Gene Information

Name : megL (NT01CX_0149)
Accession : YP_878658.1
Strain : Clostridium novyi NT
Genome accession: NC_008593
Putative virulence/resistance : Resistance
Product : methionine gamma-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : -
Position : 1801756 - 1802964 bp
Length : 1209 bp
Strand : -
Note : catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine

DNA sequence :
ATGAGTAATGAACATAACTTAAGCAATATGGGTTTTGGAACAAAGACTGTACATGGAGGACATATTAAAGATACTCAATT
TGGATCACTTGCAACACCAATATTCCAAACATCAACATTTATATTTGATTCAGCAGAACAAGGTGGAAATAGATTTGCGG
GAAAAGAAGATGGATATATTTACTCAAGAATAGCAAATCCAACTGTTGCAGAAATAGAAAGAAAAATTGCTTTATTAGAA
GGTGGAGAAGCTGCAATAGGAACAGCATCAGGAATGGGTGCTATATCATCAGCTTTATGGACTGCATTAAAAGCAGGAGA
CCATGTAGTTGCATCTGATACATTATATGGTTGTACATTCGCATTATTAAATCATGGATTAACTAAAATGGGTGTAGAAG
TTACATTTGTAGATCCAACTAATTTAGAAGAAGTTAAAAATGCAATGAAGGAAAATACAAGAGTTGTTTATCTTGAAACT
CCAGCAAATCCAACATTGAAAGTTACAGACATAGAAGGAATAGCTAAAATAGCACATGAAGTTAAAGATTGTTTAGTATT
TGTTGATAATACATTTAATACTCCATATATTCAAAGACCATTAGAACTTGGTGCAGATGTAGTAGTACATTCAGCAACTA
AATATATAAATGGACACGGGGATGTTGTTGCTGGATTTGTAATAGGAAATGCAGACTTTATAGGTGCAGTTAGAGGACAG
GGATTAAAAGATATGACAGGTGCAGTTATGAGTCCATTAAGTGCTTTTTTAATTATAAGAGGAATGAAAACATTAGAAAT
TAGAATGGAAAGACATTGTGCTAATGCAATGAAAGTAGCACAATTCTTAGAAGCTCATCCAGCAGTAGAAAAAGTATATT
ATCCAGGACTTGAAAGCTTTGAATATCACGATTTAGCTAAAAAGCAAATGGATTTACCAGGAGCTATGATTTCATTTGAA
ATAAAAGGTGGAGTTGAAGAAGGAAGAACTATTATGAATAACGTAAAACTTGCAAGTCTTGCAGTAAGTCTTGGAGATAC
AGAAACATTAATTCAACATCCTGCATCAATGACTCACTCACCATATACTAAAGAAGAAAGAGCAGAAGCTGGAATAAGTG
ATAGCTTAGTTAGATTATCAGTTGGTCTTGAAACTGTTGATGATATAATTGCCGACTTAAAACAAGCTTTAGATTTAATA
GTAAAATAA

Protein sequence :
MSNEHNLSNMGFGTKTVHGGHIKDTQFGSLATPIFQTSTFIFDSAEQGGNRFAGKEDGYIYSRIANPTVAEIERKIALLE
GGEAAIGTASGMGAISSALWTALKAGDHVVASDTLYGCTFALLNHGLTKMGVEVTFVDPTNLEEVKNAMKENTRVVYLET
PANPTLKVTDIEGIAKIAHEVKDCLVFVDNTFNTPYIQRPLELGADVVVHSATKYINGHGDVVAGFVIGNADFIGAVRGQ
GLKDMTGAVMSPLSAFLIIRGMKTLEIRMERHCANAMKVAQFLEAHPAVEKVYYPGLESFEYHDLAKKQMDLPGAMISFE
IKGGVEEGRTIMNNVKLASLAVSLGDTETLIQHPASMTHSPYTKEERAEAGISDSLVRLSVGLETVDDIIADLKQALDLI
VK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 6e-66 43
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 5e-67 43
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 2e-55 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
megL YP_878658.1 methionine gamma-lyase BAC0207 Protein 2e-107 56