Gene Information

Name : tpx (MSMEG_3479)
Accession : YP_887783.1
Strain : Mycobacterium smegmatis MC2 155
Genome accession: NC_008596
Putative virulence/resistance : Virulence
Product : thiol peroxidase
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG2077
EC number : 1.11.1.-
Position : 3545574 - 3546068 bp
Length : 495 bp
Strand : -
Note : antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein

DNA sequence : 
ATGGCACAGATAACACTGCGTGGTAACCCCATCAACACCGTCGGCGAGCTGCCCGCGGTCGGCTCTTCTGCCCCCGGCTT
CACGCTGACCGGCACCGATCTGGGCGAGGTCACCAACGACCAGTTCAGCGGTAAGTCCGTACTGCTGAACATCTTCCCGT
CGGTCGACACCCCGGTCTGCGCCACCAGTGTCCGCACCTTCAACGAGAAGGCCGCGTCCAGCGGTGCGACCGTCCTGTGC
GTGTCCAAGGATCTGCCGTTCGCGCAGAAGCGCTTCTGCGGCGCCGAGGGCATCGAGAACGTCACGACGGCGTCGGCGTT
CCGCAGCAGCTTCGGCGAGGACTTCGGCATCACCATCGCCGACGGCCCGATGGCCGGCCTGCTCGGGCGCGCCGTGGTCG
TGATCGGCGCCGACGGCAACGTCGTGTACAGCGAGTTGGTGCCGGAGATCGGGCAGGAACCCGACTACGAGGCAGCGCTG
AAAGCGCTCGGCTAG

Protein sequence : 
MAQITLRGNPINTVGELPAVGSSAPGFTLTGTDLGEVTNDQFSGKSVLLNIFPSVDTPVCATSVRTFNEKAASSGATVLC
VSKDLPFAQKRFCGAEGIENVTTASAFRSSFGEDFGITIADGPMAGLLGRAVVVIGADGNVVYSELVPEIGQEPDYEAAL
KALG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tagD AAK20781.1 toxR-activated gene D protein Virulence VPI Protein 2e-35 46
tpx YP_001216305.1 thiol peroxidase Not tested VPI-1 Protein 3e-35 46
tpx NP_230472.1 thiol peroxidase Virulence VPI-1 Protein 3e-35 46
tagD AAK20751.1 toxR-activated gene D protein Virulence VPI Protein 2e-35 46

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
tpx YP_887783.1 thiol peroxidase VFG0087 Protein 9e-36 46