Gene Information

Name : prrA (MSMEG_5662)
Accession : YP_889895.1
Strain : Mycobacterium smegmatis MC2 155
Genome accession: NC_008596
Putative virulence/resistance : Virulence
Product : DNA-binding response regulator PrrA
Function : -
COG functional category : T : Signal transduction mechanisms
COG ID : COG0745
EC number : -
Position : 5755451 - 5756161 bp
Length : 711 bp
Strand : +
Note : identified by similarity to SP:Q10531; match to protein family HMM PF00072; match to protein family HMM PF00486

DNA sequence : 
ATGGACAGTACTACCAGCGGCATGGCCTCGCCGAGGGTGCTTGTGGTGGATGACGACCCCGACGTGCTCGCCTCACTCGA
ACGCGGGCTGCGGCTGTCCGGATTCGACGTGTCGACAGCCGTGGACGGGGCCGAGGCGCTGCGCAGCGCCACCGAGACGC
GCCCCGACGCCATCGTGCTCGACATCAACATGCCCGTCCTCGACGGTGTCAGCGTGGTGACCGCGCTCCGCGCCATGGAC
AACGACGTGCCGGTGTGCGTGTTGTCCGCGCGCAGCAGTGTCGACGACCGCGTCGCGGGGCTCGAAGCCGGCGCCGACGA
CTACCTGGTGAAACCGTTCGTGCTGGCCGAACTCGTGGCGCGGGTCAAGGCGCTGCTGCGCCGCCGCGGCTCGTCGGCCA
CGTTCTCGTCGGAGACCATCCAGGTCGGCCCGCTCGAGGTGGACATCCCGGGCCGTCGCGCGCGCGTCAACGGCGTCGAC
GTCGACCTGACCAAGCGCGAGTTCGACCTGCTCGCCGTGCTGGCCGAGCACAAGACCGCGGTGCTCTCGCGCGCCCAGCT
GCTCGAGCTGGTGTGGGGCTACGACTTCGCGGCCGACACCAACGTCGTCGACGTGTTCATCGGCTACCTGCGCCGGAAGC
TCGAAGCCGGTGGCGCGCCCCGATTGCTGCACACCGTGCGAGGCGTCGGTTTCGTCCTGCGGACCCAGTAG

Protein sequence : 
MDSTTSGMASPRVLVVDDDPDVLASLERGLRLSGFDVSTAVDGAEALRSATETRPDAIVLDINMPVLDGVSVVTALRAMD
NDVPVCVLSARSSVDDRVAGLEAGADDYLVKPFVLAELVARVKALLRRRGSSATFSSETIQVGPLEVDIPGRRARVNGVD
VDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFAADTNVVDVFIGYLRRKLEAGGAPRLLHTVRGVGFVLRTQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
copR NP_460069.2 transcriptional regulatory protein YedW Not tested SPI-5 Protein 1e-25 42
copR AAC33719.1 regulatory protein CopR Not tested SPI-5 Protein 6e-25 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
prrA YP_889895.1 DNA-binding response regulator PrrA BAC0083 Protein 7e-32 46
prrA YP_889895.1 DNA-binding response regulator PrrA BAC0125 Protein 2e-30 45
prrA YP_889895.1 DNA-binding response regulator PrrA BAC0197 Protein 6e-25 44
prrA YP_889895.1 DNA-binding response regulator PrrA AE000516.2.gene3505. Protein 1e-28 44
prrA YP_889895.1 DNA-binding response regulator PrrA NC_010079.5776364.p0 Protein 2e-32 42
prrA YP_889895.1 DNA-binding response regulator PrrA NC_002952.2859858.p0 Protein 2e-32 42
prrA YP_889895.1 DNA-binding response regulator PrrA NC_007622.3794948.p0 Protein 2e-32 42
prrA YP_889895.1 DNA-binding response regulator PrrA NC_003923.1003417.p0 Protein 2e-32 42
prrA YP_889895.1 DNA-binding response regulator PrrA NC_013450.8614146.p0 Protein 2e-32 42
prrA YP_889895.1 DNA-binding response regulator PrrA NC_002951.3238224.p0 Protein 2e-32 42
prrA YP_889895.1 DNA-binding response regulator PrrA NC_007793.3914065.p0 Protein 2e-32 42
prrA YP_889895.1 DNA-binding response regulator PrrA NC_002758.1121390.p0 Protein 2e-32 42
prrA YP_889895.1 DNA-binding response regulator PrrA HE999704.1.gene1528. Protein 3e-31 42
prrA YP_889895.1 DNA-binding response regulator PrrA BAC0111 Protein 7e-27 42
prrA YP_889895.1 DNA-binding response regulator PrrA NC_012469.1.7685629. Protein 1e-27 42
prrA YP_889895.1 DNA-binding response regulator PrrA BAC0638 Protein 5e-24 42
prrA YP_889895.1 DNA-binding response regulator PrrA BAC0308 Protein 3e-27 41
prrA YP_889895.1 DNA-binding response regulator PrrA NC_002952.2859905.p0 Protein 2e-28 41
prrA YP_889895.1 DNA-binding response regulator PrrA NC_002758.1121668.p0 Protein 3e-28 41
prrA YP_889895.1 DNA-binding response regulator PrrA NC_007622.3794472.p0 Protein 2e-28 41
prrA YP_889895.1 DNA-binding response regulator PrrA NC_009641.5332272.p0 Protein 3e-28 41
prrA YP_889895.1 DNA-binding response regulator PrrA NC_013450.8614421.p0 Protein 3e-28 41
prrA YP_889895.1 DNA-binding response regulator PrrA NC_007793.3914279.p0 Protein 3e-28 41
prrA YP_889895.1 DNA-binding response regulator PrrA NC_002745.1124361.p0 Protein 3e-28 41
prrA YP_889895.1 DNA-binding response regulator PrrA NC_009782.5559369.p0 Protein 3e-28 41
prrA YP_889895.1 DNA-binding response regulator PrrA NC_002951.3237708.p0 Protein 3e-28 41
prrA YP_889895.1 DNA-binding response regulator PrrA NC_003923.1003749.p0 Protein 3e-28 41
prrA YP_889895.1 DNA-binding response regulator PrrA HE999704.1.gene2815. Protein 6e-27 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
prrA YP_889895.1 DNA-binding response regulator PrrA VFG1389 Protein 7e-84 94
prrA YP_889895.1 DNA-binding response regulator PrrA VFG1390 Protein 1e-41 50
prrA YP_889895.1 DNA-binding response regulator PrrA VFG1386 Protein 7e-36 45
prrA YP_889895.1 DNA-binding response regulator PrrA VFG0596 Protein 6e-26 42