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Name : lysS (MSMEG_3796) Accession : YP_888089.1 Strain : Mycobacterium smegmatis MC2 155 Genome accession: NC_008596 Putative virulence/resistance : Unknown Product : lysyl-tRNA synthetase Function : - COG functional category : J : Translation, ribosomal structure and biogenesis COG ID : COG1190 EC number : 6.1.1.6 Position : 3863058 - 3866327 bp Length : 3270 bp Strand : + Note : catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA DNA sequence : GTGGCCTGGGTGCCCGCGGCAGCGGGCTGGACCGTCGGCGTCATCGCGACCCTCTCGTTGATCGCCAGCGTCTCGCCTCT CGTGCGCTCGCTCATCCGGGTGCCGCGGGAGTTCGTCAACGACTTCATCTTCAACTTCCCGGACACCAGCTTCGCCTGGG CGTTCGTCCTGGCGCTGCTGGCCGCCGCGCTGGCGGCCCGCAAGCGCATCGCGTGGTGGGTCCTGGTGCTCTACCTGGTG GGTGCCATCGGCTGGAACGTGGGCGATCTCGCGGCGGGCGGCGACACCGTCGCCGACGACATCGGCGAGCTCATCGGCAT CGCCTTCCACGTCGCGGCGATCGTGTTCCTGGTGGTGGCCCGCAAGGAGTTCTGGGCCAAGGTCCGCCGCGGCGCTCTGC TCAAGTCGGCGGCGGTGCTGGTGGCCGGCAACCTGATCGGCATCGTCGTGGCGTGGGGACTGCTGCAGGCGTTCCCGGGC ACCCTTGACCCCGAGTGGCGGTTGCCGTACGCGGTCAACCGGGTCAGCGGGTTCGCGACCGTGCCCACCGAGGTGTTCGA GGGTTACTCGCACACGTTCCTCAACGCGATCTTCGGCCTGTTCGGCGCACTGGCTTTGATGGCCGCGGCGATCGTGCTGT TCCAATCGCAGCGCGCGTCGAACGCGCTCACCGGTGAGGACGAGTCCGCCATCCGGGGGCTGCTCGAGCTCTACGGCAAG AACGACTCCCTCGGCTACTTCGCGACCCGCCGCGACAAGTCGGTGGTGTTCGCGCCGAACGGACGCGCCGCAATCACCTA CCGCGTCGAGGTCGGCGTGTGCCTGGCCAGTGGCGACCCCGTCGGTGACCCCAAGTCGTGGCCGCAGGCCATCGCGGCGT GGTTGCAGTTGTGCCAGGCCTACGGCTGGGCACCCGGCGTGATGGGCGCGAGCCTGGCGGGCGCCGAGGCCTACCGGGCC GCGGGTCTCAACGCGCTGCAACTGGGCGACGAGGCGATCCTGCACCCCGACCGCTTCCGGTTGTCGGGACCCGACATGCG CGCCGTGCGCCAGGCCGTGACCCGCGCGCGCCGGGCAGGCACCTCGGTGCGGATCCGGCGGCACCGCGAACTGTCACCCG AGGAGATGGCCGCGGTGATCCGGCGTGCCGACGCGTGGCGCGACACCGAGACCGAACGCGGCTTCTCGATGGCGCTGGGC CGGCTGGGCGATCCCGCCGACGACGACTGTCTGCTGGTCGAGGCCGTGCAGGGCGATGAGGTGGTGGCGATGCTGTCGCT CGTGCCGTGGGGCAGCAACGGTGTGTCGCTCGACGTCATGCGACGCTCACCGCGGTCGCCCAACGGCACCATCGAGCTGA TGGTCAGCGAGCTGTGCATGCAGGCCGAGGACATCGGCATCAGCCGGATCTCATTGAACTTCGCGATGTTCCGCTCGGCG TTCGAGCAGGGCGCGCAGCTGGGTGCCGGGCCGGTCGCGCGGCTGTGGCGGGCCCTGCTGGTGTTCTTCTCCAAATGGTG GCAGCTGGAGAGCCTGTACCGCTCCAACATGAAGTACCAGCCCGAGTGGGTGCCGCGGTACGCGTGTTACGAGGACGCGC GGCTGGTGCCGCGGGTCGGTGTGGCGTCGGTGATTGCGGAAGGCTTTCTGGTGCTTCCGTTCTCGCGACGCAACAAGCAA CACACCGGCGAGCACATCGCCGCACCCGACACCCTGGTGCAGTCCGGGCGACTGCACCGCGACGGCAGCGCACCCGACGT CACCGGGCTGCAGGGCGAGCTGCCCGACGCCGACGACGAGCCCCGCCTGCCCGAGCAGGTCCGCGTGCGCATGGCCAAAC TCAAGGCGTTGCAGGGCAACGGCGTCGACGCCTACCCCGTGGGGCAACCGCCCAGCCACACCGTCGCTCAGGCCCTTGGC GCCACCGATGGCGAGACGCTGTCGGTGGCCGGCCGTGTGATGCGGATCCGCGACTACGGCGGCGTGCTGTTCGCGCAACT GCGGGACTGGTCGGGTGAGGTCCAATTGCTGTTGGACAACGCCGCACTGACCGAGGGCGAGACCGCGGACTTCACCGCGA CGATCGACCTGGGCGACCTCGTCGAGGTGACCGGTTCGATGGGCTTCAGCCGCAACGGAACCCGCTCGCTGCTGGTCGAG