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Name : leuS (MSMEG_6917) Accession : YP_891113.1 Strain : Mycobacterium smegmatis MC2 155 Genome accession: NC_008596 Putative virulence/resistance : Unknown Product : leucyl-tRNA synthetase Function : - COG functional category : J : Translation, ribosomal structure and biogenesis COG ID : COG0495 EC number : 6.1.1.4 Position : 6959072 - 6961933 bp Length : 2862 bp Strand : - Note : leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl DNA sequence : GTGACCGAACCCGCAACCACGCCGACAACACCCGATGAGCAGATCCCGCGTCATCGCTACAACGCGGATCTCGCGGGGCA GATCGAGCGGGCGTGGCAGGAGACGTGGTCGGACCGCGGCACGTTCAACGTCGCCAATCCCGTGGGGTCACTCGCGCCGA CGGACGGCTCGGATGTTCCTGCCGACAAGATGTTCGTCCAGGACATGTTCCCGTACCCGTCGGGCGACGGTCTGCACGTC GGGCACCCGCTCGGCTACATCGCGACAGACGTCTACGCGCGCTACTACCGCATGCTCGGCCGCAACGTGTTGCACGCGCT GGGGTTCGATGCCTTCGGCCTGCCCGCCGAGCAGTACGCGGTGCAGACCGGGACGCATCCGCGCACGCGCACCGAGGCCA ACATCGTCAACTTCCGCAGGCAGCTGGGCCGGCTGGGGCTGGGCCACGACACGCGCCGCAGCTTCTCCACCACCGACGTC GACTACTACAAGTGGACGCAGTGGATCTTCCTGCAGATCTACAACGCCTGGTTCGACCGCGACCAGAACAAGGCCCGCCG CATCAGCGAGCTGGTCGAGGAGTTCGAATCGGGTAAGCGCACGCTCGACGACGGCCGCAACTGGGCCGATCTGTCCAAGG GTGAGCGCGCCGATGTGATCGACGGTTACCGCTTGGTGTACCGCGCCGACTCGATGGTGAACTGGTGCCCCGGTCTGGGC ACCGTGCTGGCCAACGAGGAGGTGACCTCCGAGGGCCGCAGCGACCGCGGCAACTTCCCGGTGTTCCGGAAGCGGTTGCG CCAGTGGATGATGCGCATCACCGCGTACTCCGACAGGCTCCTCGAGGATCTCGACGTGCTGGATTGGCCCGAGAAGGTCA AGACCATGCAGCGCAACTGGATCGGCCGCTCGACGGGTGCCTCGGTGCTGTTCGCGACCGCGGCCGACGACATCGAGGTG TTCACCACGCGTCCCGATACGTTGTTCGGCGCAACGTATCTGGTGTTGGCCCCCGAGCACGATCTGGTCGACACGCTGGT GACCGACGCGTGGCCCGACGGCACCGACGAGCGCTGGACCTACGGCGCGGCGACCCCGCGCGAGGCCGTCGCGGCCTACC GCACGGACATCGCCGCGAAGTCGGATCTGGAGCGCCAGGAGAACAAGACCAAGACCGGTGTGTTCCTGGGTGCCTACGCG ACCAATCCCGCTGACGGCAAACAGGTTCCGATCTTCATCGCCGACTACGTGCTGGCCGGCTACGGCACCGGCGCCATCAT GGCGGTGCCCGGCGGCGATCAGCGTGACTGGGATTTCGCCAAGGAGTTCGGCCTGCCCATCATCGAGGTGGTGACCGGTG GTGACATCTCGGAGGCCGCCTACGCGGGCGACGGCACCATGGTCAACTCGGGCTTCCTCGACGGCATGGATGTGGCGTCG GCCAAGGAGGCCATCATCGCCCGTCTCGAGGCCGACGGCCGCGGGAAGCGCCGCGTCGAGTACAAGCTGCGTGACTGGCT GTTCGCCCGCCAGCGCTACTGGGGTGAGCCGTTCCCCATTGTCTACGACGCCGACGGACGTGCCCACCCGCTGCCGGAAT CTGCTCTGCCCGTTGAGCTTCCGGACGTTCCCGACTACTCGCCGGTGCTGTTCGACCCGGACGACGCCGACAGCGAGCCC TCGCCGCCGCTGAACAAGGCCACCGAATGGGTCCACGTCGAACTCGACCTCGGTGACGGTCTGCAGTCCTACACGCGTGA