Gene Information

Name : guaA (NT01CX_0459)
Accession : YP_878930.1
Strain : Clostridium novyi NT
Genome accession: NC_008593
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : -
Position : 2139825 - 2141363 bp
Length : 1539 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGGCTATAGAACGTGAATTAGTTTTAGTAGTGGACTTTGGTGGACAATATAACCAGCTTATCGCAAGAAGAGTTAGAGA
ACACAATGTATATTGCGAAATAATACCATACACTACTTCTGTTGAAGATATAAAAAAGAAAAATCCAAAAGCTATAATAT
TTACTGGAGGACCTAACAGTGTTTATGGTGAAGGAACTCCAAGAGTAGAAAAAGAAATATTTGAACTTGGAGTACCTGTA
CTTGGAATATGCTATGGACATCAATTAACAGCTTATACATTAGGCGGAAAAGTTGAAAGTCCAGATATAAGAGAGTACGG
AAAAACAGAAGTTAAGATTGATAACAAATCACCTTTATTTGATGGAATAAAAGAAGCAGATCAATCATGGATGAGCCATA
CTGACTATGTATCAGAAATTCCAGAAGGATTTAAAATAATAGCAACAACAGATCAATGTCCTGTAGCTGCAATGGCAAAC
GAAGAAAAGAAAATATATGGGGTTCAATTCCATCCAGAAGTTGAACATACATTATTCGGACAAAAAATGCTTGGAAACTT
CTTATTTAAAGTAGCTGGTCTTAAAGCAGATTGGTCAATGGCATCTTTCGCTGAAGAAAAGATAAAAGCTATAAAAGAAC
TTGTAGGAGACAAAAAAGTGCTTTGTGCATTATCAGGTGGAGTTGATTCATCAGTTGCGGCAGTACTTGTTCATAAAGCA
ATTGGTAAACAATTAACTTGTGTATTTGTTGATCACGGTTTACTTAGAAAAGATGAAGGAGATCAAGTTGAAGCTATATT
CAAGAAGCAATTTGATATGAACCTTATAAGAGTAAATGCAGGAGAAAGATTCCTTGGAAAATTAAAAGGAGTAAGCGATC
CTGAAACAAAGAGAAAGATAATCGGAGAAGAATTCATAAGAGTGTTTGAAGAAGAAGCTGGAAAACTTGGACAAATAGAC
TTCCTAGTTCAAGGAACTATATACCCAGACGTAGTTGAAAGTGGAACTAACACATCAGCTACAATAAAGAGTCACCACAA
TGTTGGAGGACTTCCTGAAGACATGCAATTCTCTTTAATAGAACCATTAAGAGAACTATTCAAAGATGAAGTTAGAGCAG
TTGGAGAAGAACTTGGAATCCCTCACAAATTAGTGTGGAGACAACCATTCCCAGGACCAGGTCTTGCAATAAGAGTTCTT
GGAGAAATAACAGAAGAAAAATTAGAAATAACAAGAGAAGCAGATGCAATATTCAGAGAAGAAATTGCACTTGCAGGACT
TGAAGAAAAGATATGGCAATACTTTGCATGTCTTCCTAACATTCAATCAGTTGGTGTTATGGGAGATGAAAGAACATACT
GCCACACAATAGCATTAAGAGCGGTAACATCAAGTGATGCTATGACTTCAGATTGGGCAAGAATCCCATACGAAGTATTA
GACAAAGTAAGTCGTCGTATAGTTAATGAAGTTAAGGGAGTAAACAGAATTGTTTATGATGTAACTTCAAAACCACCAGC
AACTATTGAGTGGGAATAA

Protein sequence :
MAIERELVLVVDFGGQYNQLIARRVREHNVYCEIIPYTTSVEDIKKKNPKAIIFTGGPNSVYGEGTPRVEKEIFELGVPV
LGICYGHQLTAYTLGGKVESPDIREYGKTEVKIDNKSPLFDGIKEADQSWMSHTDYVSEIPEGFKIIATTDQCPVAAMAN
EEKKIYGVQFHPEVEHTLFGQKMLGNFLFKVAGLKADWSMASFAEEKIKAIKELVGDKKVLCALSGGVDSSVAAVLVHKA
IGKQLTCVFVDHGLLRKDEGDQVEAIFKKQFDMNLIRVNAGERFLGKLKGVSDPETKRKIIGEEFIRVFEEEAGKLGQID
FLVQGTIYPDVVESGTNTSATIKSHHNVGGLPEDMQFSLIEPLRELFKDEVRAVGEELGIPHKLVWRQPFPGPGLAIRVL
GEITEEKLEITREADAIFREEIALAGLEEKIWQYFACLPNIQSVGVMGDERTYCHTIALRAVTSSDAMTSDWARIPYEVL
DKVSRRIVNEVKGVNRIVYDVTSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 5e-163 65
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 3e-163 65
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 3e-163 65
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-143 56