMDMKVIRANAHKKFYDALLNENEPEAKRKIIGRAFIEVFEEEAK
KLDNIQFLAQGTIYPDVIESADAKYGKAKLIKSHHNVGGLPNDLQFKLVEPLKELFKDEVRKISVKLSIPPHIIYRHPFP
GPGLGVRILGQVKQEYANILRQADAIFMDELHKNNLYDTVNQAFAVFLPIKSVGITGDERRYDYVIALRAVETIDFMTAR
WARLPYDFLDLVSNRIMNEISRISRVVYDVSGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 5e-118 48
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 4e-118 48
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 3e-118 48
guaA NP_938969.1 GMP synthase Not tested Not named Protein 3e-105 46