Gene Information

Name : MSMEG_6091 (MSMEG_6091)
Accession : YP_890312.1
Strain : Mycobacterium smegmatis MC2 155
Genome accession: NC_008596
Putative virulence/resistance : Virulence
Product : negative regulator of genetic competence ClpC/mecB
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 6152971 - 6155517 bp
Length : 2547 bp
Strand : -
Note : identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728

DNA sequence :
ATGTTTGAGAGATTTACCGACCGCGCCCGCAGGGTCGTCGTCCTGGCTCAAGAAGAAGCCCGGATGCTCAACCACAACTA
CATCGGCACCGAGCACATCCTTTTGGGACTTATTCATGAGGGCGAGGGTGTAGCGGCCAAGTCGCTCGAGTCGCTCGGGA
TCTCGCTGGAAGGCGTCCGCAGCCAGGTCGAGGAGATCATCGGCCAGGGCCAGCAGGCGCCGTCGGGCCACATCCCGTTC
ACGCCTCGCGCCAAGAAGGTGCTCGAGCTGAGCCTGCGCGAAGCGCTCCAGCTCGGCCACAACTACATCGGCACCGAGCA
CATCCTGCTCGGCCTGATCCGTGAGGGCGAAGGCGTCGCGGCCCAGGTGCTCGTGAAGCTGGGCGCCGAGCTGACGCGGG
TGCGCCAGCAGGTCATCCAGCTGCTGAGCGGCTACCAGGGCAAGGAAGCGGCAGAAGCCGGGACCGGCGGCCGTGGTGGC
GAGTCGGGCAACCCGTCGACCTCGCTCGTGCTCGACCAGTTCGGCCGCAACCTGACCGCGGCCGCGATGGAGGGCAAGCT
CGATCCGGTCATCGGCCGCGAGAAGGAAATCGAGCGGGTCATGCAGGTGCTGAGCCGGCGCACCAAGAACAACCCGGTGC
TGATCGGCGAGCCCGGCGTCGGCAAGACCGCCGTCGTCGAGGGCCTGGCGCAGGCCATCGTGCACGGCGAGGTCCCCGAG
ACGCTCAAGGACAAGCAGCTCTACACCCTCGACCTGGGCTCCCTGGTCGCGGGCAGCCGCTACCGCGGTGACTTCGAGGA
ACGCCTCAAGAAGGTGCTCAAGGAGATCAACACCCGCGGCGACATCATCCTGTTCATCGACGAGCTGCACACGCTCGTCG
GCGCGGGTGCCGCCGAGGGCGCGATCGACGCCGCGAGCATCCTCAAGCCGAAGCTGGCCCGTGGCGAGCTGCAGACGATC
GGCGCCACCACGCTCGACGAGTACCGCAAGTACATCGAGAAGGACGCCGCCCTGGAGCGCCGGTTCCAGCCGGTGCAGGT
GGGCGAGCCGACCGTCGAGCACACCATCGAGATCCTCAAGGGTCTGCGCGACCGTTACGAGGCGCACCACCGCGTCTCGA
TCACCGACTCCGCGATGGTCGCGGCGGCCACCCTGGCCGACCGCTACATCAACGACCGGTTCCTGCCGGACAAGGCGATC
GACCTGATCGACGAGGCAGGCGCGCGGATGCGCATCCGCCGCATGACCGCTCCGCCAGACCTGCGCGAGTTCGACGAGAA
GATCGCCGACGCGCGCCGGGAGAAGGAGTCCGCGATCGATGCGCAGGACTTCGAGAAGGCCGCGGCTCTGCGCGACAAGG
AGAAGCAGCTCGTCGCGCAGCGTGCCGAGCGTGAGAAGCAGTGGCGTTCGGGTGACCTGGACGTCGTGGCCGAGGTCGAC
GACGAGCAGATCGCCGAGGTGCTGGGGAACTGGACCGGTATCCCCGTGTTCAAGCTGACCGAGGAGGAGACGACTCGGCT
GCTGCGCATGGAGGAGGAGCTGCACAAGCGGATCATCGGCCAGGAGGACGCCGTCAAGGCGGTCAGCAAGGCCATCCGCC
GCACGCGTGCCGGCCTGAAGGATCCCAAGCGCCCGTCCGGCTCGTTCATCTTCGCCGGCCCGTCCGGTGTCGGTAAGACC
GAGCTGTCCAAGGCGCTCGCGAACTTCCTGTTCGGCGACGACGACGCGCTCATCCAGATCGACATGGGCGAGTTCCACGA
CCGCTTCACCGCCTCGCGGCTGTTCGGTGCCCCTCCGGGCTACGTCGGCTACGAGGAGGGCGGTCAGCTCACCGAGAAGG
TGCGCCGCAAGCCGTTCAGCGTCGTGCTGTTCGACGAGATCGAGAAGGCCCACCAGGAGATCTACAACAGCCTCCTGCAG
GTCCTCGAGGACGGTCGCCTGACCGACGGCCAGGGTCGCACGGTGGACTTCAAGAACACGGTGCTGATCTTCACGTCGAA
CCTCGGCACGTCCGACATCTCGAAGGCCGTCGGCCTGGGCTTCAGCCAGGGCGGCAGCGAGAACAACTACGAGCGGATGA
AGCAGAAGGTTCACGACGAACTGAAGAAGCATTTCCGTCCGGAGTTCCTCAACCGCATCGACGACATCATCGTCTTCCAC
CAGCTGACGCAGGACGAGATCATCCAGATGGTCGACCTGATGATCGGCCGGGTGTCCAACCAGCTCAAGACCAAGGACAT
GGCTCTGGAGCTCTCGGACAAGGCGAAGGCGTTGCTGGCCAAGCGCGGCTTCGATCCGGTACTGGGCGCGCGCCCGCTGC
GCCGCACGATCCAGCGCGAGATCGAGGACCAGCTGTCGGAGAAGATCCTGTTCGAGGAGATCGGCCCCGGTCAGCTGGTG
ACGGTCGACGTCGAAGGCTGGGACGGCGAAGGCCAGGGCGAGGACGCCAAGTTCACCTTCTCGGGTGGACCCAAGCGCGC
CGAGACCGCCGAGCCCGATCTGGCCGGTGCCGGAGCCGCCGGCGCCCCGACCGCAGGCACGGAGTGA