CGCTGGCGACTGATCGGCAAGTGCCTGCGCCCGCTGCCCGACAAGTGGAAGGGCCTCACCGACCAGGAGGCCCGTGTGCG GGCCCGCTATGTCGACCTGGCCGTCAACACCGAGGCGCGCGATCTGATCCGCGCACGCAGCGGCGCGTTGCACGCCATCC GGGAAACCCTGTACTCCAAGGGTTTCCTCGAGGTCGAGACCCCGATCCTGCAGCAAATCCACGGCGGCGCCAACGCCAGG CCGTTCTTGACCCACATCAACGCCTACGACCTGGACCTGTATCTGCGGATCGCACCCGAGCTGTACCTCAAGCGGTTGTG CGTGGGCGGTGTCGAGCGGGTCTTCGAACTGGGCCGCGCGTTCCGCAACGAGGGCGTCGACTTCAGCCACAACCCCGAGT TCACACTCCTGGAGGCCTATCAGGCGCACGCCGACTACAACGTGTGGATCGACGGCTGCCGCGAGCTGATCCAGAACGCG GCACAGGCCGCCAACGGTGCGCAGGTGTTCCTGCGGCCCCGCCCGAACGATCCGGCCGGGACCCTCGAGCCCGTCGACAT CTCCGGGCAGTGGGCCGTCAAGACCGTGCACGACGCGGTCTCCGAGGCGATCGGCGAGCACATCACGCCCGAGACCGAGC TGGGCGAGCTTCGGCGCCTGTGTGATTCGGCCGGTATTCCCTACCTGACGCACTGGGACGCCGGCGCGGTGGTTCTGGAG ATGTACGAGCACCTGGTCGAGGACCGCACCACCGAACCCACGTTCTACAAGGACTTCCCGACGTCGGTGTCGCCGCTGAC CCGGCCGCACCGCAGCATCCCGGGGGTCGCCGAACGCTGGGACCTGGTGGCGTGGGGCGTCGAACTCGGCACGGCCTACA GCGAGCTGACCGATCCGGTCGAGCAGCGCCGCCGCCTGCAGGAGCAGTCCCTGCTTGCGGCCGGTGGTGATCCCGAGGCG ATGGAACTCGACGAGGACTTCCTGCAGGCCATGGAGTACGCCATGCCGCCGACCGGCGGCCTGGGCATGGGCGTGGACCG CGTGGTCATGATGATCACCGGGCGCAGCATCCGTGAGACGCTGCCGTTCCCGCTCGCCAAACCGCGTTAG Protein sequence : MAWVPAAAGWTVGVIATLSLIASVSPLVRSLIRVPREFVNDFIFNFPDTSFAWAFVLALLAAALAARKRIAWWVLVLYLV GAIGWNVGDLAAGGDTVADDIGELIGIAFHVAAIVFLVVARKEFWAKVRRGALLKSAAVLVAGNLIGIVVAWGLLQAFPG TLDPEWRLPYAVNRVSGFATVPTEVFEGYSHTFLNAIFGLFGALALMAAAIVLFQSQRASNALTGEDESAIRGLLELYGK NDSLGYFATRRDKSVVFAPNGRAAITYRVEVGVCLASGDPVGDPKSWPQAIAAWLQLCQAYGWAPGVMGASLAGAEAYRA AGLNALQLGDEAILHPDRFRLSGPDMRAVRQAVTRARRAGTSVRIRRHRELSPEEMAAVIRRADAWRDTETERGFSMALG RLGDPADDDCLLVEAVQGDEVVAMLSLVPWGSNGVSLDVMRRSPRSPNGTIELMVSELCMQAEDIGISRISLNFAMFRSA FEQGAQLGAGPVARLWRALLVFFSKWWQLESLYRSNMKYQPEWVPRYACYEDARLVPRVGVASVIAEGFLVLPFSRRNKQ HTGEHIAAPDTLVQSGRLHRDGSAPDVTGLQGELPDADDEPRLPEQVRVRMAKLKALQGNGVDAYPVGQPPSHTVAQALG ATDGETLSVAGRVMRIRDYGGVLFAQLRDWSGEVQLLLDNAALTEGETADFTATIDLGDLVEVTGSMGFSRNGTRSLLVE RWRLIGKCLRPLPDKWKGLTDQEARVRARYVDLAVNTEARDLIRARSGALHAIRETLYSKGFLEVETPILQQIHGGANAR PFLTHINAYDLDLYLRIAPELYLKRLCVGGVERVFELGRAFRNEGVDFSHNPEFTLLEAYQAHADYNVWIDGCRELIQNA AQAANGAQVFLRPRPNDPAGTLEPVDISGQWAVKTVHDAVSEAIGEHITPETELGELRRLCDSAGIPYLTHWDAGAVVLE MYEHLVEDRTTEPTFYKDFPTSVSPLTRPHRSIPGVAERWDLVAWGVELGTAYSELTDPVEQRRRLQEQSLLAAGGDPEA MELDEDFLQAMEYAMPPTGGLGMGVDRVVMMITGRSIRETLPFPLAKPR |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| lysS1 | YP_005682181.1 | lysyl-tRNA synthetase | Not tested | PiCp 7 | Protein | 5e-160 | 42 |
| lysS1 | YP_005684273.1 | lysyl-tRNA synthetase | Not tested | PiCp 7 | Protein | 3e-160 | 42 |
| lysX | YP_003784331.1 | lysyl-tRNA synthetase | Not tested | PiCp 7 | Protein | 3e-160 | 42 |
| lysS1 | YP_005686365.1 | lysyl-tRNA synthetase | Not tested | PiCp 7 | Protein | 3e-160 | 42 |
