Gene Information

Name : guaA (MSMEG_1610)
Accession : YP_885988.1
Strain : Mycobacterium smegmatis MC2 155
Genome accession: NC_008596
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1698411 - 1699973 bp
Length : 1563 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
GTGGCATCAGAATCTCCCCGCCCCGTCCTCGTCATCGACTACGGCGCGCAGTACGCCCAGCTGATCGCACGGCGGGTCCG
TGAGGCGCGGGTGTATTCGGAAGTCGTCCCGCACACCGCAGGCGTCGAGGAGATCAAGGCCAAGGATCCCCAGGCCATCG
TGCTGTCGGGCGGACCGGCCAGCGTCTACTCCGAGGGCGCCCCGCAGCTCGATCCCGGGCTGTTCGACCTGGACGTGCCG
GTGTTCGGCATCTGCTACGGCTTCCAGGCCATGGCGCAGGCGCTCGGCGGCACCGTCGAACGCACCGGCACCAGCGAGTT
CGGGCGCACCGAGCTGCAGGTCACCGGTGGCGACCTGCACTCCGAGCTGCCCGCCACGCAGCCGGTGTGGATGAGCCACG
GCGACGCGGTGACCGCGGCGCCCGAGGGCTTCGACGTGGTCGCCTCCAGCGCCGGTGCGCCCGTCGCGGGCTTCGAGAAC
CGCGCGCGCCGCCTGGCGGGTGTGCAATATCACCCCGAGGTGCTGCACTCGCCGCACGGCCAGCAGGTGCTCAGCCGGTT
CCTGCACGATTTCGCCGGGATCGACGCGACGTGGACACCGGCCAACATCGCCGATCAGCTGATCGAGGCCGTGCGTGAGC
AGATCGGTGACGGCCGCGCGATCTGCGGCCTGTCCGGTGGCGTGGACTCGGCTGTCGCCGCGGCGCTGGTCCAGCGTGCG
ATCGGCGACCGGCTGACGTGTGTGTTCGTCGACCATGGCCTGCTGCGCGCGGGCGAGCGCGCCCAGGTGCAGCGCGACTT
CGTCGCCGCGACCGGCGCCAAGCTGGTCACCGTCGACGTCGCCGACCGGTTTTTGGAAGCGCTGACCGGCGTGACCAACC
CCGAGGGCAAGCGCAAGATCATCGGCCGCGAGTTCATCCGGGCGTTCGAGGGCGCGGTGCGTGACCTGGTCGAGGATGAG
GGCAGCGGCGACATCGACTTCCTGGTGCAGGGCACGCTGTACCCCGACGTCGTGGAATCCGGCGGCGGTTCCGGCACGGC
CAACATCAAGAGCCATCACAACGTCGGCGGGCTGCCCGACGATCTGAAGTTCAAGCTCGTCGAGCCGCTGCGGCTGCTGT
TCAAGGACGAGGTCCGCGCGGTGGGCCGTGAACTCGGACTCCCCGAGGAAATCGTTGCGCGCCAACCCTTCCCGGGACCC
GGACTCGGCATCCGCATCGTCGGCGAGGTCACCGCGGAGCGGTTGGAGACGCTGCGCCGTGCCGACGCCATCGCGCGTGA
GGAACTTACGGCCGCCGGCCTGGACAACCAGATCTGGCAGTGCCCGGTGGTGCTGCTGGCCGACGTCCGCTCGGTCGGCG
TGCAGGGCGACGGACGTACGTACGGGCATCCGATCGTGCTGCGTCCGGTGTCCAGCGAGGACGCCATGACCGCCGACTGG
ACGCGCGTGCCTTACGAAGTGCTGGAACGCATTTCGACCCGCATCACCAACGAGGTGCGCGAGGTCAACCGCGTGGTGCT
CGACATCACCAGCAAGCCGCCGGGCACCATCGAGTGGGAGTGA

Protein sequence :
MASESPRPVLVIDYGAQYAQLIARRVREARVYSEVVPHTAGVEEIKAKDPQAIVLSGGPASVYSEGAPQLDPGLFDLDVP
VFGICYGFQAMAQALGGTVERTGTSEFGRTELQVTGGDLHSELPATQPVWMSHGDAVTAAPEGFDVVASSAGAPVAGFEN
RARRLAGVQYHPEVLHSPHGQQVLSRFLHDFAGIDATWTPANIADQLIEAVREQIGDGRAICGLSGGVDSAVAAALVQRA
IGDRLTCVFVDHGLLRAGERAQVQRDFVAATGAKLVTVDVADRFLEALTGVTNPEGKRKIIGREFIRAFEGAVRDLVEDE
GSGDIDFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPDDLKFKLVEPLRLLFKDEVRAVGRELGLPEEIVARQPFPGP
GLGIRIVGEVTAERLETLRRADAIAREELTAAGLDNQIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADW
TRVPYEVLERISTRITNEVREVNRVVLDITSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA NP_938969.1 GMP synthase Not tested Not named Protein 0.0 78
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-133 51
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-133 51
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-133 51