Gene Information

Name : thyA (FTN_1248)
Accession : YP_898883.1
Strain : Francisella novicida U112
Genome accession: NC_008601
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 1315576 - 1316400 bp
Length : 825 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGCGAGAATATCTAAATTTCCTTAAGTATATCAAAGAAAATGGCGTTTTAAAGGGTGATAGAACCGGTACTGGAACAAG
AAGTATCTTTGGCTATCAAATGCGTTTTGATCTTCAAAAAGGCTTCCCATTAGTAACTACAAAAAAAATTCATATTCCTA
GTGTTGTTCATGAATTATTATGGTTTTTAAGTGGTAGTACAAATATCAAATATCTTAATGATAACAATGTTAGAATTTGG
AATGAGTGGGCAACCGTAGATGGCGAACTTGGTCCTATTTATGGCAAGCAGTGGCGTGATTTTAACGGTCAAGGTATAGA
TCAAATTGCCGATGTAATTCAGATGCTAAAAACAAACCCAAACTCACGTAGGATTCTAGTTTCAGCGTGGAATCCATGTG
TTGTACCATCAGAAAAAATCTCTCCACAAGAAAATGTTGTAAAAGGTAATTCAGCCCTACCACCATGCCATGCAATGTTT
CAGTTCTATGTGGCAAATAATAAACTATCATGCATGCTTACGCAAAGAAGTGCTGATGCTTTTCTTGGAGTACCATTTAA
CATTGCAAGTTATTCACTACTGACACATATGGTTGCACAACAATGTAATCTTGATGTTGGTGAGTTCATCTGGTCAGGTG
GTGATTGTCATATTTACAATAATCATATTGAGCAAGTCAATGAACAGCTTAGTCGTGAGCCTTTAGCTTTACCAACACTA
AAGATTTTAAGAAAACCAAACTCCATCTTTGATTATAAATACGAAGATTTTGAATTTGAGAACTATAACCATCACCCTGC
CATCAAAGCAAAAATATCTGTATAA

Protein sequence :
MREYLNFLKYIKENGVLKGDRTGTGTRSIFGYQMRFDLQKGFPLVTTKKIHIPSVVHELLWFLSGSTNIKYLNDNNVRIW
NEWATVDGELGPIYGKQWRDFNGQGIDQIADVIQMLKTNPNSRRILVSAWNPCVVPSEKISPQENVVKGNSALPPCHAMF
QFYVANNKLSCMLTQRSADAFLGVPFNIASYSLLTHMVAQQCNLDVGEFIWSGGDCHIYNNHIEQVNEQLSREPLALPTL
KILRKPNSIFDYKYEDFEFENYNHHPAIKAKISV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 2e-74 59
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 4e-48 45