CACCAATGTCATGCCGCAGTGGGCCGGCAGCTCGTGGTACGAGCTGCGCTACACCGACCCGCACAATCCGGATGAGATGT GCGCCAAGGAGAACGAGGCGTACTGGATGGGGCCGCGCCCCGACGAGCACGGCCCGGAGGATCCGGGCGGTGTCGACCTG TACGTCGGCGGCGTGGAACACGCTGTGCTGCACCTGCTGTACTCGCGGTTCTGGCACAAGGTGCTCTACGACCTGGGTTA CGTCAGCTCGCGTGAGCCGTACCGGCGCCTGGTCAACCAGGGCTACATCCAGGCCTTCGCCTACACCGACTCGCGCGGCA CCTATGTGCCCGCCGCCGAGGTGATCGAGCGGGACGGCAAGTTCTTCTGGCCCGGTCCCGATGGTGAAATAGAGGTGAAT CAGGAGTTCGGCAAGATCGGCAAGAGCCTGAAGAACTCGGTGTCGCCCGACGAGATCTGCGACAACTACGGCGCCGACAC GCTGCGCGTGTACGAGATGTCGATGGGCCCGCTCGAGGCGTCGCGGCCGTGGGCCACCAAGGACGTCGTCGGTGCGCACC GCTTCCTGCAGCGTGTGTGGCGCGTCGTGATCGACGAGACCTCGGGCAACGTGCGTGTCGTCGAGCACGAGGCACTCAGC GACGAGACGCTGCGCCTGCTGCACCGCACGATCGAAGGTGTGCGCGAAGACTATGCGGCCCTTCGCAACAACACCGCGGC CGCCAAGCTCATCGAGTACACCAACCACCTCACCAAGGAGGGTGTGGCGGCGCGCGCCGCGATCGAACCACTGGTGCTGA TGGTCGCGCCGCTGGCGCCGCACCTCGCCGAGGAACTGTGGAAGCGGCTGGGCCACGACACCTCGCTGGCACACGGACCT TTCCCCGAGGCCGACCCGCAGTACCTGGTGGAGGACACCATCGAGTTCCCCGTCCAGGTCAACGGCAAGGTGCGCGGCAA GATCGTCGTGGCGGCCGACGCGGACAAGGCCGCGCTCGAGGCCGCGGCCCTGGCCGACGAGAAGGTGCAGGCGTTCCTGG CCGGGGCCACGCCCAAGAAGGTCATCGTCGTTCCGGGCCGGCTGGTCAACCTGGTCGTCTAG Protein sequence : MTEPATTPTTPDEQIPRHRYNADLAGQIERAWQETWSDRGTFNVANPVGSLAPTDGSDVPADKMFVQDMFPYPSGDGLHV GHPLGYIATDVYARYYRMLGRNVLHALGFDAFGLPAEQYAVQTGTHPRTRTEANIVNFRRQLGRLGLGHDTRRSFSTTDV DYYKWTQWIFLQIYNAWFDRDQNKARRISELVEEFESGKRTLDDGRNWADLSKGERADVIDGYRLVYRADSMVNWCPGLG TVLANEEVTSEGRSDRGNFPVFRKRLRQWMMRITAYSDRLLEDLDVLDWPEKVKTMQRNWIGRSTGASVLFATAADDIEV FTTRPDTLFGATYLVLAPEHDLVDTLVTDAWPDGTDERWTYGAATPREAVAAYRTDIAAKSDLERQENKTKTGVFLGAYA TNPADGKQVPIFIADYVLAGYGTGAIMAVPGGDQRDWDFAKEFGLPIIEVVTGGDISEAAYAGDGTMVNSGFLDGMDVAS AKEAIIARLEADGRGKRRVEYKLRDWLFARQRYWGEPFPIVYDADGRAHPLPESALPVELPDVPDYSPVLFDPDDADSEP SPPLNKATEWVHVELDLGDGLQSYTRDTNVMPQWAGSSWYELRYTDPHNPDEMCAKENEAYWMGPRPDEHGPEDPGGVDL YVGGVEHAVLHLLYSRFWHKVLYDLGYVSSREPYRRLVNQGYIQAFAYTDSRGTYVPAAEVIERDGKFFWPGPDGEIEVN QEFGKIGKSLKNSVSPDEICDNYGADTLRVYEMSMGPLEASRPWATKDVVGAHRFLQRVWRVVIDETSGNVRVVEHEALS DETLRLLHRTIEGVREDYAALRNNTAAAKLIEYTNHLTKEGVAARAAIEPLVLMVAPLAPHLAEELWKRLGHDTSLAHGP FPEADPQYLVEDTIEFPVQVNGKVRGKIVVAADADKAALEAAALADEKVQAFLAGATPKKVIVVPGRLVNLVV |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| leuS | YP_281511.2 | leucyl-tRNA synthetase | Not tested | Not named | Protein | 2e-151 | 49 |
