|
Name : ureC (Mmc1_1027) Accession : YP_864951.1 Strain : Magnetococcus marinus MC-1 Genome accession: NC_008576 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : 3.5.1.5 Position : 1257310 - 1259019 bp Length : 1710 bp Strand : + Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGGCATATACCCTAGATCGCGGCAGCTATGCGGCCATGTTTGGACCGACGGTTGGCGACCGTGTGCGGTTGGCCGACAC CGAGCTGATTATTGAGGTGGAGCAGGATTACACCACCTATGGTGAAGAGGTTAAATTTGGCGGCGGCAAGGTGATTCGTG ATGGCATGGGGCAGTCCCAGCACAGCCGTCAGGAGGGGGCGGTGGATACGGTGATCACCAACGCCCTGATTGTGGATCAC TGGGGGATTGTCAAAGCGGATGTGGGTATTAAGGATGGTCGTATCTGCGCCATTGGCAAAGCGGGCAACCCCGATGTGCA GCCCAATGTGGATATTATAATCGGCCCCGGTACCGAGGCCATTGCCGGGGAGGGGCGTATTCTCACCGCTGGGGGCATTG ACGCCCATATTCACTGGATCTGCCCACAACAGATTGAGGATGCTTTGCATAGCGGCATTACCACCATGCTGGGGGGTGGC ACGGGTCCGGCTGAGGGGACCAATGCCACCACCTGCACGCCGGGGCCGTGGCATATTGCGCGTATGCTCCAGGCGGCAGA GGGGTTGCCCATGAATATGGGCTTTTTTGGTAAGGGCAATGCCTCGCGCCCCCAGGGGTTGGAGGAGCAGTTACGGGCCG GGGCGTGTGGTCTGAAGTTGCATGAGGATTGGGGCACCACCCCCAGCGCCATTGATGTCTGTTTGAGTGTGGCGGAGAAG TGGGATGTGCAGGTGGCCATCCATACCGATACCTTGAACGAGTCGGGCTTTGTGGAGAACACCACGGCAGCCTTTAAGGG GCGCACCATCCACGCTTTTCATACCGAAGGGGCGGGGGGTGGCCATGCGCCGGATATTATTAAATTGTGTGGCGAGGCCA ATGTGTTGCCCAGTTCCACCAATCCGACCCGTCCCTTTACCCGCAACACCCTTGATGAACACCTGGATATGCTTATGGTA TGTCACCATTTGGATAGCCGGATTCCCGAAGATGTGGCCTTTGCCGAGAGCCGTATTCGCCGCGAGACCATAGCGGCGGA GGATATTTTGCACGATCTGGGGGCTTTTTCCATGATCGCCTCGGACAGTCAGGCCATGGGGCGGGTGGGGGAGGTGATTA TCCGCACTTGGCAGACCGCCGATAAGATGAAACGCCAGCGGGGCGCCTTGCCGGAAGAGCGGGGGCAAAACGACAATCAG CGGGTTAAGCGCTACATTGCCAAATATACCATCAACCCCGCCATTACCCACGGTATTGCCCACTATGTGGGCTCGGTTGC GGTGGGTAAGTTGGCCGATTTGGTGTTGTGGAAACCGATGTTTTTTGGGGTTAAGCCTGATTTGGTCTTAAAGTGCGGCA CCATTGCCTCGGCGGCGATGGGGGACCCCAACGCCTCCATCCCCACCCCGCAACCGGTACACTATCGCCCCATGTTTGGG GCCTTTGGTGGGGCCTTGACCCACAGCGCGGTCAACTTTGTCAGTCAGGCCGGGTTGGATGGGGAGATTGCCCAGCAGTT TGGGCTGCGTAAAACCCTGCTGCCGGTGGTGGGGTGTCGCACCATCGGCAAAGCCGATATGGTGCACAACAGCGCCACCC CCCACATGGAGGTGGATCCAGAAACCTATGAGGTGCGGGCCGATGGGCGGTTGTTAACCTGTGAACCGGCCACGGTATTG CCCTTGGCGCAACGCTATTTCCTGTTTTAA Protein sequence : MAYTLDRGSYAAMFGPTVGDRVRLADTELIIEVEQDYTTYGEEVKFGGGKVIRDGMGQSQHSRQEGAVDTVITNALIVDH WGIVKADVGIKDGRICAIGKAGNPDVQPNVDIIIGPGTEAIAGEGRILTAGGIDAHIHWICPQQIEDALHSGITTMLGGG TGPAEGTNATTCTPGPWHIARMLQAAEGLPMNMGFFGKGNASRPQGLEEQLRAGACGLKLHEDWGTTPSAIDVCLSVAEK WDVQVAIHTDTLNESGFVENTTAAFKGRTIHAFHTEGAGGGHAPDIIKLCGEANVLPSSTNPTRPFTRNTLDEHLDMLMV CHHLDSRIPEDVAFAESRIRRETIAAEDILHDLGAFSMIASDSQAMGRVGEVIIRTWQTADKMKRQRGALPEERGQNDNQ RVKRYIAKYTINPAITHGIAHYVGSVAVGKLADLVLWKPMFFGVKPDLVLKCGTIASAAMGDPNASIPTPQPVHYRPMFG AFGGALTHSAVNFVSQAGLDGEIAQQFGLRKTLLPVVGCRTIGKADMVHNSATPHMEVDPETYEVRADGRLLTCEPATVL PLAQRYFLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 0.0 | 71 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 0.0 | 71 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 6e-168 | 61 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 2e-169 | 61 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 2e-169 | 61 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 2e-169 | 61 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_864951.1 | urease subunit alpha | VFG0270 | Protein | 3e-169 | 64 |