Protein sequence :
MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKSLESLGISLEGVRSQVEEIIGQGQQAPSGHIPF
TPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVAAQVLVKLGAELTRVRQQVIQLLSGYQGKEAAEAGTGGRGG
ESGNPSTSLVLDQFGRNLTAAAMEGKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVHGEVPE
TLKDKQLYTLDLGSLVAGSRYRGDFEERLKKVLKEINTRGDIILFIDELHTLVGAGAAEGAIDAASILKPKLARGELQTI
GATTLDEYRKYIEKDAALERRFQPVQVGEPTVEHTIEILKGLRDRYEAHHRVSITDSAMVAAATLADRYINDRFLPDKAI
DLIDEAGARMRIRRMTAPPDLREFDEKIADARREKESAIDAQDFEKAAALRDKEKQLVAQRAEREKQWRSGDLDVVAEVD
DEQIAEVLGNWTGIPVFKLTEEETTRLLRMEEELHKRIIGQEDAVKAVSKAIRRTRAGLKDPKRPSGSFIFAGPSGVGKT
ELSKALANFLFGDDDALIQIDMGEFHDRFTASRLFGAPPGYVGYEEGGQLTEKVRRKPFSVVLFDEIEKAHQEIYNSLLQ
VLEDGRLTDGQGRTVDFKNTVLIFTSNLGTSDISKAVGLGFSQGGSENNYERMKQKVHDELKKHFRPEFLNRIDDIIVFH
QLTQDEIIQMVDLMIGRVSNQLKTKDMALELSDKAKALLAKRGFDPVLGARPLRRTIQREIEDQLSEKILFEEIGPGQLV
TVDVEGWDGEGQGEDAKFTFSGGPKRAETAEPDLAGAGAAGAPTAGTE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 0.0 82

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
MSMEG_6091 YP_890312.1 negative regulator of genetic competence ClpC/mecB VFG0079 Protein 0.0 60
MSMEG_6091 YP_890312.1 negative regulator of genetic competence ClpC/mecB VFG0080 Protein 1e-144 51