Gene Information

Name : smpB (MSMEG_2091)
Accession : YP_886451.1
Strain : Mycobacterium smegmatis MC2 155
Genome accession: NC_008596
Putative virulence/resistance : Unknown
Product : SsrA-binding protein
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0691
EC number : -
Position : 2167390 - 2167875 bp
Length : 486 bp
Strand : +
Note : binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Ca

DNA sequence :
GTGACCAAGAAGAGCGCCTCCAGCAACAACAAGGTGGTCGCCACCAACCGCAAGGCGCGACACAACTACACGATCCTCGA
CACCTACGAGGCCGGGATCGTGTTGATGGGCACGGAGGTCAAGAGCCTGCGCGAAGGTCAGGCCTCGCTGGCCGACGCGT
TCGCCACGGTCGACGACGGCGAGATCTGGCTGCGCAACGTCCACATCGCCGAATATCACCACGGCACCTGGACCAACCAC
GCGCCGCGGCGCAACCGCAAACTGCTGCTGCACCGCAAGCAGATCGACAACCTCATCGGCAAGATCCGCGACGGCAACCT
CACGCTGGTGCCGCTGTCGATCTACTTCACCGACGGCAAGGTCAAGGTCGAGTTGGCGCTCGCCCGCGGCAAGCAGGCCC
ACGACAAGCGCCAGGACCTCGCCCGTCGAGACGCTCAACGCGAGGTGATCCGCGAGCTGGGCCGCCGGGCCAAGGGCAAG
ATCTGA

Protein sequence :
MTKKSASSNNKVVATNRKARHNYTILDTYEAGIVLMGTEVKSLREGQASLADAFATVDDGEIWLRNVHIAEYHHGTWTNH
APRRNRKLLLHRKQIDNLIGKIRDGNLTLVPLSIYFTDGKVKVELALARGKQAHDKRQDLARRDAQREVIRELGRRAKGK
I

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
smpB YP_001800894.1 SsrA-binding protein Not tested Not named Protein 5e-50 68
unnamed AET14351.1 SsrA-binding protein Not tested SaPI68111 Protein 2e-31 51
smpB NP_230495.1 SsrA-binding protein Not tested VPI-1 Protein 8e-24 42