Gene Information

Name : MAV_2008 (MAV_2008)
Accession : YP_881227.1
Strain : Mycobacterium avium 104
Genome accession: NC_008595
Putative virulence/resistance : Virulence
Product : 2,3-dihydroxybenzoate-AMP ligase
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : 6.3.2.-
Position : 1991786 - 1993441 bp
Length : 1656 bp
Strand : -
Note : identified by match to protein family HMM PF00501

DNA sequence : 
ATGAGCCCCAACACCACGCCGCCGGCCGGAGTCCTCGACGGGTTCGTGCCGTTTCCCGCCGAGCGCGCCGCCGCCTACCG
GGCGGCCGGTTTGTGGACGGGGCGAGCCCTGGACACGATCCTGACCGACGCGGCCCGGCGGTGGCCCGACCGAACCGCCG
TCCTCGACGCCTCCGGCGGCACCGGTTTCAGCTACGCGGGCCTCGACGAGCAGGCTAACCGCGCCGCCGCGGGTTTGGCG
GACGCGGGTATCGCCCCCGGCGACCGGGTGCTGCTGCAGCTGCCGAACGGCTGCCAGTTCGCGGTGGCGCTGTTCGCGCT
GTTACGGGCGGGGGCGATCCCGGTGATGTGCCTGCCCGGCCACCGCGCCGCCGAGCTTGGGCATTTCGCCGCGCTCAGCC
AGGCCACCGCACTGCTGATCGCCGACACCGCAGCGGGTTTCGATTATCGAACGATGGCCGCGGGGCTCGTCGAGGAGCAT
GAAGCGCTCGCCCACGTGATCGTCGACGGCGACCCGGGGCCGTTTCTGTCCTGGGCGCAGCTGTGCGAGCGTGCGCCCGC
GGGGCGGCCGGCGACGCCGGTCGATCCGGGATCGCCTGCGCTGCTTCTGGTTTCCGGTGGCACCACCGGCACACCAAAGC
TCATCCCGCGCACCCACGACGATTACGTCTTCAACGCCAACGCCAGCGCCGAACTGTGCGGGCTCACCCGCGACGACGTC
TATCTGGCGGTGCTCTCGGCCGGCCACAATTTCCCGCTCGCCTGCCCCGGCCTGCTCGGCGCGATGACGGTGGGCGCGAC
CACGGTGTTCGGCACCGACCCCAGCCCCGAGGCGGCCTTTGCCACCATCGCGCGCCACGGCGTCACGGTGACCGCCCTGG
TCCCGGCCCTGGCCAAACTATGGGCGCACGCCTGCGAATGGGAGGACAATCCACCGAAGTCCTTGCGGCTCTTGCAAGTC
GGCGGCGCCAAGTTGGAGGCCGACGACGCCCGTGTGATCCGCAGCGCGTTGACGCCGGGCCTGCAGCAGGTGTTCGGGAT
GGCCGAGGGCCTGCTGAACTACACCCGGCTCGACGATCCACCGGAGATCACCGAGCACACCCAGGGACGGCCGTTGTCGA
CCGCCGACGAGGTGCGGGTGGTCGACGCGGCGGGCAATCCCGTTGCCCCGGGGCAGGAAGGCGAACTGCTGGTCCGCGGA
CCGTACACGTTCAACGGTTATTTCCGGGCCGAACGCGACAATCAACGCTGCTTCGACGCGCAGGGCTTTTTCCGCAGCGG
CGATTTGGTCCGGGTCCGCGATGATGGCTACCTGGTGGTGACCGGACGGGTCAAGGACGTGATCTGCCGTGGCGGCGAGA
CGATTTCCGCGGCCGACCTCGAGGAGCAGATGCTGAGCCACCCGGCGATCTTCTCGGCCGCCGCAGTACCCCTCCCCGAC
CCCTACCTCGGCGAAAAGATCTGTGCCGCTGTCGTTTTCGAGGGCCCGGCGCTGTCACTCGCGGAGTTGAACGGCTACCT
GGACGAGCGCGGTGTGGCCGCGCACGCCCGTCCCGACGTCCTGGCCGCGATGCCGTCATTGCCCACCACGCCGATCGGCA
AGATCGACAAAAAGGCGATCGCGAACCAGGTATCGGCGCGGAATCGGCGTCCCTGA

Protein sequence : 
MSPNTTPPAGVLDGFVPFPAERAAAYRAAGLWTGRALDTILTDAARRWPDRTAVLDASGGTGFSYAGLDEQANRAAAGLA
DAGIAPGDRVLLQLPNGCQFAVALFALLRAGAIPVMCLPGHRAAELGHFAALSQATALLIADTAAGFDYRTMAAGLVEEH
EALAHVIVDGDPGPFLSWAQLCERAPAGRPATPVDPGSPALLLVSGGTTGTPKLIPRTHDDYVFNANASAELCGLTRDDV
YLAVLSAGHNFPLACPGLLGAMTVGATTVFGTDPSPEAAFATIARHGVTVTALVPALAKLWAHACEWEDNPPKSLRLLQV
GGAKLEADDARVIRSALTPGLQQVFGMAEGLLNYTRLDDPPEITEHTQGRPLSTADEVRVVDAAGNPVAPGQEGELLVRG
PYTFNGYFRAERDNQRCFDAQGFFRSGDLVRVRDDGYLVVTGRVKDVICRGGETISAADLEEQMLSHPAIFSAAAVPLPD
PYLGEKICAAVVFEGPALSLAELNGYLDERGVAAHARPDVLAAMPSLPTTPIGKIDKKAIANQVSARNRRP

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ybtE CAA21394.1 - Virulence HPI Protein 1e-93 44
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 4e-94 44
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 9e-94 44
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 3e-94 44
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 1e-93 44
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-93 44
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 1e-93 44
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-93 44
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-93 44

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
MAV_2008 YP_881227.1 2,3-dihydroxybenzoate-AMP ligase VFG1817 Protein 0.0 79
MAV_2008 YP_881227.1 2,3-dihydroxybenzoate-AMP ligase VFG0168 Protein 1e-90 46
MAV_2008 YP_881227.1 2,3-dihydroxybenzoate-AMP ligase VFG0932 Protein 4e-81 42