Gene Information

Name : tkt (MAV_3327)
Accession : YP_882509.1
Strain : Mycobacterium avium 104
Genome accession: NC_008595
Putative virulence/resistance : Unknown
Product : transketolase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0021
EC number : 2.2.1.1
Position : 3468366 - 3470465 bp
Length : 2100 bp
Strand : +
Note : catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during expo

DNA sequence :
GTGACGACACTTGAAGAGATCTCTGCGCTGACCCAACCGCACCTTCCCGACGACTGGTCCGAGCTGGACTCGGCCGCCGT
CGACACCATTCGGGTGCTGGCCGCCGACGCGGTGCAAAAGGTGGGCAACGGACATCCCGGGACGGCGATGAGCCTGGCTC
CCCTGGCCTACACGCTGTTTCAGCGGGTGATGCGGCACGACCCCAGCGACACCCACTGGCTGGGCCGGGACCGGTTCGTG
CTGTCAGCCGGGCACAGCAGCCTGACGCTGTACCTGCAGCTGTACCTGGGTGGCTTCGGTCTGGAGCTGTCCGACATCGA
GTCGCTGCGCACCTGGGGCTCCAAGACGCCCGGGCACCCGGAGTTCCGGCACACCAAGGGTGTGGAGATCACCACCGGCC
CGCTGGGCCAGGGCCTGGCCTCCGCGGTGGGCATGGCGATGGCCTCCCGCTACGAGCGCGGGCTGTTCGACCCGGACGCC
GCCGCCGGCACCAGCCCGTTCGACCACTTCATCTACGTGATCGCCTCCGACGGCGACATCGAGGAGGGCGTCACGTCGGA
GGCCTCGTCGCTGGCGGCCGTGCAGCAACTGGGCAATCTGATCGTGTTCTACGACCACAACCAGATCTCCATCGAGGACG
ACACCAACATCGCCCTGTGCGAGGACACCGCCGCCCGCTACGAGGCCTACGGCTGGCACGTGCAGCGCGTCGAGGGTGGC
GAGAACGTCGTCGCCATCGAGGAGGCCATCGCCGCCGCCAAGGCCGTCACCGACCGGCCGTCGTTCATCGAGCTGCGCAC
CATCATCGGCTATCCGGCGCCCAACGCGATGAACACCGGCAAGGCGCACGGCGCGGCGCTGGGCGAGGAGGAGGTGGCCG
CGGTCAAGAAGATCCTCGGCTTCGACCCGGACAAGACGTTCCAGGTGCGCGACAAGGTGATCGCCCACACCCGCAAGCTG
GTCGACCGCGGCCGGGAGGCACACCAGAAGTGGCAGACCGATTTCGACGCCTGGGCGCAGCGCGAGCCCGAGCGCAAGGC
GCTGCTGGAGCGGTTGACGGCCGAGAAGCTGCCCGACGGGTGGGACGCCGACCTGCCGCACTGGGAGCCGGGCTCCGACG
CGATCGCCACCCGCAAGGCCTCCGGCGCGGTGCTCAACGCCGTGGCGCCGAAACTGCCCGAGCTCTGGGGCGGCTCGGCC
GACCTGGCCGAGAGCAACCTCACCACCATCAACAACGCGGATTCCTTTGGGCCCCCGTCGATTTCCACCAAGGAGTTCAC
CGCCTCCTGGTATGGCCGGGTGCTGCATTTCGGTGTCCGCGAACACGCCATGGGGGCGATCCTGTCCGGCATCGTGCTGC
ACGGCCCGACCCGCGCCTACGGCGGCACCTTCCTGCAGTTCTCGGACTACATGCGTCCGGCGGTGCGGCTGGCCTCGCTG
ATGGACATCGACACCATCTACGTGTGGACGCACGATTCCATCGGGCTGGGTGAGGACGGGCCGACGCACCAGCCGATCGA
GCACCTGGCGGCGTTGCGCGCCATCCCCAAGCTGTCGGTGGTGCGTCCGGCCGACGCCAACGAGACCGCCTACGCCTGGC
GCACCATCCTGGCCCGCGGCAACGGCAGCGGCCCGGTCGGATTGGTCCTGACCCGCCAGGGCCTGCCGGTGCTCGAGGGC
ACCGACGCCGACGGTGTCGCCCGGGGCGGCTACATCCTGGGCTCGGACGGCGAGGAGGCCGGCCAGGAGCCCGACGTCAT
CCTGATCGCCACCGGCTCGGAGGTACAGCTGGCCGTCGAGGCGCAGAAGTTGTTGGCGGACAAGGACATTGTGGCGCGGG
TGGTGTCCATGCCGTGCGTGGAATGGTTCGAGTCCCAGCCCGACGACTACCGCGACAGTGTGCTGCCGCCGTCGGTGTCG
GCCCGGGTGGCCGTCGAGGCCGGGGTGGCGCAGAGCTGGCACAAGCTGGTCGGCGACACCGGGAAGATCATCTCGATCGA
GCACTACGGCGAATCCGCCGACTACAAAACGTTGTTCCGTGAATTCGGCTTCACTGCCGAAGCCGTCGCTGCCGCCGCGG
AAGAAGTCGTGGACAACTGA

Protein sequence :
MTTLEEISALTQPHLPDDWSELDSAAVDTIRVLAADAVQKVGNGHPGTAMSLAPLAYTLFQRVMRHDPSDTHWLGRDRFV
LSAGHSSLTLYLQLYLGGFGLELSDIESLRTWGSKTPGHPEFRHTKGVEITTGPLGQGLASAVGMAMASRYERGLFDPDA
AAGTSPFDHFIYVIASDGDIEEGVTSEASSLAAVQQLGNLIVFYDHNQISIEDDTNIALCEDTAARYEAYGWHVQRVEGG
ENVVAIEEAIAAAKAVTDRPSFIELRTIIGYPAPNAMNTGKAHGAALGEEEVAAVKKILGFDPDKTFQVRDKVIAHTRKL
VDRGREAHQKWQTDFDAWAQREPERKALLERLTAEKLPDGWDADLPHWEPGSDAIATRKASGAVLNAVAPKLPELWGGSA
DLAESNLTTINNADSFGPPSISTKEFTASWYGRVLHFGVREHAMGAILSGIVLHGPTRAYGGTFLQFSDYMRPAVRLASL
MDIDTIYVWTHDSIGLGEDGPTHQPIEHLAALRAIPKLSVVRPADANETAYAWRTILARGNGSGPVGLVLTRQGLPVLEG
TDADGVARGGYILGSDGEEAGQEPDVILIATGSEVQLAVEAQKLLADKDIVARVVSMPCVEWFESQPDDYRDSVLPPSVS
ARVAVEAGVAQSWHKLVGDTGKIISIEHYGESADYKTLFREFGFTAEAVAAAAEEVVDN

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tktA AAO17218.1 TktA Not tested tcd island Protein 3e-107 44
APECO1_2641 YP_859417.1 transketolase Not tested Not named Protein 6e-104 43